FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956338066> ?p ?o ?g. }

• W2956338066 endingPage "372" @default.
• W2956338066 startingPage "366" @default.
• W2956338066 abstract "The aim of this study was to investigate the role of matrix metallopeptidase 12 (MMP-12) in the development of hepatocellular carcinoma (HCC). Materials and Methods: A total of 343 HCC patients were retrospectively analyzed. MMP-12 expression was detected by immunohistochemical staining and the correlation between MMP-12 expression and clinical features was analyzed. Serum interleukin-6 (IL-6) and IL-10 levels were detected by an enzyme-linked immunosorbent assay (ELISA). Survival analysis was performed using the Kaplan-Meier method and PD-L1 expression in T cells was detected by flow cytometry. Results: MMP-12 expression in HCC tissues showed no correlation with age, gender, viral infection, cirrhosis, Child-Pugh score, alpha-fetoprotein levels, or Barcelona-Clinic Liver Cancer stage. However, higher levels of MMP-12 expression were correlated with increased tumor size, poorer tumor cell differentiation, higher TNM stage, and poorer prognosis. Moreover, MMP-12 expression was positively correlated with PD-L1 expression. Further analysis indicated that the regulation of PD-L1 expression by MMP-12 may occur through the IL-6-signaling pathway. Conclusions: Higher levels of MMP-12 expression indicated a poorer prognosis. PD-L1 expression was positively correlated with MMP-12 expression, indicating that MMP-12 may promote the development of HCC through the up-regulation of PD-L1." @default.
• W2956338066 created "2019-07-23" @default.
• W2956338066 creator A5008750923 @default.
• W2956338066 creator A5012270936 @default.
• W2956338066 creator A5025643196 @default.
• W2956338066 creator A5031989456 @default.
• W2956338066 creator A5037522176 @default.
• W2956338066 creator A5048327095 @default.
• W2956338066 creator A5065715690 @default.
• W2956338066 creator A5069826909 @default.
• W2956338066 creator A5083753218 @default.
• W2956338066 creator A5084010516 @default.
• W2956338066 date "2019-07-15" @default.
• W2956338066 modified "2023-09-28" @default.
• W2956338066 title "Role of Matrix Metallopeptidase 12 in the Development of Hepatocellular Carcinoma" @default.
• W2956338066 cites W1545521314 @default.
• W2956338066 cites W1976789167 @default.
• W2956338066 cites W1978857579 @default.
• W2956338066 cites W1983102762 @default.
• W2956338066 cites W1983109993 @default.
• W2956338066 cites W1991235944 @default.
• W2956338066 cites W1999075493 @default.
• W2956338066 cites W2006832371 @default.
• W2956338066 cites W2020863153 @default.
• W2956338066 cites W2022143863 @default.
• W2956338066 cites W2029086221 @default.
• W2956338066 cites W2036489403 @default.
• W2956338066 cites W2046257690 @default.
• W2956338066 cites W2052968488 @default.
• W2956338066 cites W2063618524 @default.
• W2956338066 cites W2063699934 @default.
• W2956338066 cites W2077968480 @default.
• W2956338066 cites W2084941167 @default.
• W2956338066 cites W2088629624 @default.
• W2956338066 cites W2125068253 @default.
• W2956338066 cites W2130207101 @default.
• W2956338066 cites W2136313650 @default.
• W2956338066 cites W2158585862 @default.
• W2956338066 cites W2162667703 @default.
• W2956338066 cites W2166718558 @default.
• W2956338066 cites W2272984102 @default.
• W2956338066 cites W2283766940 @default.
• W2956338066 cites W2505096250 @default.
• W2956338066 cites W2592159070 @default.
• W2956338066 cites W2752160414 @default.
• W2956338066 cites W2757201757 @default.
• W2956338066 cites W2791793584 @default.
• W2956338066 cites W2796960432 @default.
• W2956338066 cites W2890493276 @default.
• W2956338066 cites W4230195560 @default.
• W2956338066 cites W4250908540 @default.
• W2956338066 doi "https://doi.org/10.1080/08941939.2019.1637975" @default.
• W2956338066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31304819" @default.
• W2956338066 hasPublicationYear "2019" @default.
• W2956338066 type Work @default.
• W2956338066 sameAs 2956338066 @default.
• W2956338066 citedByCount "5" @default.
• W2956338066 countsByYear W29563380662020 @default.
• W2956338066 countsByYear W29563380662021 @default.
• W2956338066 countsByYear W29563380662022 @default.
• W2956338066 countsByYear W29563380662023 @default.
• W2956338066 crossrefType "journal-article" @default.
• W2956338066 hasAuthorship W2956338066A5008750923 @default.
• W2956338066 hasAuthorship W2956338066A5012270936 @default.
• W2956338066 hasAuthorship W2956338066A5025643196 @default.
• W2956338066 hasAuthorship W2956338066A5031989456 @default.
• W2956338066 hasAuthorship W2956338066A5037522176 @default.
• W2956338066 hasAuthorship W2956338066A5048327095 @default.
• W2956338066 hasAuthorship W2956338066A5065715690 @default.
• W2956338066 hasAuthorship W2956338066A5069826909 @default.
• W2956338066 hasAuthorship W2956338066A5083753218 @default.
• W2956338066 hasAuthorship W2956338066A5084010516 @default.
• W2956338066 hasConcept C109523444 @default.
• W2956338066 hasConcept C126322002 @default.
• W2956338066 hasConcept C142724271 @default.
• W2956338066 hasConcept C143998085 @default.
• W2956338066 hasConcept C146357865 @default.
• W2956338066 hasConcept C151730666 @default.
• W2956338066 hasConcept C203014093 @default.
• W2956338066 hasConcept C204232928 @default.
• W2956338066 hasConcept C2776231280 @default.
• W2956338066 hasConcept C2777214474 @default.
• W2956338066 hasConcept C2778019345 @default.
• W2956338066 hasConcept C502942594 @default.
• W2956338066 hasConcept C553184892 @default.
• W2956338066 hasConcept C71924100 @default.
• W2956338066 hasConcept C86803240 @default.
• W2956338066 hasConceptScore W2956338066C109523444 @default.
• W2956338066 hasConceptScore W2956338066C126322002 @default.
• W2956338066 hasConceptScore W2956338066C142724271 @default.
• W2956338066 hasConceptScore W2956338066C143998085 @default.
• W2956338066 hasConceptScore W2956338066C146357865 @default.
• W2956338066 hasConceptScore W2956338066C151730666 @default.
• W2956338066 hasConceptScore W2956338066C203014093 @default.
• W2956338066 hasConceptScore W2956338066C204232928 @default.
• W2956338066 hasConceptScore W2956338066C2776231280 @default.
• W2956338066 hasConceptScore W2956338066C2777214474 @default.
• W2956338066 hasConceptScore W2956338066C2778019345 @default.

• next