Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956329092> ?p ?o ?g. }
- W2956329092 abstract "Chimeric antigen receptor (CAR)-modified T cell therapy is a rapidly emerging immunotherapeutic approach that is revolutionizing cancer treatment. The impressive clinical results obtained with CAR-T cell therapy in patients with acute lymphoblastic leukemia and lymphoma have fueled the development of CAR-T cells targeting other malignancies, including multiple myeloma (MM). The field of CAR-T cell therapy for MM is still in its infancy, but remains promising. To date, most studies have been performed with B cell maturation antigen (BCMA)-targeted CARs, for which high response rates have been obtained in early-phase clinical trials. However, responses are usually temporary, and relapses have frequently been observed. One of the major reasons for relapse is the loss or downregulation of BCMA expression following CAR-T therapy. This has fostered a search for alternative target antigens that are expressed on the MM cell surface. In this review, we provide an overview of myeloma target antigens other than BCMA that are currently being evaluated in preclinical and clinical studies." @default.
- W2956329092 created "2019-07-23" @default.
- W2956329092 creator A5001598297 @default.
- W2956329092 creator A5010168843 @default.
- W2956329092 creator A5017531416 @default.
- W2956329092 creator A5026607508 @default.
- W2956329092 creator A5027179416 @default.
- W2956329092 creator A5036256303 @default.
- W2956329092 creator A5043982532 @default.
- W2956329092 creator A5054443215 @default.
- W2956329092 creator A5086410678 @default.
- W2956329092 creator A5089769735 @default.
- W2956329092 date "2019-07-16" @default.
- W2956329092 modified "2023-10-18" @default.
- W2956329092 title "Chimeric Antigen Receptor-Modified T Cell Therapy in Multiple Myeloma: Beyond B Cell Maturation Antigen" @default.
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