FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956140411> ?p ?o ?g. }

• W2956140411 endingPage "10527" @default.
• W2956140411 startingPage "10515" @default.
• W2956140411 abstract "Histone Lys-specific demethylases (KDMs) play a key role in many biological processes through epigenetic mechanisms. However, the role of KDMs in inflammatory responses to oral bacterial infection is poorly understood. Here, we show a novel regulatory role of KDM3C in inflammatory responses to oral bacterial infection. KDM3C expression is transiently suppressed in human and mouse macrophages exposed to LPS from Porphyromonas gingivalis (Pg LPS). Loss of KDM3C in both human and mouse macrophages led to notable induction of proinflammatory cytokines in response to Pg LPS stimulation. Also, KDM3C depletion led to strong induction of p65 phosphorylation and accelerated nuclear translocation in cells exposed to Pg LPS. Kdm3C knockout (KO) in mice led to increased alveolar bone destruction upon induction of experimental periodontitis or pulp exposure compared with those of the wild-type (WT) littermates. The Kdm3C KO mice also revealed an increased number of osteoclasts juxtaposed to the bony lesions. We also confirmed enhanced osteoclastogenesis by bone marrow–derived macrophages isolated from the Kdm3C KO compared with the WT controls. These findings suggest an anti-inflammatory function of KDM3C in regulating the inflammatory responses against oral bacterial infection through suppression of NF-κB signaling and osteoclastogenesis.—Lee, J. Y., Mehrazarin, S., Alshaikh, A., Kim, S., Chen, W., Lux, R., Gwack, Y., Kim, R. H., Kang, M. K. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 33, 10515–10527 (2019). www.fasebj.org" @default.
• W2956140411 created "2019-07-12" @default.
• W2956140411 creator A5004255490 @default.
• W2956140411 creator A5010908506 @default.
• W2956140411 creator A5017541508 @default.
• W2956140411 creator A5021257318 @default.
• W2956140411 creator A5022746055 @default.
• W2956140411 creator A5048125311 @default.
• W2956140411 creator A5054026589 @default.
• W2956140411 creator A5066520771 @default.
• W2956140411 creator A5091561042 @default.
• W2956140411 date "2019-06-28" @default.
• W2956140411 modified "2023-10-14" @default.
• W2956140411 title "Histone Lys demethylase KDM3C demonstrates anti‐inflammatory effects by suppressing NF‐κB signaling and osteoclastogenesis" @default.
• W2956140411 cites W1509466986 @default.
• W2956140411 cites W1549679997 @default.
• W2956140411 cites W1583504016 @default.
• W2956140411 cites W1603793127 @default.
• W2956140411 cites W1753749227 @default.
• W2956140411 cites W1943143611 @default.
• W2956140411 cites W1973455669 @default.
• W2956140411 cites W1975587041 @default.
• W2956140411 cites W1991938395 @default.
• W2956140411 cites W1995419221 @default.
• W2956140411 cites W1997072139 @default.
• W2956140411 cites W1997948377 @default.
• W2956140411 cites W2000200899 @default.
• W2956140411 cites W2003581234 @default.
• W2956140411 cites W2004608668 @default.
• W2956140411 cites W2015593957 @default.
• W2956140411 cites W2026426908 @default.
• W2956140411 cites W2030574509 @default.
• W2956140411 cites W2033684266 @default.
• W2956140411 cites W2037582642 @default.
• W2956140411 cites W2038191439 @default.
• W2956140411 cites W2043638973 @default.
• W2956140411 cites W2049293744 @default.
• W2956140411 cites W2059997982 @default.
• W2956140411 cites W2062835892 @default.
• W2956140411 cites W2064297857 @default.
• W2956140411 cites W2066749771 @default.
• W2956140411 cites W2079637100 @default.
• W2956140411 cites W2084398450 @default.
• W2956140411 cites W2084986398 @default.
• W2956140411 cites W2096851217 @default.
• W2956140411 cites W2111846773 @default.
• W2956140411 cites W2121652706 @default.
• W2956140411 cites W2129242841 @default.
• W2956140411 cites W2129319296 @default.
• W2956140411 cites W2135488281 @default.
• W2956140411 cites W2144929276 @default.
• W2956140411 cites W2155149522 @default.
• W2956140411 cites W2157107389 @default.
• W2956140411 cites W2163771097 @default.
• W2956140411 cites W2166313509 @default.
• W2956140411 cites W2167357230 @default.
• W2956140411 cites W2169568373 @default.
• W2956140411 cites W2399374800 @default.
• W2956140411 cites W2523691404 @default.
• W2956140411 cites W2550812386 @default.
• W2956140411 cites W2589052931 @default.
• W2956140411 cites W2616123180 @default.
• W2956140411 cites W2739174192 @default.
• W2956140411 cites W2748623022 @default.
• W2956140411 cites W2781979842 @default.
• W2956140411 doi "https://doi.org/10.1096/fj.201900154rr" @default.
• W2956140411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6704463" @default.
• W2956140411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31251083" @default.
• W2956140411 hasPublicationYear "2019" @default.
• W2956140411 type Work @default.
• W2956140411 sameAs 2956140411 @default.
• W2956140411 citedByCount "16" @default.
• W2956140411 countsByYear W29561404112020 @default.
• W2956140411 countsByYear W29561404112021 @default.
• W2956140411 countsByYear W29561404112022 @default.
• W2956140411 countsByYear W29561404112023 @default.
• W2956140411 crossrefType "journal-article" @default.
• W2956140411 hasAuthorship W2956140411A5004255490 @default.
• W2956140411 hasAuthorship W2956140411A5010908506 @default.
• W2956140411 hasAuthorship W2956140411A5017541508 @default.
• W2956140411 hasAuthorship W2956140411A5021257318 @default.
• W2956140411 hasAuthorship W2956140411A5022746055 @default.
• W2956140411 hasAuthorship W2956140411A5048125311 @default.
• W2956140411 hasAuthorship W2956140411A5054026589 @default.
• W2956140411 hasAuthorship W2956140411A5066520771 @default.
• W2956140411 hasAuthorship W2956140411A5091561042 @default.
• W2956140411 hasBestOaLocation W29561404111 @default.
• W2956140411 hasConcept C104317684 @default.
• W2956140411 hasConcept C11960822 @default.
• W2956140411 hasConcept C126322002 @default.
• W2956140411 hasConcept C164027704 @default.
• W2956140411 hasConcept C170493617 @default.
• W2956140411 hasConcept C182704531 @default.
• W2956140411 hasConcept C185592680 @default.
• W2956140411 hasConcept C203014093 @default.
• W2956140411 hasConcept C2776914184 @default.
• W2956140411 hasConcept C2777730290 @default.
• W2956140411 hasConcept C2780183776 @default.

• next