FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956251012> ?p ?o ?g. }

• W2956251012 endingPage "2264" @default.
• W2956251012 startingPage "2252" @default.
• W2956251012 abstract "Abstract Domestication of wild animals induces a set of phenotypic characteristics collectively known as the domestication syndrome. However, how this syndrome emerges is still not clear. Recently, the neural crest cell deficit hypothesis proposed that it is generated by a mildly disrupted neural crest cell developmental program, but clear support is lacking due to the difficulties of distinguishing pure domestication effects from preexisting genetic differences between farmed and wild mammals and birds. Here, we use a farmed fish as model to investigate the role of persistent changes in DNA methylation (epimutations) in the process of domestication. We show that early domesticates of sea bass, with no genetic differences with wild counterparts, contain epimutations in tissues with different embryonic origins. About one fifth of epimutations that persist into adulthood are established by the time of gastrulation and affect genes involved in developmental processes that are expressed in embryonic structures, including the neural crest. Some of these genes are differentially expressed in sea bass with lower jaw malformations, a key feature of domestication syndrome. Interestingly, these epimutations significantly overlap with cytosine-to-thymine polymorphisms after 25 years of selective breeding. Furthermore, epimutated genes coincide with genes under positive selection in other domesticates. We argue that the initial stages of domestication include dynamic alterations in DNA methylation of developmental genes that affect the neural crest. Our results indicate a role for epimutations during the beginning of domestication that could be fixed as genetic variants and suggest a conserved molecular process to explain Darwin’s domestication syndrome across vertebrates." @default.
• W2956251012 created "2019-07-23" @default.
• W2956251012 creator A5005189798 @default.
• W2956251012 creator A5067350316 @default.
• W2956251012 date "2019-07-10" @default.
• W2956251012 modified "2023-10-14" @default.
• W2956251012 title "Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass" @default.
• W2956251012 cites W1492308969 @default.
• W2956251012 cites W1700570096 @default.
• W2956251012 cites W1770521942 @default.
• W2956251012 cites W1871958920 @default.
• W2956251012 cites W1878377624 @default.
• W2956251012 cites W1969353942 @default.
• W2956251012 cites W1973649102 @default.
• W2956251012 cites W1973795291 @default.
• W2956251012 cites W1976050935 @default.
• W2956251012 cites W1985604190 @default.
• W2956251012 cites W1989277387 @default.
• W2956251012 cites W1997476591 @default.
• W2956251012 cites W2005756834 @default.
• W2956251012 cites W2008224649 @default.
• W2956251012 cites W2033123297 @default.
• W2956251012 cites W2036046308 @default.
• W2956251012 cites W2049907774 @default.
• W2956251012 cites W2056907676 @default.
• W2956251012 cites W2069681519 @default.
• W2956251012 cites W2070050178 @default.
• W2956251012 cites W2072491205 @default.
• W2956251012 cites W2073839595 @default.
• W2956251012 cites W2077429965 @default.
• W2956251012 cites W2086808465 @default.
• W2956251012 cites W2091418877 @default.
• W2956251012 cites W2093261534 @default.
• W2956251012 cites W2096488278 @default.
• W2956251012 cites W2100091975 @default.
• W2956251012 cites W2102278945 @default.
• W2956251012 cites W2103017472 @default.
• W2956251012 cites W2103810926 @default.
• W2956251012 cites W2106889224 @default.
• W2956251012 cites W2108234281 @default.
• W2956251012 cites W2110905563 @default.
• W2956251012 cites W2119978637 @default.
• W2956251012 cites W2126434569 @default.
• W2956251012 cites W2131271579 @default.
• W2956251012 cites W2131374955 @default.
• W2956251012 cites W2132261072 @default.
• W2956251012 cites W2134266353 @default.
• W2956251012 cites W2138207763 @default.
• W2956251012 cites W2139122477 @default.
• W2956251012 cites W2145573418 @default.
• W2956251012 cites W2149992227 @default.
• W2956251012 cites W2150194502 @default.
• W2956251012 cites W2160697532 @default.
• W2956251012 cites W2162098634 @default.
• W2956251012 cites W2163327652 @default.
• W2956251012 cites W2165155571 @default.
• W2956251012 cites W2179438025 @default.
• W2956251012 cites W2180834397 @default.
• W2956251012 cites W2263792923 @default.
• W2956251012 cites W2276437132 @default.
• W2956251012 cites W2280053545 @default.
• W2956251012 cites W2299612718 @default.
• W2956251012 cites W2311093911 @default.
• W2956251012 cites W2345356016 @default.
• W2956251012 cites W2511909276 @default.
• W2956251012 cites W2559466477 @default.
• W2956251012 cites W2559859863 @default.
• W2956251012 cites W2572536948 @default.
• W2956251012 cites W2582520602 @default.
• W2956251012 cites W2602459412 @default.
• W2956251012 cites W2621354735 @default.
• W2956251012 cites W2741937797 @default.
• W2956251012 cites W2762001107 @default.
• W2956251012 cites W2772091186 @default.
• W2956251012 cites W2789710274 @default.
• W2956251012 cites W2790722904 @default.
• W2956251012 cites W2792450944 @default.
• W2956251012 cites W2797174336 @default.
• W2956251012 cites W2803750243 @default.
• W2956251012 cites W2805874297 @default.
• W2956251012 cites W2805963376 @default.
• W2956251012 cites W2806382960 @default.
• W2956251012 cites W2809065506 @default.
• W2956251012 cites W2810143528 @default.
• W2956251012 cites W2845591014 @default.
• W2956251012 cites W2883198394 @default.
• W2956251012 cites W2886281009 @default.
• W2956251012 cites W2893251498 @default.
• W2956251012 cites W2894299651 @default.
• W2956251012 cites W2894989282 @default.
• W2956251012 cites W2896699588 @default.
• W2956251012 cites W2902964933 @default.
• W2956251012 cites W2944259224 @default.
• W2956251012 cites W2950096631 @default.
• W2956251012 cites W2951368603 @default.
• W2956251012 cites W2951479823 @default.
• W2956251012 cites W2952558632 @default.
• W2956251012 cites W4233698560 @default.

• next