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- W2956147906 abstract "The Abelmoschus Manihot (AM) is one of the Traditional Chinese Medicine herbs be used in the treatment of some kidney diseases. The total flavonoids of AM (TFA) are the main extracts. Up to date, the detailed mechanisms by which AM improves some kinds of renal disease are still not fully understood. In the current study, we aimed to evaluate the role and mechanisms of TFA in Adriamycin-induced renal tubular injury both in vitro and in vivo. To study the toxicity of lipid, we use different concentrations of PA to induce HK2 cell injury. We use CCK8 cell viability detection, Tunel staining, FITC/PI flow cytometry and western blot to analysis of the protective effects of Rhein in PA-triggered HK2 impairment. We observed the PA-induced HK2 cells morphological changes and loss of cell viability after 24h. The Rhein obviously reduced the cell damage elicited by PA, improved morphological changes, attenuated the loss of cell viability. Through the Western blot analysis, we found that Rhein inhibited PA-induced autophagy. In addition, through the fluorescence optical microscopy observation, we confirmed that PA activated autophagy, and autophagy inhibitor did not affect autophagy flow. Western blot results suggested PA increased autophagy upstream by upregulating AMPK-mTOR signaling pathways. And the Rhein prohibited AMPK to regulate mTOR - ULK1 pathway. Rhein attenuated the PA-induced renal tubular cell injury by regulating AMPK-mTOR-Autophagy pathway" @default.
- W2956147906 created "2019-07-12" @default.
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- W2956147906 date "2019-07-01" @default.
- W2956147906 modified "2023-10-16" @default.
- W2956147906 title "MON-209 Rhein Attenuated Palmitic Acid-induced Renal Tubular Cell Injury by Regulating AMPK-mTOR-Autophagy Pathway" @default.
- W2956147906 doi "https://doi.org/10.1016/j.ekir.2019.05.1007" @default.
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