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- W2956138313 endingPage "119063" @default.
- W2956138313 startingPage "119063" @default.
- W2956138313 abstract "Genomic imprinting is an epigenetic process result in silencing of one of the two alleles (maternal or paternal) based on the parent of origin. Dysregulation of imprinted genes results in detectable developmental and differential abnormalities. Epigenetics erasure is required for resetting the cell identity to a ground state during the production of induced pluripotent stem (iPS) cells from somatic cells. There are some contradictory reports regarding the status of the imprinting marks in the genome of iPS cells. Additionally, many studies highlighted the existence of subtle differences in the imprinting loci between different types of iPS cells and embryonic stem (ES) cells. These observations could ultimately undermine the use of patient-derived iPS cells for regenerative medicine." @default.
- W2956138313 created "2019-07-12" @default.
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- W2956138313 date "2019-12-01" @default.
- W2956138313 modified "2023-10-16" @default.
- W2956138313 title "Genome imprinting in stem cells: A mini-review" @default.
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- W2956138313 doi "https://doi.org/10.1016/j.gep.2019.119063" @default.
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