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- W2956199356 abstract "Secreted frizzled-related protein 4 (SFRP4) is a member of secreted protein family with sequence similarity to frizzled receptors of wingless-related integration site (Wnt) signaling pathways. These proteins control diverse functions from embryonic development to adults in many organisms including humans. Initially, SFRPs were recognized as antagonists of Wnt signaling and supposed to interact with Wnts. Further research demonstrated their interactions to frizzled receptors and a functional diversity was related to these proteins, Wnt signaling potentiation in addition to modulation. SFRP4 is the largest member of SFRP family and is implicated in many diseases including obesity, type 2 diabetes (T2D), and cancer. SFRP4 acts as a biomarker for T2D and was expressed several years before clinical diagnosis of disease. This review mainly focusses on the role of SFRP4 in obesity and how it can lead to β-cell failure and ultimately to T2D. The role of SFRP4 in adipose tissues causing increased production of adipokines lead to the oxidative stress in pancreas that particularly have low amount of antioxidant enzymes in pancreatic β-cells leading to failure in exocytosis of insulin containing granules causing T2D. Obesity-induced inflammation is a principal factor in pathogenesis of insulin resistance as well as metabolic syndrome. Pro-inflammatory cytokines have potential to cause insulin resistance in skeletal muscles, adipose tissue, and liver via inhibition of insulin signal transduction. Secretion of SFRP4 is mediated by interleukin 1-β (IL1-β). This review highlights the molecular mechanisms by which SFRP4 leads to T2D. Understanding of molecular mechanism and targeting SFRP4 could help to eradicate or reduce chances of developing T2D." @default.
- W2956199356 created "2019-07-23" @default.
- W2956199356 creator A5013268507 @default.
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- W2956199356 creator A5029938851 @default.
- W2956199356 creator A5043732331 @default.
- W2956199356 creator A5077221313 @default.
- W2956199356 date "2019-07-13" @default.
- W2956199356 modified "2023-09-30" @default.
- W2956199356 title "Secreted frizzled‐related protein 4 and its implication in obesity and type‐2 diabetes" @default.
- W2956199356 cites W1518164493 @default.
- W2956199356 cites W1568853114 @default.
- W2956199356 cites W1748011818 @default.
- W2956199356 cites W1956332901 @default.
- W2956199356 cites W1965141016 @default.
- W2956199356 cites W1966977991 @default.
- W2956199356 cites W1971829846 @default.
- W2956199356 cites W1975576923 @default.
- W2956199356 cites W1975853332 @default.
- W2956199356 cites W1979892459 @default.
- W2956199356 cites W1982709013 @default.
- W2956199356 cites W1988978046 @default.
- W2956199356 cites W1991866614 @default.
- W2956199356 cites W1993487095 @default.
- W2956199356 cites W1997999543 @default.
- W2956199356 cites W2001686316 @default.
- W2956199356 cites W2004872126 @default.
- W2956199356 cites W2006039088 @default.
- W2956199356 cites W2007355780 @default.
- W2956199356 cites W2013470723 @default.
- W2956199356 cites W2017563884 @default.
- W2956199356 cites W2018082082 @default.
- W2956199356 cites W2018448892 @default.
- W2956199356 cites W2027841291 @default.
- W2956199356 cites W2029094183 @default.
- W2956199356 cites W2030627501 @default.
- W2956199356 cites W2035958510 @default.
- W2956199356 cites W2036264366 @default.
- W2956199356 cites W2040432374 @default.
- W2956199356 cites W2043129312 @default.
- W2956199356 cites W2059467226 @default.
- W2956199356 cites W2059857664 @default.
- W2956199356 cites W2061488647 @default.
- W2956199356 cites W2064736822 @default.
- W2956199356 cites W2066549850 @default.
- W2956199356 cites W2078170297 @default.
- W2956199356 cites W2082676215 @default.
- W2956199356 cites W2088700535 @default.
- W2956199356 cites W2090704433 @default.
- W2956199356 cites W2095404298 @default.
- W2956199356 cites W2095574340 @default.
- W2956199356 cites W2095953860 @default.
- W2956199356 cites W2096611464 @default.
- W2956199356 cites W2102281174 @default.
- W2956199356 cites W2104682755 @default.
- W2956199356 cites W2105262555 @default.
- W2956199356 cites W2106330601 @default.
- W2956199356 cites W2115077956 @default.
- W2956199356 cites W2119284420 @default.
- W2956199356 cites W2124655787 @default.
- W2956199356 cites W2130693548 @default.
- W2956199356 cites W2135032786 @default.
- W2956199356 cites W2135902632 @default.
- W2956199356 cites W2143768875 @default.
- W2956199356 cites W2146257601 @default.
- W2956199356 cites W2150360138 @default.
- W2956199356 cites W2151690346 @default.
- W2956199356 cites W2155790711 @default.
- W2956199356 cites W2157486530 @default.
- W2956199356 cites W2164012871 @default.
- W2956199356 cites W2164356078 @default.
- W2956199356 cites W2165459158 @default.
- W2956199356 cites W2168581752 @default.
- W2956199356 cites W2282491007 @default.
- W2956199356 cites W2314758742 @default.
- W2956199356 cites W2322385389 @default.
- W2956199356 cites W2654257987 @default.
- W2956199356 cites W2794090318 @default.
- W2956199356 cites W2799802046 @default.
- W2956199356 cites W2801396070 @default.
- W2956199356 cites W2889276584 @default.
- W2956199356 cites W4294715705 @default.
- W2956199356 doi "https://doi.org/10.1002/iub.2123" @default.
- W2956199356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31301214" @default.
- W2956199356 hasPublicationYear "2019" @default.
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