Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956160625> ?p ?o ?g. }
- W2956160625 endingPage "299" @default.
- W2956160625 startingPage "237" @default.
- W2956160625 abstract "The peptidoglycan is the key structural component of the bacterial cell wall that rests outside the cytoplasmic membrane and provides bacterial cells with physical strength and shape. It constitutes a huge mesh-like macromolecule composed of linear glycans held together by short peptides: the glycans consist of alternating amino sugars, N-acetylglucosamine (GlcNAc), and N-acetylmuramic acid (MurNAc), connected by β-1,4-glycosidic linkages, and the peptides include noncanonical d-amino acids and cross-link the glycan chains via binding to MurNAc. The peptidoglycan macromolecule is ubiquitous in bacteria, regardless of whether displaying a Gram-positive, Gram-negative, or complex mycobacterial cell envelope structure, and it is also highly restricted to bacteria, thereby distinguishing bacteria from eukaryotic microorganisms and archaea. In all bacteria, the peptidoglycan is synthesized from a lipid-anchored precursor that is preformed in the cytoplasm, flipped outward through the plasma membrane by channeling proteins (flippasesFlippase), and is finally polymerized by membrane-bound, outward-facing synthetic enzymes (glycosyltransferases Glycosyltransferase (GT) and transpeptidasesTranspeptidase (TP)) building a net-shaped covering of the entire bacterial cell, called the peptidoglycan sacculusSacculus. The peptidoglycan sacculus allows bacteria to cope with osmotic and environmental challenges, and it secures cell integrity during all stages of bacterial growth. It has to be sufficiently strong and rigid but, at the same time, flexible and dynamic to assure integrity of the cell during enlargement, division, and differentiation processes. Thus, the synthesis and integrity of the peptidoglycan are major targets of antibacterial therapeutics. We are summarizing in this chapter present knowledge including recent discoveries of peptidoglycan structure, assembly, and dynamics during bacterial growth." @default.
- W2956160625 created "2019-07-12" @default.
- W2956160625 creator A5049863011 @default.
- W2956160625 creator A5071526929 @default.
- W2956160625 date "2019-01-01" @default.
- W2956160625 modified "2023-10-10" @default.
- W2956160625 title "Peptidoglycan Structure, Biosynthesis, and Dynamics During Bacterial Growth" @default.
- W2956160625 cites W1034366565 @default.
- W2956160625 cites W110298407 @default.
- W2956160625 cites W1478816797 @default.
- W2956160625 cites W1483293912 @default.
- W2956160625 cites W1487593985 @default.
- W2956160625 cites W1491592183 @default.
- W2956160625 cites W1498555668 @default.
- W2956160625 cites W1499651267 @default.
- W2956160625 cites W1505479679 @default.
- W2956160625 cites W1510047560 @default.
- W2956160625 cites W1513439761 @default.
- W2956160625 cites W1513723427 @default.
- W2956160625 cites W1518819654 @default.
- W2956160625 cites W1520028347 @default.
- W2956160625 cites W1525864817 @default.
- W2956160625 cites W1531224987 @default.
- W2956160625 cites W1554712188 @default.
- W2956160625 cites W1570270309 @default.
- W2956160625 cites W1577032310 @default.
- W2956160625 cites W1577276587 @default.
- W2956160625 cites W1588161749 @default.
- W2956160625 cites W1601796453 @default.
- W2956160625 cites W1676178724 @default.
- W2956160625 cites W1684334462 @default.
- W2956160625 cites W1723438040 @default.
- W2956160625 cites W1755057697 @default.
- W2956160625 cites W1809447830 @default.
- W2956160625 cites W1835426283 @default.
- W2956160625 cites W1839573617 @default.
- W2956160625 cites W1849927510 @default.
- W2956160625 cites W1856982212 @default.
- W2956160625 cites W1919928164 @default.
- W2956160625 cites W1923615078 @default.
- W2956160625 cites W1924975182 @default.
- W2956160625 cites W1931984331 @default.
- W2956160625 cites W1959649751 @default.
- W2956160625 cites W1964601681 @default.
- W2956160625 cites W1964630790 @default.
- W2956160625 cites W1964832282 @default.
- W2956160625 cites W1964854182 @default.
- W2956160625 cites W1965760881 @default.
- W2956160625 cites W1966070420 @default.
- W2956160625 cites W1966626967 @default.
- W2956160625 cites W1967703752 @default.
- W2956160625 cites W1968425270 @default.
- W2956160625 cites W1968718809 @default.
- W2956160625 cites W1968723178 @default.
- W2956160625 cites W1968790130 @default.
- W2956160625 cites W1969099233 @default.
- W2956160625 cites W1969972591 @default.
- W2956160625 cites W1972747519 @default.
- W2956160625 cites W1975436949 @default.
- W2956160625 cites W1975906315 @default.
- W2956160625 cites W1975943954 @default.
- W2956160625 cites W1977568111 @default.
- W2956160625 cites W1977621139 @default.
- W2956160625 cites W1977950017 @default.
- W2956160625 cites W1979404035 @default.
- W2956160625 cites W1981039934 @default.
- W2956160625 cites W1981449487 @default.
- W2956160625 cites W1981723997 @default.
- W2956160625 cites W1982015602 @default.
- W2956160625 cites W1982705370 @default.
- W2956160625 cites W1982843047 @default.
- W2956160625 cites W1982889726 @default.
- W2956160625 cites W1983287860 @default.
- W2956160625 cites W1983344500 @default.
- W2956160625 cites W1984242772 @default.
- W2956160625 cites W1985744248 @default.
- W2956160625 cites W1986630778 @default.
- W2956160625 cites W1986781700 @default.
- W2956160625 cites W1987167682 @default.
- W2956160625 cites W1987530419 @default.
- W2956160625 cites W1988872938 @default.
- W2956160625 cites W1989717746 @default.
- W2956160625 cites W1993171194 @default.
- W2956160625 cites W1994909642 @default.
- W2956160625 cites W1995405638 @default.
- W2956160625 cites W1995500412 @default.
- W2956160625 cites W1996639976 @default.
- W2956160625 cites W1998188317 @default.
- W2956160625 cites W1999023596 @default.
- W2956160625 cites W1999404678 @default.
- W2956160625 cites W1999475434 @default.
- W2956160625 cites W2000214816 @default.
- W2956160625 cites W2000426297 @default.
- W2956160625 cites W2000777444 @default.
- W2956160625 cites W2001915879 @default.
- W2956160625 cites W2002170620 @default.
- W2956160625 cites W2002400362 @default.
- W2956160625 cites W2003144417 @default.