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- W2956164631 abstract "The effect of the 15 amino-acid residue proline rich polypeptide (PRP) (AGAPEPAEPAQPGVY, 1475 Da) on the interaction in vitro between coagulation factor Xa (FXa) and the primary naturally occurring inhibitor of FXa, antithrombin III (ATIII) was studied via SDS-PAGE. PRP appears to have a biphasic affect on the FXa-ATIII complex. A scheme was proposed to address the transformations of FXaa to FXaβ, and transformations of primary (1°) FXa-ATIII complexes to the secondary (2°) and tertiary (3°) complexes, based upon SDS-PAGE and Western Blot identification of protein bands and products. PRP (8 μg) profoundly promoted the transformation of FXaα to FXaβ and the further transformation of 1° FXaβ-ATIII complex to 3° FXaβ-ATIII complex, as well as production of FXay. In contrast, 4 μg PRP inhibited transformation of FXaα to FXaβ as well as that of 1° FXaα-ATIII to 3° FXaα-ATIII and of 1° FXaβ-ATIII to 3° FXaβ-ATIII. A pharmacological role for PRP in the molecular mechanisms of blood clotting has thus been proposed." @default.
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- W2956164631 date "2004-01-01" @default.
- W2956164631 modified "2023-09-24" @default.
- W2956164631 title "INTERACTIONS OF NEUROPEPTIDES WITH COAGULATION CASCADE COMPONENTS; A POTENTIAL ROLE FOR PROLINE-RICH POLYPEPTIDE IN THE METABOLISM OF FACTOR XA/ANTITHROMBIN III COMPLEX" @default.
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