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- W2956120111 endingPage "18587" @default.
- W2956120111 startingPage "18572" @default.
- W2956120111 abstract "Helicobacter pylori and humans have one of the most complex relationships in nature. How a bacterium manages to live in one of the harshest and hostile environments is a topic of unraveling mysteries. H. pylori is a prevalent species and it colonizes the human gut of more than 50% of the world population. It infects the epithelial region of antrum and persists there for a long period. Over the time of evolution, H. pylori has developed complex strategies to extend the degree of inflammation in gastric mucosa. H. pylori needs specific adaptations for initial colonization into the host environment like helical shape, flagellar movement, chemotaxis, and the production of urease enzyme that neutralizes acidic environment of the stomach. There are several factors from the bacterium as well as from the host that participate in these complex interactions. On the other hand, to establish the persistent infection, H. pylori escapes the immune system by mimicking the host antigens. This pathogen has the ability to dodge the immune system and then persist there in the form of host cell, which leads to immune tolerance. H. pylori has an ability to manipulate its own pathogen-associated molecular patterns, which leads to an inhibition in the binding with specific pattern recognition receptors of the host to avoid immune cell detection. Also, it manipulates the host metabolic homeostasis in the gastric epithelium. Besides, it has several genes, which may get involved in the acquisition of nutrition from the host to survive longer in the host. Due to the persistence of H. pylori, it causes chronic inflammation and raises the chances of gastric cancer. This review highlights the important elements, which are certainly responsible for the persistence of H. pylori in the human host." @default.
- W2956120111 created "2019-07-12" @default.
- W2956120111 creator A5022551110 @default.
- W2956120111 creator A5036657100 @default.
- W2956120111 creator A5039174452 @default.
- W2956120111 creator A5048132282 @default.
- W2956120111 date "2019-06-25" @default.
- W2956120111 modified "2023-10-18" @default.
- W2956120111 title "Unraveling the factors and mechanism involved in persistence: Host‐pathogen interactions in<i>Helicobacter pylori</i>" @default.
- W2956120111 cites W1683558607 @default.
- W2956120111 cites W1713173235 @default.
- W2956120111 cites W1783081409 @default.
- W2956120111 cites W1796772814 @default.
- W2956120111 cites W188036464 @default.
- W2956120111 cites W1916325998 @default.
- W2956120111 cites W1922060841 @default.
- W2956120111 cites W1960908597 @default.
- W2956120111 cites W1965341361 @default.
- W2956120111 cites W1966944415 @default.
- W2956120111 cites W1967269697 @default.
- W2956120111 cites W1967918248 @default.
- W2956120111 cites W1969975290 @default.
- W2956120111 cites W1975061369 @default.
- W2956120111 cites W1975213539 @default.
- W2956120111 cites W1978063560 @default.
- W2956120111 cites W1979390293 @default.
- W2956120111 cites W1980447876 @default.
- W2956120111 cites W1980915712 @default.
- W2956120111 cites W1983517028 @default.
- W2956120111 cites W1985052443 @default.
- W2956120111 cites W1985403135 @default.
- W2956120111 cites W1986296146 @default.
- W2956120111 cites W1991444764 @default.
- W2956120111 cites W1992022935 @default.
- W2956120111 cites W1992316276 @default.
- W2956120111 cites W1995028256 @default.
- W2956120111 cites W1999518808 @default.
- W2956120111 cites W2002581229 @default.
- W2956120111 cites W2009107334 @default.
- W2956120111 cites W2012750529 @default.
- W2956120111 cites W2014499322 @default.
- W2956120111 cites W2015449706 @default.
- W2956120111 cites W2023164612 @default.
- W2956120111 cites W2025940700 @default.
- W2956120111 cites W2026584719 @default.
- W2956120111 cites W2027619928 @default.
- W2956120111 cites W2032739064 @default.
- W2956120111 cites W2033109379 @default.
- W2956120111 cites W2033697781 @default.
- W2956120111 cites W2037026830 @default.
- W2956120111 cites W2037198693 @default.
- W2956120111 cites W2038461328 @default.
- W2956120111 cites W2040564981 @default.
- W2956120111 cites W2042389184 @default.
- W2956120111 cites W2044025776 @default.
- W2956120111 cites W2044227662 @default.
- W2956120111 cites W2045475619 @default.
- W2956120111 cites W2046617066 @default.
- W2956120111 cites W2047043794 @default.
- W2956120111 cites W2047989094 @default.
- W2956120111 cites W2048020744 @default.
- W2956120111 cites W2049732161 @default.
- W2956120111 cites W2050126947 @default.
- W2956120111 cites W2050449334 @default.
- W2956120111 cites W2051508921 @default.
- W2956120111 cites W2055630289 @default.
- W2956120111 cites W2056934197 @default.
- W2956120111 cites W2066293700 @default.
- W2956120111 cites W2073924276 @default.
- W2956120111 cites W2075476726 @default.
- W2956120111 cites W2076673615 @default.
- W2956120111 cites W2079716793 @default.
- W2956120111 cites W2084000863 @default.
- W2956120111 cites W2090417696 @default.
- W2956120111 cites W2092946137 @default.
- W2956120111 cites W2095320380 @default.
- W2956120111 cites W2095495335 @default.
- W2956120111 cites W2097716909 @default.
- W2956120111 cites W2097783688 @default.
- W2956120111 cites W2098027198 @default.
- W2956120111 cites W2101279291 @default.
- W2956120111 cites W2101996554 @default.
- W2956120111 cites W2102586400 @default.
- W2956120111 cites W2102635879 @default.
- W2956120111 cites W2105424869 @default.
- W2956120111 cites W2109566059 @default.
- W2956120111 cites W2111839842 @default.
- W2956120111 cites W2111909489 @default.
- W2956120111 cites W2114361018 @default.
- W2956120111 cites W2116056203 @default.
- W2956120111 cites W2116142734 @default.
- W2956120111 cites W2117237221 @default.
- W2956120111 cites W2117655685 @default.
- W2956120111 cites W2118065377 @default.
- W2956120111 cites W2119826799 @default.
- W2956120111 cites W2119892071 @default.
- W2956120111 cites W2120183465 @default.
- W2956120111 cites W2120889005 @default.