FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956151805> ?p ?o ?g. }

• W2956151805 abstract "Globally, about 2 million people are diagnosed with lung cancer annually, making it the most common type of cancer in the world. In addition, lung cancer is the leading cause of cancer death among both men and women, accounting for ~25% of all cancer deaths in the United States and ~19% of cancer deaths worldwide. Although tobacco smoking is the most common cause of lung cancer, it is estimated that 10-25% of all patients diagnosed with lung cancer worldwide are never smokers, with higher proportions in Asians and women. Compared to former and current smokers with lung cancer, lung cancers in never smokers tend to present at an earlier age and more frequently have adenocarcinoma histology. Although a few risk factors are known to contribute to the etiology of lung cancer in never smokers, a large fraction of cancer cases cannot be explained by established environmental and genetic risk factors, highlighting the need for research in this area. One promising approach to identify the etiological factors involved in lung tumorigenesis in never smokers is based on the study of the “mutational signatures” that the exogenous and endogenous processes leave on the tumor tissue and surrounding areas. Somatic mutations accumulate throughout individuals’ lifetime, as a result of the balance between DNA damage and DNA repair. Mutational sources can change over time and mutational signatures can provide information on the tumor evolutionary trajectory, tracking activities of mutational processes. We designed “Sherlock-Lung” to identify mutational signatures in lung cancers from never smokers and order them based on their clonal and subclonal localization to have an insight on the factors involved in the initiation of the tumors. Prevention and treatment strategies are likely to be more effective when targeting the tumor initiating factors rather than those responsible for the tumor progression. Here, we present the Sherlock-Lung study design, which includes a combination of lung cancer cases from populations highly exposed to lung cancer risk factors and populations with unknown exposures. We also present preliminary data from this study and what we have learned from whole genome sequencing analysis of the mutational landscape of lung cancers from smokers and nonsmokers and from different histological subtypes. For example, although the mutational signature associated with tobacco smoking is largely clonal in all lung cancers from smokers, consistent with an initiating role of tobacco smoking in lung tumorigenesis, the mutational signatures distribution varies across histological subtypes. Moreover, the frequency of mutations in major cancer driver genes varies dramatically between smokers and never smokers, and mutational signatures distribution appears to differ between tumors with and without specific driver genes. In never smokers, without the dominant mutational source of tobacco smoking, other signatures emerged, e.g., that associated with reactive oxygen species. Although this approach has already revealed important information on the etiological processes involved in tumorigenesis of lung cancer and other cancer types, there is a growing list of open questions and challenges that need to be addressed. In population studies, careful exposure assessment to identify and validate new mutational signatures and the inclusion of study subjects from different geographical locations and ethnicities are critical. Citation Format: Maria Teresa Landi, Tongwu Zhang, Montserrat Garcia-Closas, Yohan Bosse, Jianxin Shi, Bin Zhu, Qing Lan, Nathaniel Rothman, Jiyeon Choi, Neil E. Caporaso, Wei Zhao, Chongyi Chen, Eytan Ruppin, Jennifer Rosenbaum, Dmitry Gordenin, Sai Yendamuri, Chris Amos, Paul Brennan, David C. Christiani, Geoff Liu, Bonnie Gould Rothberg, Matthew Schabath, Han Liang, Ludmil Alexandrov, David Wedge, Stephen Chanock. Sherlock-Lung: Tracing lung cancer mutational processes in never smokers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY26-02." @default.
• W2956151805 created "2019-07-12" @default.
• W2956151805 creator A5001258652 @default.
• W2956151805 creator A5002151021 @default.
• W2956151805 creator A5002463978 @default.
• W2956151805 creator A5006802038 @default.
• W2956151805 creator A5013186571 @default.
• W2956151805 creator A5018773200 @default.
• W2956151805 creator A5019329822 @default.
• W2956151805 creator A5020639973 @default.
• W2956151805 creator A5023290111 @default.
• W2956151805 creator A5023531951 @default.
• W2956151805 creator A5034135495 @default.
• W2956151805 creator A5036246907 @default.
• W2956151805 creator A5048679350 @default.
• W2956151805 creator A5051424102 @default.
• W2956151805 creator A5053104107 @default.
• W2956151805 creator A5063492133 @default.
• W2956151805 creator A5064882380 @default.
• W2956151805 creator A5066732415 @default.
• W2956151805 creator A5066835564 @default.
• W2956151805 creator A5076591561 @default.
• W2956151805 creator A5076808228 @default.
• W2956151805 creator A5077109568 @default.
• W2956151805 creator A5084458604 @default.
• W2956151805 creator A5091331939 @default.
• W2956151805 creator A5091653870 @default.
• W2956151805 creator A5091859226 @default.
• W2956151805 date "2019-07-01" @default.
