FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956156218> ?p ?o ?g. }

• W2956156218 endingPage "112590" @default.
• W2956156218 startingPage "112590" @default.
• W2956156218 abstract "Preterm babies treated with synthetic glucocorticoids in utero exhibit behavioural alterations and disturbances in brain maturation during postnatal life. Accordingly, it has been shown in preclinical studies that SGC exposure at a clinical dose alters the presynaptic and postsynaptic structures and results in synaptic impairments. However, the precise mechanism by which SGC exposure impairs synaptic protein expression and its implications are not fully elucidated. Therefore, the purpose of this study was to investigate the effect of prenatal exposure to a clinical dose of betamethasone on the pre- and postsynaptic proteins expression in the developing rat cerebellum and prefrontal cortex, whose synchronized synaptic activity is crucial for motor control and learning. Consequently, the first objective of the present study was to determine whether prenatal betamethasone -equivalent to the clinically used dose- alters cerebellar vermal and cortical expression of synaptophysin, synaptotagmin I, post-synaptic density protein 95 and gephyrin - four important pre- and post-synaptic proteins, respectively- at a relevant adolescent stage. In addition, our second objective was to assess whether prenatal betamethasone administration induced coordination impairment using a rotarod test. On the other hand, it has been shown that the environmental enrichment is capable of improving synaptic transmission and recovering various behavioural impairments. Nevertheless, there is not enough information about the effect of this non-pharmacological preclinical approach on the regulation of this cerebellar and cortical synaptic proteins. Therefore, the third objective of this study was to examine whether environmental enrichment exposure could recover the possible molecular and behavioural impairments in the offspring at the same developmental stage. The principal data showed that adolescent rats prenatally treated with betamethasone exhibited underexpression of synaptophysin in the vermal cerebellum, but not change in levels of synaptotagmin I, post-synaptic density protein 95 and gephyrin. Analysis of the same pre- and post-synaptic proteins no showed differences in the frontal cortex of the same rats. These results were accompanied by an increase in the number of falls in the rotarod test, when the speed of rotation was fixed and when it was in acceleration, which means motor coordination impairments. Importantly, we found that environmental enrichment restores the betamethasone-induced reduction in the cerebellar synaptophysin together with a recover in the motor coordination impairments in prenatally betamethasone-exposed adolescent rats." @default.
• W2956156218 created "2019-07-12" @default.
• W2956156218 creator A5008004390 @default.
• W2956156218 creator A5015962811 @default.
• W2956156218 creator A5016030953 @default.
• W2956156218 creator A5016774200 @default.
• W2956156218 creator A5027963590 @default.
• W2956156218 creator A5061747700 @default.
• W2956156218 creator A5077699437 @default.
• W2956156218 creator A5084001212 @default.
• W2956156218 date "2019-10-01" @default.
• W2956156218 modified "2023-09-27" @default.
• W2956156218 title "Environmental enrichment restores the reduced expression of cerebellar synaptophysin and the motor coordination impairment in rats prenatally treated with betamethasone" @default.
• W2956156218 cites W1493326255 @default.
• W2956156218 cites W1519398151 @default.
• W2956156218 cites W1593010045 @default.
• W2956156218 cites W1860351382 @default.
• W2956156218 cites W1956859686 @default.
• W2956156218 cites W1966667764 @default.
• W2956156218 cites W1970770411 @default.
• W2956156218 cites W1970941802 @default.
• W2956156218 cites W1972262414 @default.
• W2956156218 cites W1974173805 @default.
• W2956156218 cites W1974672164 @default.
• W2956156218 cites W1979676825 @default.
• W2956156218 cites W1980904541 @default.
• W2956156218 cites W1989791787 @default.
• W2956156218 cites W1992507666 @default.
• W2956156218 cites W1993511889 @default.
• W2956156218 cites W1994146809 @default.
• W2956156218 cites W1994225685 @default.
• W2956156218 cites W1997997010 @default.
• W2956156218 cites W1999935557 @default.
• W2956156218 cites W2005191507 @default.
• W2956156218 cites W2028493450 @default.
• W2956156218 cites W2032607014 @default.
• W2956156218 cites W2040347331 @default.
• W2956156218 cites W2046641753 @default.
• W2956156218 cites W2058734125 @default.
• W2956156218 cites W2058873342 @default.
• W2956156218 cites W2062564862 @default.
• W2956156218 cites W2067570041 @default.
• W2956156218 cites W2067651721 @default.
• W2956156218 cites W2068477930 @default.
• W2956156218 cites W2073508673 @default.
• W2956156218 cites W2074148726 @default.
• W2956156218 cites W2078702757 @default.
• W2956156218 cites W2082115578 @default.
• W2956156218 cites W2085238148 @default.
• W2956156218 cites W2088505072 @default.
• W2956156218 cites W2095021214 @default.
• W2956156218 cites W2100448337 @default.
• W2956156218 cites W2106308939 @default.
• W2956156218 cites W2109774554 @default.
• W2956156218 cites W2113735925 @default.
• W2956156218 cites W2114330799 @default.
• W2956156218 cites W2132292508 @default.
• W2956156218 cites W2138495658 @default.
• W2956156218 cites W2138872551 @default.
• W2956156218 cites W2141621434 @default.
• W2956156218 cites W2142997679 @default.
• W2956156218 cites W2178892099 @default.
• W2956156218 cites W2232050196 @default.
• W2956156218 cites W2233595448 @default.
• W2956156218 cites W2326867759 @default.
• W2956156218 cites W2404837516 @default.
• W2956156218 cites W2473662715 @default.
• W2956156218 cites W2513640185 @default.
• W2956156218 cites W2555515755 @default.
• W2956156218 cites W2583458131 @default.
• W2956156218 cites W2599052511 @default.
• W2956156218 cites W2619395949 @default.
• W2956156218 cites W2626993252 @default.
• W2956156218 cites W2793364121 @default.
• W2956156218 cites W2800350578 @default.
• W2956156218 cites W2800471507 @default.
• W2956156218 cites W2810860799 @default.
• W2956156218 cites W2838498153 @default.
• W2956156218 cites W2883657578 @default.
• W2956156218 cites W2884415520 @default.
• W2956156218 cites W2900010964 @default.
• W2956156218 doi "https://doi.org/10.1016/j.physbeh.2019.112590" @default.
• W2956156218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31252027" @default.
• W2956156218 hasPublicationYear "2019" @default.
• W2956156218 type Work @default.
• W2956156218 sameAs 2956156218 @default.
• W2956156218 citedByCount "5" @default.
• W2956156218 countsByYear W29561562182022 @default.
• W2956156218 crossrefType "journal-article" @default.
• W2956156218 hasAuthorship W2956156218A5008004390 @default.
• W2956156218 hasAuthorship W2956156218A5015962811 @default.
• W2956156218 hasAuthorship W2956156218A5016030953 @default.
• W2956156218 hasAuthorship W2956156218A5016774200 @default.
• W2956156218 hasAuthorship W2956156218A5027963590 @default.
• W2956156218 hasAuthorship W2956156218A5061747700 @default.
• W2956156218 hasAuthorship W2956156218A5077699437 @default.
• W2956156218 hasAuthorship W2956156218A5084001212 @default.
• W2956156218 hasConcept C112592302 @default.

• next