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• W2956188660 endingPage "2030" @default.
• W2956188660 startingPage "2010" @default.
• W2956188660 abstract "Development of chemoresistance remains a major challenge in treating esophageal squamous cell carcinoma (ESCC) patients despite treatment advances. However, the role of RAC1 in chemoresistance of ESCC and the underlying mechanisms remain largely unknown. In this study, we found that higher levels of RAC1 expression were associated with poorer prognosis in ESCC patients. Enhanced RAC1 expression increased cell proliferation, migration, and chemoresistance in vitro. Combination therapy using RAC1 inhibitor EHop-016 and cisplatin significantly promoted cell viability inhibition, G2/M phase cycle arrest, and apoptosis when compared to each monotherapy. Mechanistically, glycolysis was significantly downregulated in the RAC1 inhibitor monotherapy group and the combination group via inhibiting AKT/FOXO3a signaling when compared to the control group. Moreover, the silencing of RAC1 inhibited AKT/FOXO3a signaling and cell glycolysis while the upregulation of RAC1 produced an opposite effect. In murine xenograft models, the tumor volume and the expression of glycolytic enzymes were significantly reduced in combination therapy when compared to each monotherapy group. Overall, our study demonstrates that targeting RAC1 with an inhibitor overcomes cisplatin resistance in ESCC by suppressing glycolytic enzymes, which provides a promising strategy for treatment of ESCC in clinical practice." @default.
• W2956188660 created "2019-07-23" @default.
• W2956188660 creator A5023539148 @default.
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• W2956188660 date "2019-07-27" @default.
• W2956188660 modified "2023-10-16" @default.
• W2956188660 title "RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes" @default.
• W2956188660 cites W1495406308 @default.
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• W2956188660 cites W1581731557 @default.
• W2956188660 cites W1584683704 @default.
• W2956188660 cites W1587496317 @default.
• W2956188660 cites W1668086213 @default.
• W2956188660 cites W1841640992 @default.
• W2956188660 cites W1893330971 @default.
• W2956188660 cites W1964521034 @default.
• W2956188660 cites W1975964180 @default.
• W2956188660 cites W1976402722 @default.
• W2956188660 cites W1979699711 @default.
• W2956188660 cites W1979779590 @default.
• W2956188660 cites W1987058957 @default.
• W2956188660 cites W1989939191 @default.
• W2956188660 cites W1993829758 @default.
• W2956188660 cites W2002226709 @default.
• W2956188660 cites W2003944475 @default.
• W2956188660 cites W2009999719 @default.
• W2956188660 cites W2014640795 @default.
• W2956188660 cites W2018103000 @default.
• W2956188660 cites W2018631917 @default.
• W2956188660 cites W2019528050 @default.
• W2956188660 cites W2021904626 @default.
• W2956188660 cites W2024590066 @default.
• W2956188660 cites W2027859848 @default.
• W2956188660 cites W2041156138 @default.
• W2956188660 cites W2041405844 @default.
• W2956188660 cites W2043671423 @default.
• W2956188660 cites W2047448000 @default.
• W2956188660 cites W2051719011 @default.
• W2956188660 cites W2052565988 @default.
• W2956188660 cites W2059019158 @default.
• W2956188660 cites W206414211 @default.
• W2956188660 cites W2068243592 @default.
• W2956188660 cites W2073496037 @default.
• W2956188660 cites W2080411308 @default.
• W2956188660 cites W2087310747 @default.
• W2956188660 cites W2087973518 @default.
• W2956188660 cites W2090766239 @default.
• W2956188660 cites W2092585609 @default.
• W2956188660 cites W2099516272 @default.
• W2956188660 cites W2101698476 @default.
• W2956188660 cites W2103017472 @default.
• W2956188660 cites W2103569939 @default.
• W2956188660 cites W2106787323 @default.
• W2956188660 cites W2117028091 @default.
• W2956188660 cites W2117072485 @default.
• W2956188660 cites W2125508691 @default.
• W2956188660 cites W2131118073 @default.
• W2956188660 cites W2133465414 @default.
• W2956188660 cites W2139499629 @default.
• W2956188660 cites W2139503567 @default.
• W2956188660 cites W2142685635 @default.
• W2956188660 cites W2148559158 @default.
• W2956188660 cites W2149788186 @default.
• W2956188660 cites W2152239989 @default.
• W2956188660 cites W2155951732 @default.
• W2956188660 cites W2157540279 @default.
• W2956188660 cites W2158731289 @default.
• W2956188660 cites W2168828940 @default.
• W2956188660 cites W2179851135 @default.
• W2956188660 cites W2183609636 @default.
• W2956188660 cites W2204493619 @default.
• W2956188660 cites W2223535266 @default.
• W2956188660 cites W2224415831 @default.
• W2956188660 cites W2324970292 @default.
• W2956188660 cites W2401815452 @default.
• W2956188660 cites W2588156041 @default.
• W2956188660 cites W2608191634 @default.
• W2956188660 cites W2743283968 @default.
• W2956188660 cites W2748360223 @default.
• W2956188660 cites W2749884966 @default.
• W2956188660 cites W2889051002 @default.
• W2956188660 cites W337168599 @default.
• W2956188660 cites W4238567307 @default.
• W2956188660 cites W4322700634 @default.
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• W2956188660 doi "https://doi.org/10.1002/1878-0261.12548" @default.
• W2956188660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6717762" @default.
• W2956188660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31314174" @default.
• W2956188660 hasPublicationYear "2019" @default.
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