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• W2956127535 endingPage "577" @default.
• W2956127535 startingPage "577" @default.
• W2956127535 abstract "The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (ORF2) for RNA-dependent RNA polymerase (RdRp). How the downstream open reading frames (ORFs) are expressed is genus-specific. All victoriviruses characterized thus far appear to use the stop/restart translation mechanism, allowing for the expression of two separate protein products from bicitronic genome-sized viral mRNA, while the totiviruses use a -1 ribosomal frame-shifting that leads to a fusion product of CP and RdRp. We report the biological and molecular characterization of a novel victorivirus termed Alternaria alternata victorivirus 1 (AalVV1) isolated from Alternaria alternata in Pakistan. The phylogenetic and molecular analyses showed AalVV1 to be distinct from previously reported victoriviruses. AalVV1 appears to have a sequence signature required for the -1 frame-shifting at the ORF1/2 junction region, rather than a stop/restart key mediator. By contrast, SDS-polyacrylamide gel electrophoresis and peptide mass fingerprinting analyses of purified virion preparations suggested the expression of two protein products, not a CP-RdRp fusion product. How these proteins are expressed is discussed in this study. Possible effects of infection by this virus were tested in two fungal species: A. alternata and RNA silencing proficient and deficient strains of Cryphonectria parasitica, a model filamentous fungus. AalVV1 showed symptomless infection in all of these fungal strains, even in the RNA silencing deficient C. parasitica strain." @default.
• W2956127535 created "2019-07-12" @default.
• W2956127535 creator A5036310631 @default.
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• W2956127535 date "2019-06-25" @default.
• W2956127535 modified "2023-10-13" @default.
• W2956127535 title "Novel Victorivirus from a Pakistani Isolate of Alternaria alternata Lacking a Typical Translational Stop/Restart Sequence Signature" @default.
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• W2956127535 doi "https://doi.org/10.3390/v11060577" @default.
• W2956127535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6631646" @default.
• W2956127535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31242660" @default.
• W2956127535 hasPublicationYear "2019" @default.
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