Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956149178> ?p ?o ?g. }
- W2956149178 endingPage "3340" @default.
- W2956149178 startingPage "3329" @default.
- W2956149178 abstract "Open wounds (e.g., burns and trauma) are always challenged by various opportunistic bacteria. There is an urgent need for developing novel wound dressing that is able to prevent bacterial infection and promote the healing simultaneously. Herein, we developed a new type of antimicrobial hydrogels for the open wound healing through imitating a facile mussel-inspired catechol/polyamine chemistry. This hydrogel was prepared using catechol (CT) and ε-poly-l-lysine (EPL) by oxidative cross-linking directly in the open air at room temperature. This nonleaching CT/EPL hydrogel not only exhibited excellent contact-active antimicrobial activities against Gram-negative bacteria Escherichia coli (E. coli) and Gram-positive superbug methicillin-resistant Staphylococcus aureus (MRSA) but also inhibited the biofilm formation in vitro. Moreover, the animal burn wound model study clearly validated the in vivo anti-infective property of CT/EPL hydrogel against MRSA infection. More importantly, the CT/EPL hydrogel possessed low cytotoxicity and enhanced cell migration in vitro. A full-thickness cutaneous wound model study revealed that CT/EPL hydrogel upregulated the expression of vascular endothelial growth factor (VEGF) and reduced the production of the pro-inflammatory cytokines, thus promoted the wound healing. These findings suggested that the CT/EPL hydrogel have great potential as a wound dressing for preventing bacterial infection and accelerating healing of open wounds." @default.
- W2956149178 created "2019-07-12" @default.
- W2956149178 creator A5005666807 @default.
- W2956149178 creator A5008693135 @default.
- W2956149178 creator A5013072436 @default.
- W2956149178 creator A5017459737 @default.
- W2956149178 creator A5022815796 @default.
- W2956149178 creator A5048898414 @default.
- W2956149178 creator A5062755510 @default.
- W2956149178 creator A5073311956 @default.
- W2956149178 creator A5083895190 @default.
- W2956149178 creator A5087587237 @default.
- W2956149178 date "2019-07-04" @default.
- W2956149178 modified "2023-10-14" @default.
- W2956149178 title "Mussel-Inspired Hydrogel with Potent <i>in Vivo</i> Contact-Active Antimicrobial and Wound Healing Promoting Activities" @default.
- W2956149178 cites W1760709408 @default.
- W2956149178 cites W1907702098 @default.
- W2956149178 cites W1947749409 @default.
- W2956149178 cites W1970356261 @default.
- W2956149178 cites W2004708512 @default.
- W2956149178 cites W2010204626 @default.
- W2956149178 cites W2026954356 @default.
- W2956149178 cites W2035248785 @default.
- W2956149178 cites W2052230840 @default.
- W2956149178 cites W2052698912 @default.
- W2956149178 cites W2054602599 @default.
- W2956149178 cites W2056064788 @default.
- W2956149178 cites W2058067017 @default.
- W2956149178 cites W2095597734 @default.
- W2956149178 cites W2095805080 @default.
- W2956149178 cites W2111510685 @default.
- W2956149178 cites W2111893100 @default.
- W2956149178 cites W2118079497 @default.
- W2956149178 cites W2122721391 @default.
- W2956149178 cites W2124784086 @default.
- W2956149178 cites W2132822777 @default.
- W2956149178 cites W2153266910 @default.
- W2956149178 cites W2155572331 @default.
- W2956149178 cites W2159108851 @default.
- W2956149178 cites W2205832286 @default.
- W2956149178 cites W2264623950 @default.
- W2956149178 cites W2285654014 @default.
- W2956149178 cites W2301044272 @default.
- W2956149178 cites W2312342438 @default.
- W2956149178 cites W2312720395 @default.
- W2956149178 cites W2324730467 @default.
- W2956149178 cites W2554589023 @default.
- W2956149178 cites W2560626154 @default.
- W2956149178 cites W2574180453 @default.
- W2956149178 cites W2583044859 @default.
- W2956149178 cites W2589216136 @default.
- W2956149178 cites W2598502678 @default.
- W2956149178 cites W2605875532 @default.
- W2956149178 cites W2613102646 @default.
- W2956149178 cites W2613286058 @default.
- W2956149178 cites W2623085684 @default.
- W2956149178 cites W2746188371 @default.
- W2956149178 cites W2750226384 @default.
- W2956149178 cites W2760736626 @default.
- W2956149178 cites W2761821009 @default.
- W2956149178 cites W2782435806 @default.
- W2956149178 cites W2785159061 @default.
- W2956149178 cites W2788009719 @default.
- W2956149178 cites W2788081998 @default.
- W2956149178 cites W2791135579 @default.
- W2956149178 cites W2791600221 @default.
- W2956149178 cites W2794372602 @default.
- W2956149178 cites W2800093708 @default.
- W2956149178 cites W2806499735 @default.
- W2956149178 cites W2807118216 @default.
- W2956149178 cites W2808332114 @default.
- W2956149178 cites W2884934086 @default.
- W2956149178 cites W2900540898 @default.
- W2956149178 cites W2903236462 @default.
- W2956149178 cites W2903975202 @default.
- W2956149178 cites W2904902664 @default.
- W2956149178 cites W2905135547 @default.
- W2956149178 cites W2913060388 @default.
- W2956149178 cites W2944739651 @default.
- W2956149178 cites W4211196871 @default.
- W2956149178 doi "https://doi.org/10.1021/acsabm.9b00353" @default.
- W2956149178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35030775" @default.
- W2956149178 hasPublicationYear "2019" @default.
- W2956149178 type Work @default.
- W2956149178 sameAs 2956149178 @default.
- W2956149178 citedByCount "53" @default.
- W2956149178 countsByYear W29561491782019 @default.
- W2956149178 countsByYear W29561491782020 @default.
- W2956149178 countsByYear W29561491782021 @default.
- W2956149178 countsByYear W29561491782022 @default.
- W2956149178 countsByYear W29561491782023 @default.
- W2956149178 crossrefType "journal-article" @default.
- W2956149178 hasAuthorship W2956149178A5005666807 @default.
- W2956149178 hasAuthorship W2956149178A5008693135 @default.
- W2956149178 hasAuthorship W2956149178A5013072436 @default.
- W2956149178 hasAuthorship W2956149178A5017459737 @default.
- W2956149178 hasAuthorship W2956149178A5022815796 @default.
- W2956149178 hasAuthorship W2956149178A5048898414 @default.