Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956285279> ?p ?o ?g. }
- W2956285279 abstract "By GWAS studies on celiac disease, gene expression was studied at the level of the whole intestinal mucosa, composed by two different compartments: epithelium and lamina propria. Our aim is to analyse the gene-expression and DNA methylation of candidate genes in each of these compartments. Epithelium was separated from lamina propria in biopsies of CeD patients and CTRs using magnetic beads. Gene-expression was analysed by RT-PC; methylation analysis required bisulfite conversion and NGS. Reverse modulation of gene-expression and methylation in the same cellular compartment was observed for the IL21 and SH2B3 genes in CeD patients relative to CTRs. Bioinformatics analysis highlighted the regulatory elements in the genomic region of SH2B3 that altered methylation levels. The cREL and TNFAIP3 genes showed methylation patterns that were significantly different between CeD patients and CTRs. In CeD, the genes linked to inflammatory processes are up-regulated, whereas the genes involved in the cell adhesion/integrity of the intestinal barrier are down-regulated. These findings suggest a correlation between gene-expression and methylation profile for the IL21 and SH2B3 genes. We identified a “gene-expression phenotype” of CeD and showed that the abnormal response to dietary antigens in CeD might be related not to abnormalities of gene structure but to the regulation of molecular pathways." @default.
- W2956285279 created "2019-07-23" @default.
- W2956285279 creator A5016193284 @default.
- W2956285279 creator A5022332197 @default.
- W2956285279 creator A5029061517 @default.
- W2956285279 creator A5039858303 @default.
- W2956285279 creator A5040688274 @default.
- W2956285279 creator A5062081088 @default.
- W2956285279 creator A5069159074 @default.
- W2956285279 creator A5070876800 @default.
- W2956285279 creator A5077006699 @default.
- W2956285279 creator A5081498719 @default.
- W2956285279 creator A5085536761 @default.
- W2956285279 date "2019-07-10" @default.
- W2956285279 modified "2023-10-15" @default.
- W2956285279 title "Combined Analysis of Methylation and Gene Expression Profiles in Separate Compartments of Small Bowel Mucosa Identified Celiac Disease Patients’ Signatures" @default.
- W2956285279 cites W1827058778 @default.
- W2956285279 cites W1908810890 @default.
- W2956285279 cites W1968901524 @default.
- W2956285279 cites W1974619577 @default.
- W2956285279 cites W1982855232 @default.
- W2956285279 cites W1983255429 @default.
- W2956285279 cites W1986077595 @default.
- W2956285279 cites W1991443138 @default.
- W2956285279 cites W1999863733 @default.
- W2956285279 cites W2009178411 @default.
- W2956285279 cites W2045266866 @default.
- W2956285279 cites W2065427932 @default.
- W2956285279 cites W2074050058 @default.
- W2956285279 cites W2077612013 @default.
- W2956285279 cites W2078752430 @default.
- W2956285279 cites W2080062510 @default.
- W2956285279 cites W2094351112 @default.
- W2956285279 cites W2095222091 @default.
- W2956285279 cites W2112409097 @default.
- W2956285279 cites W2125328419 @default.
- W2956285279 cites W2131829991 @default.
- W2956285279 cites W2132012375 @default.
- W2956285279 cites W2150234883 @default.
- W2956285279 cites W2164504476 @default.
- W2956285279 cites W2165412794 @default.
- W2956285279 cites W2169053321 @default.
- W2956285279 cites W2181795237 @default.
- W2956285279 cites W2217896533 @default.
- W2956285279 cites W2576474441 @default.
- W2956285279 doi "https://doi.org/10.1038/s41598-019-46468-2" @default.
- W2956285279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6620355" @default.
- W2956285279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31292504" @default.
- W2956285279 hasPublicationYear "2019" @default.
- W2956285279 type Work @default.
- W2956285279 sameAs 2956285279 @default.
- W2956285279 citedByCount "13" @default.
- W2956285279 countsByYear W29562852792019 @default.
- W2956285279 countsByYear W29562852792020 @default.
- W2956285279 countsByYear W29562852792021 @default.
- W2956285279 countsByYear W29562852792022 @default.
- W2956285279 countsByYear W29562852792023 @default.
- W2956285279 crossrefType "journal-article" @default.
- W2956285279 hasAuthorship W2956285279A5016193284 @default.
- W2956285279 hasAuthorship W2956285279A5022332197 @default.
- W2956285279 hasAuthorship W2956285279A5029061517 @default.
- W2956285279 hasAuthorship W2956285279A5039858303 @default.
- W2956285279 hasAuthorship W2956285279A5040688274 @default.
- W2956285279 hasAuthorship W2956285279A5062081088 @default.
- W2956285279 hasAuthorship W2956285279A5069159074 @default.
- W2956285279 hasAuthorship W2956285279A5070876800 @default.
- W2956285279 hasAuthorship W2956285279A5077006699 @default.
- W2956285279 hasAuthorship W2956285279A5081498719 @default.
- W2956285279 hasAuthorship W2956285279A5085536761 @default.
- W2956285279 hasBestOaLocation W29562852791 @default.
- W2956285279 hasConcept C104317684 @default.
- W2956285279 hasConcept C126322002 @default.
- W2956285279 hasConcept C142724271 @default.
- W2956285279 hasConcept C150194340 @default.
- W2956285279 hasConcept C190727270 @default.
- W2956285279 hasConcept C2779134260 @default.
- W2956285279 hasConcept C3019368612 @default.
- W2956285279 hasConcept C33288867 @default.
- W2956285279 hasConcept C54355233 @default.
- W2956285279 hasConcept C71924100 @default.
- W2956285279 hasConcept C86803240 @default.
- W2956285279 hasConceptScore W2956285279C104317684 @default.
- W2956285279 hasConceptScore W2956285279C126322002 @default.
- W2956285279 hasConceptScore W2956285279C142724271 @default.
- W2956285279 hasConceptScore W2956285279C150194340 @default.
- W2956285279 hasConceptScore W2956285279C190727270 @default.
- W2956285279 hasConceptScore W2956285279C2779134260 @default.
- W2956285279 hasConceptScore W2956285279C3019368612 @default.
- W2956285279 hasConceptScore W2956285279C33288867 @default.
- W2956285279 hasConceptScore W2956285279C54355233 @default.
- W2956285279 hasConceptScore W2956285279C71924100 @default.
- W2956285279 hasConceptScore W2956285279C86803240 @default.
- W2956285279 hasFunder F4320322218 @default.
- W2956285279 hasIssue "1" @default.
- W2956285279 hasLocation W29562852791 @default.
- W2956285279 hasLocation W29562852792 @default.
- W2956285279 hasLocation W29562852793 @default.
- W2956285279 hasLocation W29562852794 @default.
- W2956285279 hasLocation W29562852795 @default.
- W2956285279 hasOpenAccess W2956285279 @default.