Matches in SemOpenAlex for { <https://semopenalex.org/work/W29565265> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W29565265 endingPage "80" @default.
- W29565265 startingPage "371" @default.
- W29565265 abstract "Lacrimal gland inflammation develops in a number of autoimmune mice, including the MRL/Mp-lpr/lpr (MRL/lpr), MRL/Mp(-)+/+ (MRL/+), and NZB x NZW F1 hybrid (NZB/W) strains. The authors studied the evolution of this process, MRL/lpr mice had inflammatory lesions at 4 weeks old. The lesions had enlarged by 2 months and were fully developed by 4 to 5 months of age. In MRL/+ mice, 4-week-old mice had no lesions, although some focal inflammation was detectable at 3 months old. Significant abnormalities were present at 6 months, and persisted and increased throughout life, with all mice having extensive lesions at 18 months or older. In NZB/W mice, the authors detected no lesions until 6 months of age, and these lesions were fully developed in 9 months. Immunocytochemical profiles, of the cell types infiltrating the lacrimal gland, showed differences not only between the strains, but also in each strain as inflammation progressed. All three types of mice had L3T4+ T cells as the major lymphocyte component, although MRL/+ had significantly more Lyt 2+ T cells than the other strains. NZB/W mice had significantly more B cells than the two MRL substrains. In both NZB/W and MRL/+ mice, there was a significant increase in the B cell population, and a decrease in the percentage of L3T4+ T cells. There was a significant decline in Lyt 2+ T suppressor/cytotoxic cells in both NZB/W and MRL/lpr mice. This last finding was consistent with the more rapid development of inflammation in these strains than in the MRL/+ mice, where Lyt 2+ T suppressor/cytotoxic cells persist. Together, these results indicate that the autoimmune response in murine models of Sjögren's syndrome is a dynamic, evolving process with strain-related changes in lymphocyte subsets." @default.
- W29565265 created "2016-06-24" @default.
- W29565265 creator A5024676752 @default.
- W29565265 creator A5029506986 @default.
- W29565265 creator A5082563606 @default.
- W29565265 date "1991-02-01" @default.
- W29565265 modified "2023-10-16" @default.
- W29565265 title "Murine models of Sjögren's syndrome. Evolution of the lacrimal gland inflammatory lesions." @default.
- W29565265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1993589" @default.
- W29565265 hasPublicationYear "1991" @default.
- W29565265 type Work @default.
- W29565265 sameAs 29565265 @default.
- W29565265 citedByCount "14" @default.
- W29565265 countsByYear W295652652014 @default.
- W29565265 countsByYear W295652652015 @default.
- W29565265 crossrefType "journal-article" @default.
- W29565265 hasAuthorship W29565265A5024676752 @default.
- W29565265 hasAuthorship W29565265A5029506986 @default.
- W29565265 hasAuthorship W29565265A5082563606 @default.
- W29565265 hasConcept C126322002 @default.
- W29565265 hasConcept C134018914 @default.
- W29565265 hasConcept C142724271 @default.
- W29565265 hasConcept C154317977 @default.
- W29565265 hasConcept C159654299 @default.
- W29565265 hasConcept C202751555 @default.
- W29565265 hasConcept C203014093 @default.
- W29565265 hasConcept C2776914184 @default.
- W29565265 hasConcept C2777928079 @default.
- W29565265 hasConcept C2779075594 @default.
- W29565265 hasConcept C2779298748 @default.
- W29565265 hasConcept C2780130043 @default.
- W29565265 hasConcept C2908647359 @default.
- W29565265 hasConcept C2992881475 @default.
- W29565265 hasConcept C54355233 @default.
- W29565265 hasConcept C71924100 @default.
- W29565265 hasConcept C86803240 @default.
- W29565265 hasConcept C8891405 @default.
- W29565265 hasConcept C99454951 @default.
- W29565265 hasConceptScore W29565265C126322002 @default.
- W29565265 hasConceptScore W29565265C134018914 @default.
- W29565265 hasConceptScore W29565265C142724271 @default.
- W29565265 hasConceptScore W29565265C154317977 @default.
- W29565265 hasConceptScore W29565265C159654299 @default.
- W29565265 hasConceptScore W29565265C202751555 @default.
- W29565265 hasConceptScore W29565265C203014093 @default.
- W29565265 hasConceptScore W29565265C2776914184 @default.
- W29565265 hasConceptScore W29565265C2777928079 @default.
- W29565265 hasConceptScore W29565265C2779075594 @default.
- W29565265 hasConceptScore W29565265C2779298748 @default.
- W29565265 hasConceptScore W29565265C2780130043 @default.
- W29565265 hasConceptScore W29565265C2908647359 @default.
- W29565265 hasConceptScore W29565265C2992881475 @default.
- W29565265 hasConceptScore W29565265C54355233 @default.
- W29565265 hasConceptScore W29565265C71924100 @default.
- W29565265 hasConceptScore W29565265C86803240 @default.
- W29565265 hasConceptScore W29565265C8891405 @default.
- W29565265 hasConceptScore W29565265C99454951 @default.
- W29565265 hasIssue "2" @default.
- W29565265 hasLocation W295652651 @default.
- W29565265 hasOpenAccess W29565265 @default.
- W29565265 hasPrimaryLocation W295652651 @default.
- W29565265 hasRelatedWork W180179560 @default.
- W29565265 hasRelatedWork W1999231041 @default.
- W29565265 hasRelatedWork W2054679907 @default.
- W29565265 hasRelatedWork W2109923158 @default.
- W29565265 hasRelatedWork W2125248743 @default.
- W29565265 hasRelatedWork W2164255384 @default.
- W29565265 hasRelatedWork W2409178111 @default.
- W29565265 hasRelatedWork W2415805459 @default.
- W29565265 hasRelatedWork W2418457029 @default.
- W29565265 hasRelatedWork W41650702 @default.
- W29565265 hasVolume "32" @default.
- W29565265 isParatext "false" @default.
- W29565265 isRetracted "false" @default.
- W29565265 magId "29565265" @default.
- W29565265 workType "article" @default.