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- W2956163354 abstract "A platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand featuring an anthracenyl moiety was prepared. The compound was fully characterized and its molecular structure was determined by single-crystal X-ray diffraction. The compound demonstrated high in vitro antiproliferative activities against cancer cell lines with IC50 ranging from 10 to 80 nM. The presence of the anthracenyl moiety on the N-heterocyclic carbene (NHC) Pt complex was used as a luminescent tag to probe the metal interaction with the nucleobases of the DNA through a pyridine-nucleobase ligand exchange. Such interaction of the platinum complex with DNA was corroborated by optical tweezers techniques and liquid phase atomic force microscopy (AFM). The results revealed a two-state interaction between the platinum complex and the DNA strands. This two-state behavior was quantified from the different experiments due to contour length variations. At 24 h incubation, the stretching curves revealed multiple structural breakages, and AFM imaging revealed a highly compact and dense structure of platinum complexes bridging the DNA strands." @default.
- W2956163354 created "2019-07-23" @default.
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- W2956163354 creator A5077682751 @default.
- W2956163354 date "2019-08-27" @default.
- W2956163354 modified "2023-10-17" @default.
- W2956163354 title "N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction" @default.
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- W2956163354 doi "https://doi.org/10.3390/ijms20174198" @default.
- W2956163354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6747518" @default.
- W2956163354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31461928" @default.
- W2956163354 hasPublicationYear "2019" @default.
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