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- W2956158086 abstract "Once HIV enters the lymphoid organs, exponential viral replication in T cells ensues. Given the densely packed nature of these tissues, where infected and uninfected cells are in nearly constant contact with one another, efficient HIV spread is thought to occur through cell-cell contacts in vivo . However, this has not been formally demonstrated. In this study, we performed live-cell imaging studies within a 3-dimensional space to recapitulate the dynamic aspects of the lymphoid microenvironment and asked whether HIV can alter the morphology, migration capacity, and cell-cell contact behaviors between macrophages and T cells. We show that HIV-infected macrophages can engage T cells in stable contacts through binding of virus- and host-derived adhesive molecules and that stable macrophage-T cell contacts were required for high viral spread. Thus, HIV alters physiological macrophage-T cell interactions in order to access and restrain large numbers of susceptible, motile T cells, thereby playing an important role in HIV progression." @default.
- W2956158086 created "2019-07-12" @default.
- W2956158086 creator A5038573763 @default.
- W2956158086 creator A5061635112 @default.
- W2956158086 creator A5072200033 @default.
- W2956158086 creator A5080358282 @default.
- W2956158086 date "2019-09-15" @default.
- W2956158086 modified "2023-10-10" @default.
- W2956158086 title "HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread" @default.
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