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- W2956338497 endingPage "180" @default.
- W2956338497 startingPage "169" @default.
- W2956338497 abstract "The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a specialized compartment with a unique proteome. In order to ensure compartmental homeostasis, INM-associated degradation (INMAD) is required for both protein quality control and regulated proteolysis of INM proteins. INMAD shares similarities with ER-associated degradation (ERAD). The mechanism of ERAD is well characterized, whereas the INMAD pathway requires further definition. Here we review the three different branches of INMAD, mediated by their respective E3 ubiquitin ligases: Doa10, Asi1-3, and APC/C. We clarify the distinction between ERAD and INMAD, their substrate recognition signals, and the subsequent processing by their respective degradation machineries. We also discuss the significance of cell-cycle and developmental regulation of protein clearance at the INM, and its relationship to human disease." @default.
- W2956338497 created "2019-07-23" @default.
- W2956338497 creator A5054791997 @default.
- W2956338497 creator A5065681510 @default.
- W2956338497 date "2019-01-01" @default.
- W2956338497 modified "2023-10-12" @default.
- W2956338497 title "Regulation of inner nuclear membrane associated protein degradation" @default.
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