Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956337922> ?p ?o ?g. }
- W2956337922 endingPage "104284" @default.
- W2956337922 startingPage "104284" @default.
- W2956337922 abstract "Leiomyosarcomas are rare, aggressive tumors, which exhibit a poor prognosis regardless of stage. Pre-operative diagnosis can be difficult as leiomyosarcoma can mimic features of the more common, benign uterine leiomyoma. The goal of this study was to identify specific molecular markers to discriminate between uterine leiomyosarcomas and leiomyomas to facilitate timely, accurate diagnosis and treatment. Gene expression profiles of three leiomyosarcomas, leiomyomas, and normal myometrial tissue samples were analyzed using the Affymetrix Human Gene 1.0 ST Array. GC-robust multiarray average calculation and ANOVA statistical testing were used to identify differentially expressed genes. Sixty genes, with functional roles in tumor progression or suppression, exhibited divergent expression profiles in leiomyosarcomas and leiomyomas, compared to normal myometrium. Differential RNA and protein levels of seven genes, with the most discriminatory expression patterns, were confirmed by RTPCR and immunohistochemistry in an additional 10 leiomyosarcoma and 20 leiomyoma independent samples. CHI3L1, MELK, PRC1, TOP2A, and TPX2 were overexpressed in leiomyosarcomas, while HPGD and TES were overexpressed in leiomyomas. Distinguishing leiomyosarcomas from leiomyomas represents a diagnostic challenge, particularly in the context of minimally invasive surgery. The unique gene expression signatures identified in this study may accurately differentiate between these tumor types at the earliest stage and provides potential prognostic factors and novel therapeutic targets for the treatment of leiomyosarcoma." @default.
- W2956337922 created "2019-07-23" @default.
- W2956337922 creator A5007353936 @default.
- W2956337922 creator A5009699433 @default.
- W2956337922 creator A5016072487 @default.
- W2956337922 creator A5017784878 @default.
- W2956337922 creator A5035109058 @default.
- W2956337922 creator A5049500124 @default.
- W2956337922 creator A5050160573 @default.
- W2956337922 date "2019-10-01" @default.
- W2956337922 modified "2023-10-14" @default.
- W2956337922 title "Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma" @default.
- W2956337922 cites W1502045029 @default.
- W2956337922 cites W1647740149 @default.
- W2956337922 cites W1965381596 @default.
- W2956337922 cites W1969018878 @default.
- W2956337922 cites W1984902398 @default.
- W2956337922 cites W1992425156 @default.
- W2956337922 cites W1996392388 @default.
- W2956337922 cites W2001242241 @default.
- W2956337922 cites W2001564888 @default.
- W2956337922 cites W2019293853 @default.
- W2956337922 cites W2056257742 @default.
- W2956337922 cites W2060895401 @default.
- W2956337922 cites W2062598017 @default.
- W2956337922 cites W2067560982 @default.
- W2956337922 cites W2069152026 @default.
- W2956337922 cites W2071123235 @default.
- W2956337922 cites W2088056659 @default.
- W2956337922 cites W2091789196 @default.
- W2956337922 cites W2094402002 @default.
- W2956337922 cites W2103133009 @default.
- W2956337922 cites W2116146003 @default.
- W2956337922 cites W2118471037 @default.
- W2956337922 cites W2119030486 @default.
- W2956337922 cites W2122935349 @default.
- W2956337922 cites W2128875155 @default.
- W2956337922 cites W2129429170 @default.
- W2956337922 cites W2137546499 @default.
- W2956337922 cites W2140028786 @default.
- W2956337922 cites W2155597252 @default.
- W2956337922 cites W2156040520 @default.
- W2956337922 cites W2161216558 @default.
- W2956337922 cites W2167649358 @default.
- W2956337922 cites W2588395027 @default.
- W2956337922 doi "https://doi.org/10.1016/j.yexmp.2019.104284" @default.
- W2956337922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31301306" @default.
- W2956337922 hasPublicationYear "2019" @default.
- W2956337922 type Work @default.
- W2956337922 sameAs 2956337922 @default.
- W2956337922 citedByCount "9" @default.
- W2956337922 countsByYear W29563379222021 @default.
- W2956337922 countsByYear W29563379222022 @default.
- W2956337922 countsByYear W29563379222023 @default.
- W2956337922 crossrefType "journal-article" @default.
- W2956337922 hasAuthorship W2956337922A5007353936 @default.
- W2956337922 hasAuthorship W2956337922A5009699433 @default.
- W2956337922 hasAuthorship W2956337922A5016072487 @default.
- W2956337922 hasAuthorship W2956337922A5017784878 @default.
- W2956337922 hasAuthorship W2956337922A5035109058 @default.
- W2956337922 hasAuthorship W2956337922A5049500124 @default.
- W2956337922 hasAuthorship W2956337922A5050160573 @default.
- W2956337922 hasConcept C104317684 @default.
- W2956337922 hasConcept C142724271 @default.
- W2956337922 hasConcept C150194340 @default.
- W2956337922 hasConcept C18431079 @default.
- W2956337922 hasConcept C203014093 @default.
- W2956337922 hasConcept C204232928 @default.
- W2956337922 hasConcept C2777532014 @default.
- W2956337922 hasConcept C2777795800 @default.
- W2956337922 hasConcept C2778164554 @default.
- W2956337922 hasConcept C2779066055 @default.
- W2956337922 hasConcept C2911016000 @default.
- W2956337922 hasConcept C3017725331 @default.
- W2956337922 hasConcept C502942594 @default.
- W2956337922 hasConcept C54355233 @default.
- W2956337922 hasConcept C71924100 @default.
- W2956337922 hasConcept C86803240 @default.
- W2956337922 hasConceptScore W2956337922C104317684 @default.
- W2956337922 hasConceptScore W2956337922C142724271 @default.
- W2956337922 hasConceptScore W2956337922C150194340 @default.
- W2956337922 hasConceptScore W2956337922C18431079 @default.
- W2956337922 hasConceptScore W2956337922C203014093 @default.
- W2956337922 hasConceptScore W2956337922C204232928 @default.
- W2956337922 hasConceptScore W2956337922C2777532014 @default.
- W2956337922 hasConceptScore W2956337922C2777795800 @default.
- W2956337922 hasConceptScore W2956337922C2778164554 @default.
- W2956337922 hasConceptScore W2956337922C2779066055 @default.
- W2956337922 hasConceptScore W2956337922C2911016000 @default.
- W2956337922 hasConceptScore W2956337922C3017725331 @default.
- W2956337922 hasConceptScore W2956337922C502942594 @default.
- W2956337922 hasConceptScore W2956337922C54355233 @default.
- W2956337922 hasConceptScore W2956337922C71924100 @default.
- W2956337922 hasConceptScore W2956337922C86803240 @default.
- W2956337922 hasLocation W29563379221 @default.
- W2956337922 hasLocation W29563379222 @default.
- W2956337922 hasOpenAccess W2956337922 @default.
- W2956337922 hasPrimaryLocation W29563379221 @default.