FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956407574> ?p ?o ?g. }

• W2956407574 endingPage "538" @default.
• W2956407574 startingPage "526" @default.
• W2956407574 abstract "High levels of oxygen are usually used in ventilatory support and extracorporeal membrane oxygenation (ECMO) in the intensive care unit of hospitals. Hyperoxia may induce the production of reactive oxygen species (ROS) that can cause lung damage and even systemic injury. In this study, the NF-κB/luciferase transgenic mouse model with non-invasive real-time in vivo imaging was established to test the functions of lactoferrin (LF) in antioxidant and anti-inflammation. The NF-κB/luciferase transgenic mice were used to assess the effects of oral administration of LF on attenuation of the systemic inflammatory response and organ damage after 72 h of hyperoxia (FiO2 > 95 %) exposure via monitoring using an in vivo imaging system (IVIS). Using luciferase IVIS imaging, we found that the lungs and kidneys were the most evidently affected organs after hyperoxia treatment. The groups treated with low dose (150 mg/kg) or high dose (300 mg/kg) of LF had lower luciferase expression and less injury, with a dose-dependent effect on the lungs and kidneys. Moreover, ROS, mitogen-activated protein kinases (MAPK), and pro-inflammatory cytokine (TNF-α, IL-1ß, and IL-6) expression levels were all significantly decreased (P < 0.01), and the protein level of IκB was statistically increased (P < 0.01) after LF treatment. Our results suggest that hyperoxia can induce systemic inflammation, and the oral administration of LF as a natural antioxidant decreases the production of ROS, attenuates inflammation, and lessens kidney and lung injuries from hyperoxia via the use of live image monitoring of the response in NF-kB/luciferase transgenic mice." @default.
• W2956407574 created "2019-07-23" @default.
• W2956407574 creator A5009079630 @default.
• W2956407574 creator A5017441850 @default.
• W2956407574 creator A5031487364 @default.
• W2956407574 creator A5042076969 @default.
• W2956407574 creator A5050353025 @default.
• W2956407574 creator A5064309998 @default.
• W2956407574 creator A5067454188 @default.
• W2956407574 creator A5082324939 @default.
• W2956407574 creator A5083510599 @default.
• W2956407574 creator A5087489224 @default.
• W2956407574 date "2019-07-08" @default.
• W2956407574 modified "2023-10-18" @default.
• W2956407574 title "Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice" @default.
• W2956407574 cites W1488327245 @default.
• W2956407574 cites W1778104662 @default.
• W2956407574 cites W1956277079 @default.
• W2956407574 cites W1971233601 @default.
• W2956407574 cites W1971672619 @default.
• W2956407574 cites W1980744863 @default.
• W2956407574 cites W1987917099 @default.
• W2956407574 cites W1992955675 @default.
• W2956407574 cites W1997281650 @default.
• W2956407574 cites W2001734898 @default.
• W2956407574 cites W2004550650 @default.
• W2956407574 cites W2012627045 @default.
• W2956407574 cites W2029013092 @default.
• W2956407574 cites W2034750982 @default.
• W2956407574 cites W2042165226 @default.
• W2956407574 cites W2042206193 @default.
• W2956407574 cites W2045333336 @default.
• W2956407574 cites W2049648123 @default.
• W2956407574 cites W2055328242 @default.
• W2956407574 cites W2068357117 @default.
• W2956407574 cites W2074280330 @default.
• W2956407574 cites W2075506276 @default.
• W2956407574 cites W2092700494 @default.
• W2956407574 cites W2105095232 @default.
• W2956407574 cites W2111581806 @default.
• W2956407574 cites W2118056311 @default.
• W2956407574 cites W2120787511 @default.
• W2956407574 cites W2128960111 @default.
• W2956407574 cites W2133950339 @default.
• W2956407574 cites W2135099611 @default.
• W2956407574 cites W2138667236 @default.
• W2956407574 cites W2140677435 @default.
• W2956407574 cites W2152640738 @default.
• W2956407574 cites W2158283460 @default.
• W2956407574 cites W2158710625 @default.
• W2956407574 cites W2169725996 @default.
• W2956407574 cites W2301684175 @default.
• W2956407574 cites W2797127742 @default.
• W2956407574 cites W2799474346 @default.
• W2956407574 doi "https://doi.org/10.1007/s11307-019-01390-x" @default.
• W2956407574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31286353" @default.
• W2956407574 hasPublicationYear "2019" @default.
• W2956407574 type Work @default.
• W2956407574 sameAs 2956407574 @default.
• W2956407574 citedByCount "17" @default.
• W2956407574 countsByYear W29564075742019 @default.
• W2956407574 countsByYear W29564075742020 @default.
• W2956407574 countsByYear W29564075742021 @default.
• W2956407574 countsByYear W29564075742022 @default.
• W2956407574 countsByYear W29564075742023 @default.
• W2956407574 crossrefType "journal-article" @default.
• W2956407574 hasAuthorship W2956407574A5009079630 @default.
• W2956407574 hasAuthorship W2956407574A5017441850 @default.
• W2956407574 hasAuthorship W2956407574A5031487364 @default.
• W2956407574 hasAuthorship W2956407574A5042076969 @default.
• W2956407574 hasAuthorship W2956407574A5050353025 @default.
• W2956407574 hasAuthorship W2956407574A5064309998 @default.
• W2956407574 hasAuthorship W2956407574A5067454188 @default.
• W2956407574 hasAuthorship W2956407574A5082324939 @default.
• W2956407574 hasAuthorship W2956407574A5083510599 @default.
• W2956407574 hasAuthorship W2956407574A5087489224 @default.
• W2956407574 hasBestOaLocation W29564075741 @default.
• W2956407574 hasConcept C102230213 @default.
• W2956407574 hasConcept C104317684 @default.
• W2956407574 hasConcept C111335760 @default.
• W2956407574 hasConcept C126322002 @default.
• W2956407574 hasConcept C141035611 @default.
• W2956407574 hasConcept C150903083 @default.
• W2956407574 hasConcept C185592680 @default.
• W2956407574 hasConcept C203014093 @default.
• W2956407574 hasConcept C207001950 @default.
• W2956407574 hasConcept C25938499 @default.
• W2956407574 hasConcept C26291073 @default.
• W2956407574 hasConcept C2776252253 @default.
• W2956407574 hasConcept C2776914184 @default.
• W2956407574 hasConcept C2777714996 @default.
• W2956407574 hasConcept C2779170986 @default.
• W2956407574 hasConcept C2780091579 @default.
• W2956407574 hasConcept C2780672939 @default.
• W2956407574 hasConcept C48349386 @default.
• W2956407574 hasConcept C54009773 @default.
• W2956407574 hasConcept C55493867 @default.
• W2956407574 hasConcept C71924100 @default.

• next