FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956298719> ?p ?o ?g. }

• W2956298719 abstract "Abstract Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low immunoreactivity for cytokeratin and desmosome markers. Instead, they were detected by Calretinin (Calbindin-2) and Synaptic vesicle glycoprotein 2 (SV2) antibodies, indicating a calcium-regulated neurosecretory activity. Consistently, electron microscopy revealed abundant secretory organelles in desmosome-negative cells in the fin epidermis. Based on the markers, 5-HT, Calretinin and SV2, we referred to these cells as HCS-cells. We found that HCS-cells were spread throughout the entire caudal fin at an average density of 140 cells per mm 2 on each fin surface. These cells were strongly enriched at ray bifurcations in wild type fins, as well as in elongated fins of another longfin mutant fish. To determine whether hydrodynamics play a role in the distribution of HCS-cells, we used an interdisciplinary approach and performed kinematic analysis. Measurements of particle velocity with a fin model revealed differences in fluid velocities between bifurcated rods and adjacent non-bifurcated regions. Therefore the accumulation of HCS-cells near bone bifurcations may be a biological adaptation for sensing of water parameters. The significance of this HCS-cell pattern is reinforced by the fact, that it is reestablished in the regenerated fin after amputation. Regeneration of HCS-cells was not impaired by the chemical inhibition of serotonin synthesis, suggesting that this neurotransmitter is not essential for the restorative process. In conclusion, our study identified a specific population of solitary paraneurons in the zebrafish fin, whose distribution correlates with fluid dynamics." @default.
• W2956298719 created "2019-07-23" @default.
• W2956298719 creator A5009959790 @default.
• W2956298719 creator A5057573249 @default.
• W2956298719 creator A5062544738 @default.
• W2956298719 creator A5063626140 @default.
• W2956298719 creator A5072985874 @default.
• W2956298719 creator A5082025508 @default.
• W2956298719 date "2019-07-10" @default.
• W2956298719 modified "2023-09-24" @default.
• W2956298719 title "Distribution and restoration of serotonin-immunoreactive paraneuronal cells during caudal fin regeneration in zebrafish" @default.
• W2956298719 cites W1927139478 @default.
• W2956298719 cites W1965172427 @default.
• W2956298719 cites W1971803560 @default.
• W2956298719 cites W1971804121 @default.
• W2956298719 cites W1972360672 @default.
• W2956298719 cites W1973964873 @default.
• W2956298719 cites W1977690514 @default.
• W2956298719 cites W1978529094 @default.
• W2956298719 cites W1980494818 @default.
• W2956298719 cites W1982535174 @default.
• W2956298719 cites W1985538729 @default.
• W2956298719 cites W1985707949 @default.
• W2956298719 cites W1987235037 @default.
• W2956298719 cites W1989661955 @default.
• W2956298719 cites W1997615442 @default.
• W2956298719 cites W1997668305 @default.
• W2956298719 cites W1998531953 @default.
• W2956298719 cites W2006732982 @default.
• W2956298719 cites W2007986907 @default.
• W2956298719 cites W2014001473 @default.
• W2956298719 cites W2024203831 @default.
• W2956298719 cites W2025271354 @default.
• W2956298719 cites W2034656159 @default.
• W2956298719 cites W2037795975 @default.
• W2956298719 cites W2038463008 @default.
• W2956298719 cites W2039829206 @default.
• W2956298719 cites W2040418481 @default.
• W2956298719 cites W2044613056 @default.
• W2956298719 cites W2046725266 @default.
• W2956298719 cites W2049842274 @default.
• W2956298719 cites W2052495746 @default.
• W2956298719 cites W2052498348 @default.
• W2956298719 cites W2061468450 @default.
• W2956298719 cites W2064815668 @default.
• W2956298719 cites W2067625723 @default.
• W2956298719 cites W2070922640 @default.
• W2956298719 cites W2082876349 @default.
• W2956298719 cites W2083404673 @default.
• W2956298719 cites W2084654375 @default.
• W2956298719 cites W2090783065 @default.
• W2956298719 cites W2095498253 @default.
• W2956298719 cites W2109786161 @default.
• W2956298719 cites W2121612177 @default.
• W2956298719 cites W2122196253 @default.
• W2956298719 cites W2135190897 @default.
• W2956298719 cites W2147639568 @default.
• W2956298719 cites W2149186578 @default.
• W2956298719 cites W2150044044 @default.
• W2956298719 cites W2154825448 @default.
• W2956298719 cites W2156174448 @default.
• W2956298719 cites W2160260273 @default.
• W2956298719 cites W2235801130 @default.
• W2956298719 cites W2292556059 @default.
• W2956298719 cites W2317162308 @default.
• W2956298719 cites W2344942066 @default.
• W2956298719 cites W2387227493 @default.
• W2956298719 cites W2402517247 @default.
• W2956298719 cites W2413520294 @default.
• W2956298719 cites W2481858586 @default.
• W2956298719 cites W2485465902 @default.
• W2956298719 cites W2561988083 @default.
• W2956298719 cites W2592877185 @default.
• W2956298719 cites W2607239883 @default.
• W2956298719 cites W2620061333 @default.
• W2956298719 cites W2742020438 @default.
• W2956298719 cites W2745732937 @default.
• W2956298719 cites W2770937351 @default.
• W2956298719 cites W2775768612 @default.
• W2956298719 cites W2791248489 @default.
• W2956298719 cites W2886887771 @default.
• W2956298719 cites W4232058283 @default.
• W2956298719 cites W4235788351 @default.
• W2956298719 cites W4249279959 @default.
• W2956298719 cites W4302406231 @default.
• W2956298719 cites W45393816 @default.
• W2956298719 doi "https://doi.org/10.1101/698019" @default.
• W2956298719 hasPublicationYear "2019" @default.
• W2956298719 type Work @default.
• W2956298719 sameAs 2956298719 @default.
• W2956298719 citedByCount "0" @default.
• W2956298719 crossrefType "posted-content" @default.
• W2956298719 hasAuthorship W2956298719A5009959790 @default.
• W2956298719 hasAuthorship W2956298719A5057573249 @default.
• W2956298719 hasAuthorship W2956298719A5062544738 @default.
• W2956298719 hasAuthorship W2956298719A5063626140 @default.
• W2956298719 hasAuthorship W2956298719A5072985874 @default.
• W2956298719 hasAuthorship W2956298719A5082025508 @default.
• W2956298719 hasBestOaLocation W29562987191 @default.
• W2956298719 hasConcept C104317684 @default.

• next