Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956578430> ?p ?o ?g. }
- W2956578430 abstract "A compulsive phenotype characterizes several neuropsychiatric illnesses - including but not limited to - schizophrenia and obsessive compulsive disorder. Because of its perceived etiological heterogeneity, it is challenging to disentangle the specific neurophysiology that precipitates compulsive behaving. Using polydipsia (or non-regulatory water drinking), we describe candidate neural substrates of compulsivity. We further postulate that aberrant neuroplasticity within cortically projecting structures [i.e., the bed nucleus of the stria terminalis (BNST)] and circuits that encode homeostatic emotions (thirst, hunger, satiety, etc.) underlie compulsive drinking. By transducing an inaccurate signal that fails to represent true homeostatic state, cortical structures cannot select appropriate and adaptive actions. Additionally, augmented dopamine (DA) reactivity in striatal projections to and from the frontal cortex contribute to aberrant homeostatic signal propagation that ultimately biases cortex-dependent behavioral selection. Responding becomes rigid and corresponds with both erroneous, inflexible encoding in both bottom-up structures and in top-down pathways. How aberrant neuroplasticity in circuits that encode homeostatic emotion result in the genesis and maintenance of compulsive behaviors needs further investigation." @default.
- W2956578430 created "2019-07-23" @default.
- W2956578430 creator A5016049930 @default.
- W2956578430 creator A5021568220 @default.
- W2956578430 date "2019-08-01" @default.
- W2956578430 modified "2023-09-25" @default.
- W2956578430 title "The Bed Nucleus of the Stria Terminalis, Homeostatic Satiety, and Compulsions: What Can We Learn From Polydipsia?" @default.
- W2956578430 cites W114047989 @default.
- W2956578430 cites W1629485274 @default.
- W2956578430 cites W1635722505 @default.
- W2956578430 cites W1755010820 @default.
- W2956578430 cites W1798489567 @default.
- W2956578430 cites W1804793362 @default.
- W2956578430 cites W1811761275 @default.
- W2956578430 cites W1856679114 @default.
- W2956578430 cites W1893851251 @default.
- W2956578430 cites W1913981714 @default.
- W2956578430 cites W1924731384 @default.
- W2956578430 cites W1959140011 @default.
- W2956578430 cites W1963583370 @default.
- W2956578430 cites W1964356197 @default.
- W2956578430 cites W1965865206 @default.
- W2956578430 cites W1966054390 @default.
- W2956578430 cites W1967096421 @default.
- W2956578430 cites W1967786852 @default.
- W2956578430 cites W1968882153 @default.
- W2956578430 cites W1969246907 @default.
- W2956578430 cites W1970629024 @default.
- W2956578430 cites W1971994650 @default.
- W2956578430 cites W1972202495 @default.
- W2956578430 cites W1973438804 @default.
- W2956578430 cites W1974992197 @default.
- W2956578430 cites W1975401347 @default.
- W2956578430 cites W1976900728 @default.
- W2956578430 cites W1977741174 @default.
- W2956578430 cites W1979457008 @default.
- W2956578430 cites W1979785761 @default.
- W2956578430 cites W1979906070 @default.
- W2956578430 cites W1980505353 @default.
- W2956578430 cites W1980671117 @default.
- W2956578430 cites W1981232769 @default.
- W2956578430 cites W1981345490 @default.
- W2956578430 cites W1981739486 @default.
- W2956578430 cites W1982353651 @default.
- W2956578430 cites W1982603796 @default.
- W2956578430 cites W1983108871 @default.
- W2956578430 cites W1984469415 @default.
- W2956578430 cites W1986875569 @default.
- W2956578430 cites W1988149623 @default.
- W2956578430 cites W1988557269 @default.
- W2956578430 cites W1990449663 @default.
- W2956578430 cites W1992193354 @default.
- W2956578430 cites W1992977210 @default.
- W2956578430 cites W1993701449 @default.
- W2956578430 cites W1994758108 @default.
- W2956578430 cites W1994984635 @default.
- W2956578430 cites W1995600769 @default.
- W2956578430 cites W1996202073 @default.
- W2956578430 cites W1996327177 @default.
- W2956578430 cites W1996702046 @default.
- W2956578430 cites W2002379310 @default.
- W2956578430 cites W2003371757 @default.
- W2956578430 cites W2003921915 @default.
- W2956578430 cites W2003955639 @default.
- W2956578430 cites W2003956812 @default.
- W2956578430 cites W2006331049 @default.
- W2956578430 cites W2007465838 @default.
- W2956578430 cites W2008005549 @default.
- W2956578430 cites W2008280777 @default.
- W2956578430 cites W2008368085 @default.
- W2956578430 cites W2008503896 @default.
- W2956578430 cites W2009429333 @default.
- W2956578430 cites W2009450158 @default.
- W2956578430 cites W2009465903 @default.
- W2956578430 cites W2009617406 @default.
- W2956578430 cites W2009744426 @default.
- W2956578430 cites W2010643559 @default.
- W2956578430 cites W2011003407 @default.
- W2956578430 cites W2011408679 @default.
- W2956578430 cites W2012440798 @default.
- W2956578430 cites W2013580724 @default.
- W2956578430 cites W2013586816 @default.
- W2956578430 cites W2013812773 @default.
- W2956578430 cites W2014400587 @default.
- W2956578430 cites W2014956678 @default.
- W2956578430 cites W2015183704 @default.
- W2956578430 cites W2016117011 @default.
- W2956578430 cites W2016845716 @default.
- W2956578430 cites W2017343750 @default.
- W2956578430 cites W2017534455 @default.
- W2956578430 cites W2017822321 @default.
- W2956578430 cites W2017838119 @default.
- W2956578430 cites W2018235826 @default.
- W2956578430 cites W2018376764 @default.
- W2956578430 cites W2020521877 @default.
- W2956578430 cites W2020742791 @default.
- W2956578430 cites W2021489201 @default.
- W2956578430 cites W2022106712 @default.
- W2956578430 cites W2022335135 @default.
- W2956578430 cites W2023206850 @default.