• W2956151805 modified "2023-10-03" @default.
• W2956151805 title "Abstract SY26-02:Sherlock-Lung: Tracing lung cancer mutational processes in never smokers" @default.
• W2956151805 doi "https://doi.org/10.1158/1538-7445.sabcs18-sy26-02" @default.
• W2956151805 hasPublicationYear "2019" @default.
• W2956151805 type Work @default.
• W2956151805 sameAs 2956151805 @default.
• W2956151805 citedByCount "0" @default.
• W2956151805 crossrefType "proceedings-article" @default.
• W2956151805 hasAuthorship W2956151805A5001258652 @default.
• W2956151805 hasAuthorship W2956151805A5002151021 @default.
• W2956151805 hasAuthorship W2956151805A5002463978 @default.
• W2956151805 hasAuthorship W2956151805A5006802038 @default.
• W2956151805 hasAuthorship W2956151805A5013186571 @default.
• W2956151805 hasAuthorship W2956151805A5018773200 @default.
• W2956151805 hasAuthorship W2956151805A5019329822 @default.
• W2956151805 hasAuthorship W2956151805A5020639973 @default.
• W2956151805 hasAuthorship W2956151805A5023290111 @default.
• W2956151805 hasAuthorship W2956151805A5023531951 @default.
• W2956151805 hasAuthorship W2956151805A5034135495 @default.
• W2956151805 hasAuthorship W2956151805A5036246907 @default.
• W2956151805 hasAuthorship W2956151805A5048679350 @default.
• W2956151805 hasAuthorship W2956151805A5051424102 @default.
• W2956151805 hasAuthorship W2956151805A5053104107 @default.
• W2956151805 hasAuthorship W2956151805A5063492133 @default.
• W2956151805 hasAuthorship W2956151805A5064882380 @default.
• W2956151805 hasAuthorship W2956151805A5066732415 @default.
• W2956151805 hasAuthorship W2956151805A5066835564 @default.
• W2956151805 hasAuthorship W2956151805A5076591561 @default.
• W2956151805 hasAuthorship W2956151805A5076808228 @default.
• W2956151805 hasAuthorship W2956151805A5077109568 @default.
• W2956151805 hasAuthorship W2956151805A5084458604 @default.
• W2956151805 hasAuthorship W2956151805A5091331939 @default.
• W2956151805 hasAuthorship W2956151805A5091653870 @default.
• W2956151805 hasAuthorship W2956151805A5091859226 @default.
• W2956151805 hasConcept C121608353 @default.
• W2956151805 hasConcept C126322002 @default.
• W2956151805 hasConcept C137627325 @default.
• W2956151805 hasConcept C142724271 @default.
• W2956151805 hasConcept C143998085 @default.
• W2956151805 hasConcept C2776256026 @default.
• W2956151805 hasConcept C2777714996 @default.
• W2956151805 hasConcept C2781182431 @default.
• W2956151805 hasConcept C555283112 @default.
• W2956151805 hasConcept C60644358 @default.
• W2956151805 hasConcept C71924100 @default.
• W2956151805 hasConcept C86803240 @default.
• W2956151805 hasConceptScore W2956151805C121608353 @default.
• W2956151805 hasConceptScore W2956151805C126322002 @default.
• W2956151805 hasConceptScore W2956151805C137627325 @default.
• W2956151805 hasConceptScore W2956151805C142724271 @default.
• W2956151805 hasConceptScore W2956151805C143998085 @default.
• W2956151805 hasConceptScore W2956151805C2776256026 @default.
• W2956151805 hasConceptScore W2956151805C2777714996 @default.
• W2956151805 hasConceptScore W2956151805C2781182431 @default.
• W2956151805 hasConceptScore W2956151805C555283112 @default.
• W2956151805 hasConceptScore W2956151805C60644358 @default.
• W2956151805 hasConceptScore W2956151805C71924100 @default.
• W2956151805 hasConceptScore W2956151805C86803240 @default.
• W2956151805 hasLocation W29561518051 @default.
• W2956151805 hasOpenAccess W2956151805 @default.
• W2956151805 hasPrimaryLocation W29561518051 @default.
• W2956151805 hasRelatedWork W1487799282 @default.
• W2956151805 hasRelatedWork W1509965220 @default.
• W2956151805 hasRelatedWork W158892140 @default.
• W2956151805 hasRelatedWork W1628034222 @default.
• W2956151805 hasRelatedWork W1971914946 @default.
• W2956151805 hasRelatedWork W2060491830 @default.
• W2956151805 hasRelatedWork W2099787506 @default.
• W2956151805 hasRelatedWork W2128936130 @default.
• W2956151805 hasRelatedWork W2129774558 @default.
• W2956151805 hasRelatedWork W2152735604 @default.

• next