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• W2956162008 abstract "Banana is one of the most widely consumed fruits in the world. However, information regarding its health effects is scarce. Biomarkers of banana intake would allow a more accurate assessment of its consumption in nutrition studies.Using an untargeted metabolomics approach, we aimed to identify the banana-derived metabolites present in urine after consumption, including new candidate biomarkers of banana intake.A randomized controlled study with a crossover design was performed on 12 healthy subjects (6 men, 6 women, mean ± SD age: 30.0 ± 4.9 y; mean ± SD BMI: 22.5 ± 2.3 kg/m2). Subjects underwent 2 dietary interventions: 1) 250 mL control drink (Fresubin 2 kcal fiber, neutral flavor; Fresenius Kabi), and 2) 240 g banana + 150 mL control drink. Twenty-four-hour urine samples were collected and analyzed with ultra-performance liquid chromatography coupled to a quadrupole time-of-flight MS and 2-dimensional GC-MS. The discovered biomarkers were confirmed in a cross-sectional study [KarMeN (Karlsruhe Metabolomics and Nutrition study)] in which 78 subjects (mean BMI: 22.8; mean age: 47 y) were selected reflecting high intake (126-378 g/d), low intake (47.3-94.5 g/d), and nonconsumption of banana. The confirmed biomarkers were examined singly or in combinations, for established criteria of validation for biomarkers of food intake.We identified 33 potentially bioactive banana metabolites, of which 5 metabolites, methoxyeugenol glucuronide (MEUG-GLUC), dopamine sulfate (DOP-S), salsolinol sulfate, xanthurenic acid, and 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline sulfate, were confirmed as candidate intake biomarkers. We demonstrated that the combination of MEUG-GLUC and DOP-S performed best in predicting banana intake in high (AUCtest = 0.92) and low (AUCtest = 0.87) consumers. The new biomarkers met key criteria establishing their current applicability in nutrition and health research for assessing the occurrence of banana intake.Our metabolomics study in healthy men and women revealed new putative bioactive metabolites of banana and a combined biomarker of intake. These findings will help to better decipher the health effects of banana in future focused studies. This study was registered at clinicaltrials.gov as NCT03581955 and with the Ethical Committee for the Protection of Human Subjects Sud-Est 6 as CPP AU 1251, IDRCB 2016-A0013-48; the KarMeN study was registered with the German Clinical Trials Register (DRKS00004890). Details about the study can be obtained from https://www.drks.de." @default.
• W2956162008 created "2019-07-12" @default.
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• W2956162008 date "2019-10-01" @default.
• W2956162008 modified "2023-10-15" @default.
• W2956162008 title "Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies" @default.
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• W2956162008 cites W1832224854 @default.
• W2956162008 cites W1975420422 @default.
• W2956162008 cites W1987323108 @default.
• W2956162008 cites W1989234976 @default.
• W2956162008 cites W1994344086 @default.
• W2956162008 cites W1995968820 @default.
• W2956162008 cites W1996685836 @default.
• W2956162008 cites W2003768543 @default.
• W2956162008 cites W2004164125 @default.
• W2956162008 cites W2005013675 @default.
• W2956162008 cites W2006217599 @default.
• W2956162008 cites W2006766266 @default.
• W2956162008 cites W2010426235 @default.
• W2956162008 cites W2010615661 @default.
• W2956162008 cites W2016237346 @default.
• W2956162008 cites W2034726499 @default.
• W2956162008 cites W2036122093 @default.
• W2956162008 cites W2042395713 @default.
• W2956162008 cites W2050863543 @default.
• W2956162008 cites W2051107028 @default.
• W2956162008 cites W2051639587 @default.
• W2956162008 cites W2053288446 @default.
• W2956162008 cites W2053707938 @default.
• W2956162008 cites W2057523442 @default.
• W2956162008 cites W2060108668 @default.
• W2956162008 cites W2064855192 @default.
• W2956162008 cites W2084983919 @default.
• W2956162008 cites W2085892617 @default.
• W2956162008 cites W2090844063 @default.
• W2956162008 cites W2093186603 @default.
• W2956162008 cites W2096686533 @default.
• W2956162008 cites W2109963281 @default.
• W2956162008 cites W2120171195 @default.
• W2956162008 cites W2123221527 @default.
• W2956162008 cites W2128567308 @default.
• W2956162008 cites W2141405875 @default.
• W2956162008 cites W2147368905 @default.
• W2956162008 cites W2149309843 @default.
• W2956162008 cites W2155948158 @default.
• W2956162008 cites W2157706671 @default.
• W2956162008 cites W2168536943 @default.
• W2956162008 cites W2285662082 @default.
• W2956162008 cites W2293179256 @default.
• W2956162008 cites W2293873752 @default.
• W2956162008 cites W2460181513 @default.
• W2956162008 cites W2507359618 @default.
• W2956162008 cites W2540474045 @default.
• W2956162008 cites W2552476657 @default.
• W2956162008 cites W2580570975 @default.
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• W2956162008 cites W2617777814 @default.
• W2956162008 cites W2623027564 @default.
• W2956162008 cites W2766260610 @default.
• W2956162008 cites W2803615953 @default.
• W2956162008 cites W2805454228 @default.
• W2956162008 cites W2883042333 @default.
• W2956162008 cites W2891413025 @default.
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• W2956162008 doi "https://doi.org/10.1093/jn/nxz125" @default.
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