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• W2956132594 endingPage "316" @default.
• W2956132594 startingPage "305" @default.
• W2956132594 abstract "Physical and psychosocial maltreatment experienced before the age of 18, termed early life adversity (ELA), affects an estimated 39% of the world's population, and has long-term detrimental health and psychological outcomes. While adult phenotypes vary following ELA, inflammation and altered stress responsivity are pervasive. Cytokines, most notably tumor necrosis factor (TNF), are elevated in adults with a history of ELA. While soluble TNF (solTNF) drives chronic inflammatory disease, transmembrane TNF facilitates innate immunity. Here, we test whether solTNF mediates the behavioral and molecular outcomes of adolescent psychological stress by administering a brain permeable, selective inhibitor of solTNF, XPro1595. Male and female C57BL/6 mice were exposed to an aggressive rat through a perforated translucent ball ('predatory stress') or transported to an empty room for 30 min for 30 days starting on postnatal day 34. Mice were given XPro1595 or vehicle treatment across the last 15 days. Social interaction, sucrose preference, and plasma inflammation were measured at 2 and 4 weeks, and open field behavior, adiposity, and neuroinflammation were measured at 4 weeks. Chronic adolescent stress resulted in increased peripheral inflammation and dysregulated neuroinflammation in adulthood in a sex-specific manner. Abnormal social and open field behavior, fat pad weight, and fecal boli deposition were noted after 30 days; solTNF antagonism ameliorated the effects of stress. Together, these data support our hypothesis, and suggest that targeting solTNF with XPro1595 may improve quality of life for individuals with a history of adolescent stress." @default.
• W2956132594 created "2019-07-12" @default.
• W2956132594 creator A5001117325 @default.
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• W2956132594 creator A5016915272 @default.
• W2956132594 creator A5023732082 @default.
• W2956132594 creator A5025810628 @default.
• W2956132594 creator A5030638283 @default.
• W2956132594 creator A5059363586 @default.
• W2956132594 creator A5060299240 @default.
• W2956132594 creator A5072436287 @default.
• W2956132594 creator A5080377837 @default.
• W2956132594 date "2019-10-01" @default.
• W2956132594 modified "2023-10-14" @default.
• W2956132594 title "Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595" @default.
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