FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956353952> ?p ?o ?g. }

• W2956353952 endingPage "105573" @default.
• W2956353952 startingPage "105573" @default.
• W2956353952 abstract "It has been clinically documented that maduramicin (Mad), a polyether ionophore antibiotic widely used in the control of coccidiosis in poultry worldwide, can elicit skeletal muscle degeneration, heart failure, and even death in animals and humans, if improperly used. Here, we show that Mad induced apoptosis dose-dependently, which was associated with impaired autophagic flux in skeletal myoblast (C2C12 and L6) cells. This is supported by the findings that Mad treatment resulted in increase of autophagosomes with a concomitant elevation of LC3-II and p62 in the cells. Also, Mad increased co-localization of mCherry and GFP tandem-tagged LC3 puncta in the cells, suggesting a blockage of autophagic flux. Furthermore, addition of chloroquine (CQ) strengthened the basic and Mad-enhanced LC3-II and p62 levels, autophagosome formation and cell apoptosis, whereas pretreatment with rapamycin alleviated the effects in the cells exposed to Mad. Moreover, we noticed that Mad treatment inactivated Akt dose-dependently. Inhibition of Akt with inhibitor X potentiated Mad-induced decrease in phosphorylated Akt, and increases in LC3-II and p62 levels, autophagosome formation and cell apoptosis, whereas ectopic expression of constitutively active Akt rendered resistance to these events. Collectively, these results indicate that Mad inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. Our findings suggest that manipulation of Akt activity to improve autophagic flux is a promising strategy against Mad-induced myotoxicity." @default.
• W2956353952 created "2019-07-23" @default.
• W2956353952 creator A5010488457 @default.
• W2956353952 creator A5012324763 @default.
• W2956353952 creator A5044367029 @default.
• W2956353952 creator A5053993994 @default.
• W2956353952 creator A5055484399 @default.
• W2956353952 creator A5056236904 @default.
• W2956353952 creator A5077189352 @default.
• W2956353952 creator A5083421941 @default.
• W2956353952 creator A5083492085 @default.
• W2956353952 creator A5090376184 @default.
• W2956353952 date "2019-09-01" @default.
• W2956353952 modified "2023-10-02" @default.
• W2956353952 title "Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells" @default.
• W2956353952 cites W1523693806 @default.
• W2956353952 cites W1599366903 @default.
• W2956353952 cites W166423020 @default.
• W2956353952 cites W1972373884 @default.
• W2956353952 cites W1977767269 @default.
• W2956353952 cites W1985226577 @default.
• W2956353952 cites W1987566410 @default.
• W2956353952 cites W1993458861 @default.
• W2956353952 cites W1994823455 @default.
• W2956353952 cites W2001926512 @default.
• W2956353952 cites W2002745100 @default.
• W2956353952 cites W2020683096 @default.
• W2956353952 cites W2025665129 @default.
• W2956353952 cites W2026834042 @default.
• W2956353952 cites W2027682732 @default.
• W2956353952 cites W2030766513 @default.
• W2956353952 cites W2030909767 @default.
• W2956353952 cites W2030948786 @default.
• W2956353952 cites W2039785561 @default.
• W2956353952 cites W2042197283 @default.
• W2956353952 cites W2042816185 @default.
• W2956353952 cites W2048030072 @default.
• W2956353952 cites W2048121649 @default.
• W2956353952 cites W2051062186 @default.
• W2956353952 cites W2054574976 @default.
• W2956353952 cites W2058770444 @default.
• W2956353952 cites W2059159442 @default.
• W2956353952 cites W2066030465 @default.
• W2956353952 cites W2067692987 @default.
• W2956353952 cites W2076128762 @default.
• W2956353952 cites W2081057817 @default.
• W2956353952 cites W2109034822 @default.
• W2956353952 cites W2113118283 @default.
• W2956353952 cites W2126638918 @default.
• W2956353952 cites W2127984419 @default.
• W2956353952 cites W2133256272 @default.
• W2956353952 cites W2135574023 @default.
• W2956353952 cites W2136703555 @default.
• W2956353952 cites W2148281700 @default.
• W2956353952 cites W2149306102 @default.
• W2956353952 cites W2151802152 @default.
• W2956353952 cites W2156251634 @default.
• W2956353952 cites W2181644149 @default.
• W2956353952 cites W2261777694 @default.
• W2956353952 cites W2516596640 @default.
• W2956353952 cites W2602035017 @default.
• W2956353952 cites W2743254891 @default.
• W2956353952 cites W2748433012 @default.
• W2956353952 cites W2766896348 @default.
• W2956353952 cites W2805653013 @default.
• W2956353952 cites W2888736362 @default.
• W2956353952 doi "https://doi.org/10.1016/j.biocel.2019.105573" @default.
• W2956353952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31325628" @default.
• W2956353952 hasPublicationYear "2019" @default.
• W2956353952 type Work @default.
• W2956353952 sameAs 2956353952 @default.
• W2956353952 citedByCount "3" @default.
• W2956353952 countsByYear W29563539522021 @default.
• W2956353952 countsByYear W29563539522023 @default.
• W2956353952 crossrefType "journal-article" @default.
• W2956353952 hasAuthorship W2956353952A5010488457 @default.
• W2956353952 hasAuthorship W2956353952A5012324763 @default.
• W2956353952 hasAuthorship W2956353952A5044367029 @default.
• W2956353952 hasAuthorship W2956353952A5053993994 @default.
• W2956353952 hasAuthorship W2956353952A5055484399 @default.
• W2956353952 hasAuthorship W2956353952A5056236904 @default.
• W2956353952 hasAuthorship W2956353952A5077189352 @default.
• W2956353952 hasAuthorship W2956353952A5083421941 @default.
• W2956353952 hasAuthorship W2956353952A5083492085 @default.
• W2956353952 hasAuthorship W2956353952A5090376184 @default.
• W2956353952 hasBestOaLocation W29563539522 @default.
• W2956353952 hasConcept C11960822 @default.
• W2956353952 hasConcept C134018914 @default.
• W2956353952 hasConcept C168296220 @default.
• W2956353952 hasConcept C185592680 @default.
• W2956353952 hasConcept C190283241 @default.
• W2956353952 hasConcept C203522944 @default.
• W2956353952 hasConcept C207200792 @default.
• W2956353952 hasConcept C2779959927 @default.
• W2956353952 hasConcept C31573885 @default.
• W2956353952 hasConcept C55493867 @default.
• W2956353952 hasConcept C62478195 @default.
• W2956353952 hasConcept C75217442 @default.

• next