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- W2956371126 endingPage "338" @default.
- W2956371126 startingPage "338" @default.
- W2956371126 abstract "The rapid advancement in medicine requires the search for new drugs, but also for new carrier systems for more efficient and targeted delivery of the bioactive molecules. Among the latter, polymeric nanocarriers have an increasingly growing potential for clinical applications due to their unique physical and chemical characteristics. In this regard, nanosystems based on hyaluronic acid (HA), a polysaccharide which is ubiquitous in the body, have attracted particular interest because of the biocompatibility, biodegradability and nonimmunogenic property provided by HA. Furthermore, the fact that hyaluronic acid can be recognized by cell surface receptors in tumor cells, makes it an ideal candidate for the targeted delivery of anticancer drugs. In this review, we compile a comprehensive overview of the different types of soft nanocarriers based on HA conjugated or complexed with another polymer: micelles, nanoparticles, nanogels and polymersomes. Emphasis is made on the properties of the polymers used as well as the synthetic approaches for obtaining the different HA-polymer systems. Fabrication, characterization and potential biomedical applications of the nanocarriers will also be described." @default.
- W2956371126 created "2019-07-23" @default.
- W2956371126 creator A5003370171 @default.
- W2956371126 creator A5069672592 @default.
- W2956371126 creator A5085726282 @default.
- W2956371126 date "2019-07-15" @default.
- W2956371126 modified "2023-10-14" @default.
- W2956371126 title "Design of Soft Nanocarriers Combining Hyaluronic Acid with Another Functional Polymer for Cancer Therapy and Other Biomedical Applications" @default.
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- W2956371126 doi "https://doi.org/10.3390/pharmaceutics11070338" @default.
- W2956371126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6681414" @default.
- W2956371126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31311150" @default.
- W2956371126 hasPublicationYear "2019" @default.
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