FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956392568> ?p ?o ?g. }

• W2956392568 endingPage "9776" @default.
• W2956392568 startingPage "9770" @default.
• W2956392568 abstract "Macrophage foam cell formation mediated by CD36 receptor dependent internalization of oxidized low-density lipoprotein (oxLDL) is an important hallmark of early atherosclerosis. Activation of CD36 and its binding to oxLDL are the key points in foam cell formation. Herein, we develop a site-specific luminescence resonance energy transfer (LRET) system for the simultaneous imaging of CD36 activity and CD36-oxLDL binding on the cell surface. The system utilizes CD36-antibody-modified, SiO2-coated upconversion luminescent nanoparticles (UCNPs) as an energy donor to target the plasma membranes of macrophages, and DiI-oxLDL (energy acceptor) binds to CD36 and passes through the membrane during macrophage foam cell formation. Upon excitation at 980 nm, the LRET signal can be obtained because of the short distance between DiI-oxLDL and the nanoprobe. Additionally, the very specific fluorescence can be used to visualize distinct features of CD36. The nanoprobe also exhibits high sensitivity, good stability, simplicity, and low cost for the accurate detection and evaluation of macrophage foam cell formation. Moreover, using this novel nanoprobe, we also investigate the mechanism by which reactive oxygen species (ROS) signaling enhances the binding of oxLDL to CD36. ROS, especially O2·-, alter endothelial permeability and facilitate CD36 clustering, ultimately promoting the entry and internalization of oxLDL. Because of these advantages, this nanoprobe may provide a versatile platform for monitoring the progression of atherogenesis and elucidating atherogenesis signaling at the cellular level." @default.
• W2956392568 created "2019-07-23" @default.
• W2956392568 creator A5009256057 @default.
• W2956392568 creator A5020329063 @default.
• W2956392568 creator A5034707336 @default.
• W2956392568 creator A5047728695 @default.
• W2956392568 creator A5056588387 @default.
• W2956392568 creator A5064408814 @default.
• W2956392568 creator A5090789682 @default.
• W2956392568 date "2019-07-10" @default.
• W2956392568 modified "2023-10-15" @default.
• W2956392568 title "Luminescence-Resonance-Energy-Transfer-Based Luminescence Nanoprobe for In Situ Imaging of CD36 Activation and CD36–oxLDL Binding in Atherogenesis" @default.
• W2956392568 cites W1559813904 @default.
• W2956392568 cites W1891770701 @default.
• W2956392568 cites W1900506567 @default.
• W2956392568 cites W1972989434 @default.
• W2956392568 cites W1977109672 @default.
• W2956392568 cites W2002812554 @default.
• W2956392568 cites W2008071863 @default.
• W2956392568 cites W2010986334 @default.
• W2956392568 cites W2029081881 @default.
• W2956392568 cites W2033896075 @default.
• W2956392568 cites W2045982598 @default.
• W2956392568 cites W2049764769 @default.
• W2956392568 cites W2051710738 @default.
• W2956392568 cites W2064760068 @default.
• W2956392568 cites W2086442058 @default.
• W2956392568 cites W2093979977 @default.
• W2956392568 cites W2094629035 @default.
• W2956392568 cites W2102343617 @default.
• W2956392568 cites W2105916176 @default.
• W2956392568 cites W2119887057 @default.
• W2956392568 cites W2119921496 @default.
• W2956392568 cites W2123799914 @default.
• W2956392568 cites W2168975002 @default.
• W2956392568 cites W2299098537 @default.
• W2956392568 cites W2479269165 @default.
• W2956392568 cites W2481843462 @default.
• W2956392568 cites W2621371007 @default.
• W2956392568 cites W2622769153 @default.
• W2956392568 cites W2806741586 @default.
• W2956392568 cites W4211210890 @default.
• W2956392568 doi "https://doi.org/10.1021/acs.analchem.9b01398" @default.
• W2956392568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31288519" @default.
• W2956392568 hasPublicationYear "2019" @default.
• W2956392568 type Work @default.
• W2956392568 sameAs 2956392568 @default.
• W2956392568 citedByCount "9" @default.
• W2956392568 countsByYear W29563925682019 @default.
• W2956392568 countsByYear W29563925682020 @default.
• W2956392568 countsByYear W29563925682022 @default.
• W2956392568 countsByYear W29563925682023 @default.
• W2956392568 crossrefType "journal-article" @default.
• W2956392568 hasAuthorship W2956392568A5009256057 @default.
• W2956392568 hasAuthorship W2956392568A5020329063 @default.
• W2956392568 hasAuthorship W2956392568A5034707336 @default.
• W2956392568 hasAuthorship W2956392568A5047728695 @default.
• W2956392568 hasAuthorship W2956392568A5056588387 @default.
• W2956392568 hasAuthorship W2956392568A5064408814 @default.
• W2956392568 hasAuthorship W2956392568A5090789682 @default.
• W2956392568 hasConcept C121332964 @default.
• W2956392568 hasConcept C12554922 @default.
• W2956392568 hasConcept C139770010 @default.
• W2956392568 hasConcept C1491633281 @default.
• W2956392568 hasConcept C155672457 @default.
• W2956392568 hasConcept C16387964 @default.
• W2956392568 hasConcept C170493617 @default.
• W2956392568 hasConcept C171250308 @default.
• W2956392568 hasConcept C185592680 @default.
• W2956392568 hasConcept C192562407 @default.
• W2956392568 hasConcept C202751555 @default.
• W2956392568 hasConcept C2777895019 @default.
• W2956392568 hasConcept C2778106830 @default.
• W2956392568 hasConcept C2779244956 @default.
• W2956392568 hasConcept C2779828298 @default.
• W2956392568 hasConcept C55493867 @default.
• W2956392568 hasConcept C62520636 @default.
• W2956392568 hasConcept C86803240 @default.
• W2956392568 hasConcept C91881484 @default.
• W2956392568 hasConcept C96305047 @default.
• W2956392568 hasConceptScore W2956392568C121332964 @default.
• W2956392568 hasConceptScore W2956392568C12554922 @default.
• W2956392568 hasConceptScore W2956392568C139770010 @default.
• W2956392568 hasConceptScore W2956392568C1491633281 @default.
• W2956392568 hasConceptScore W2956392568C155672457 @default.
• W2956392568 hasConceptScore W2956392568C16387964 @default.
• W2956392568 hasConceptScore W2956392568C170493617 @default.
• W2956392568 hasConceptScore W2956392568C171250308 @default.
• W2956392568 hasConceptScore W2956392568C185592680 @default.
• W2956392568 hasConceptScore W2956392568C192562407 @default.
• W2956392568 hasConceptScore W2956392568C202751555 @default.
• W2956392568 hasConceptScore W2956392568C2777895019 @default.
• W2956392568 hasConceptScore W2956392568C2778106830 @default.
• W2956392568 hasConceptScore W2956392568C2779244956 @default.
• W2956392568 hasConceptScore W2956392568C2779828298 @default.
• W2956392568 hasConceptScore W2956392568C55493867 @default.
• W2956392568 hasConceptScore W2956392568C62520636 @default.
• W2956392568 hasConceptScore W2956392568C86803240 @default.

• next