FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956457414> ?p ?o ?g. }

• W2956457414 abstract "Abstract Mutational robustness quantifies the effect of random mutations on fitness. When mutational robustness is high, most mutations do not change fitness or have only a minor effect on it. From the point of view of fitness landscapes, robust genotypes form neutral networks of almost equal fitness. Using deterministic population models it has been shown that selection favors genotypes inside such networks, which results in increased mutational robustness. Here we demonstrate that this effect is massively enhanced by recombination. Our results are based on a detailed analysis of mesa-shaped fitness landscapes, where we derive precise expressions for the dependence of the robustness on the landscape parameters for recombining and non-recombining populations. In addition, we carry out numerical simulations on different types of random holey landscapes as well as on an empirical fitness landscape. We show that the mutational robustness of a genotype generally correlates with its recombination weight, a new measure that quantifies the likelihood for the genotype to arise from recombination. We argue that the favorable effect of recombination on mutational robustness is a highly universal feature that may have played an important role in the emergence and maintenance of mechanisms of genetic exchange. Author summary Two long-standing and seemingly unrelated puzzles in evolutionary biology concern the ubiquity of sexual reproduction and the robustness of organisms against genetic perturbations. Using a theoretical approach based on the concept of a fitness landscape, in this article we argue that the two phenomena may in fact be closely related. In our setting the hereditary information of an organism is encoded in its genotype, which determines it to be either viable or non-viable, and robustness is defined as the fraction of mutations that maintain viability. Previous work has demonstrated that the purging of non-viable genotypes from the population by natural selection leads to a moderate increase in robustness. Here we show that genetic recombination acting in combination with selection massively enhances this effect, an observation that is largely independent of how genotypes are connected by mutations. This suggests that the increase of robustness may be a major driver underlying the evolution of sexual recombination and other forms of genetic exchange throughout the living world." @default.
• W2956457414 created "2019-07-23" @default.
• W2956457414 creator A5011264094 @default.
• W2956457414 creator A5048273505 @default.
• W2956457414 creator A5090876964 @default.
• W2956457414 date "2019-02-20" @default.
• W2956457414 modified "2023-09-23" @default.
• W2956457414 title "Recombination and mutational robustness in neutral fitness landscapes" @default.
• W2956457414 cites W1911278511 @default.
• W2956457414 cites W1965747065 @default.
• W2956457414 cites W1970185413 @default.
• W2956457414 cites W1983153145 @default.
• W2956457414 cites W1986146966 @default.
• W2956457414 cites W1992400103 @default.
• W2956457414 cites W1995865334 @default.
• W2956457414 cites W1996458622 @default.
• W2956457414 cites W1998485402 @default.
• W2956457414 cites W2001914917 @default.
• W2956457414 cites W2004917708 @default.
• W2956457414 cites W2005990191 @default.
• W2956457414 cites W2006413392 @default.
• W2956457414 cites W2007737718 @default.
• W2956457414 cites W2009216260 @default.
• W2956457414 cites W2012457691 @default.
• W2956457414 cites W2014496483 @default.
• W2956457414 cites W2018041072 @default.
• W2956457414 cites W2020413272 @default.
• W2956457414 cites W2022518804 @default.
• W2956457414 cites W2024329220 @default.
• W2956457414 cites W2024655862 @default.
• W2956457414 cites W2032388273 @default.
• W2956457414 cites W2033142425 @default.
• W2956457414 cites W2033889634 @default.
• W2956457414 cites W2035998101 @default.
• W2956457414 cites W2040994641 @default.
• W2956457414 cites W2042733284 @default.
• W2956457414 cites W2045716211 @default.
• W2956457414 cites W2060247350 @default.
• W2956457414 cites W2060737229 @default.
• W2956457414 cites W2063028997 @default.
• W2956457414 cites W2066558992 @default.
• W2956457414 cites W2075121996 @default.
• W2956457414 cites W2083539954 @default.
• W2956457414 cites W2090725059 @default.
• W2956457414 cites W2104062863 @default.
• W2956457414 cites W2107897198 @default.
• W2956457414 cites W2111857816 @default.
• W2956457414 cites W2120705912 @default.
• W2956457414 cites W2121105996 @default.
• W2956457414 cites W2121942252 @default.
• W2956457414 cites W2126183065 @default.
• W2956457414 cites W2126643167 @default.
• W2956457414 cites W2130315111 @default.
• W2956457414 cites W2131754114 @default.
• W2956457414 cites W2132396121 @default.
• W2956457414 cites W2147834333 @default.
• W2956457414 cites W2151907070 @default.
• W2956457414 cites W2153567460 @default.
• W2956457414 cites W2155420018 @default.
• W2956457414 cites W2165327448 @default.
• W2956457414 cites W2165732320 @default.
• W2956457414 cites W2593075177 @default.
• W2956457414 cites W2790805631 @default.
• W2956457414 cites W2793222991 @default.
• W2956457414 cites W2806410943 @default.
• W2956457414 cites W2906942791 @default.
• W2956457414 cites W3098107147 @default.
• W2956457414 cites W3100783777 @default.
• W2956457414 cites W3103032586 @default.
• W2956457414 cites W3104195973 @default.
• W2956457414 cites W4206751817 @default.
• W2956457414 cites W4211017114 @default.
• W2956457414 cites W4229641056 @default.
• W2956457414 cites W4235618707 @default.
• W2956457414 cites W4251042002 @default.
• W2956457414 doi "https://doi.org/10.1101/556134" @default.
• W2956457414 hasPublicationYear "2019" @default.
• W2956457414 type Work @default.
• W2956457414 sameAs 2956457414 @default.
• W2956457414 citedByCount "0" @default.
• W2956457414 crossrefType "posted-content" @default.
• W2956457414 hasAuthorship W2956457414A5011264094 @default.
• W2956457414 hasAuthorship W2956457414A5048273505 @default.
• W2956457414 hasAuthorship W2956457414A5090876964 @default.
• W2956457414 hasBestOaLocation W29564574141 @default.
• W2956457414 hasConcept C104317684 @default.
• W2956457414 hasConcept C144024400 @default.
• W2956457414 hasConcept C149129301 @default.
• W2956457414 hasConcept C149923435 @default.
• W2956457414 hasConcept C154945302 @default.
• W2956457414 hasConcept C156695909 @default.
• W2956457414 hasConcept C198125213 @default.
• W2956457414 hasConcept C2908647359 @default.
• W2956457414 hasConcept C2910387474 @default.
• W2956457414 hasConcept C41008148 @default.
• W2956457414 hasConcept C50644808 @default.
• W2956457414 hasConcept C54355233 @default.
• W2956457414 hasConcept C63479239 @default.
• W2956457414 hasConcept C78458016 @default.
• W2956457414 hasConcept C86803240 @default.

• next