FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956659207> ?p ?o ?g. }

• W2956659207 endingPage "87.e2" @default.
• W2956659207 startingPage "82" @default.
• W2956659207 abstract "Objective To evaluate the relationship between detection of DNA viruses, ferritin, and outcomes in children with severe sepsis. Study design We enrolled 75 pediatric patients with severe sepsis admitted to a tertiary care children's hospital. Plasma ferritin was measured within 48 hours of diagnosis and subsequently twice weekly. Herpes simplex type 1, human herpesvirus 6, Epstein−Barr virus, cytomegalovirus, and adenovirus DNAemia were assessed by polymerase chain reaction. Results The incidence of DNAemia was increased significantly in patients with ferritin ≥1000 ng/mL (78% vs 28%; P < .05). Patients with ferritin ≥1000 ng/mL were more likely to have multiple DNA viruses detected in plasma (39% vs 4%; P < .001). The number of viruses detected in plasma directly correlated with the degree of hyperferritinemia and development of combined hepatobiliary and hematologic dysfunction after we controlled for bacterial and fungal coinfections (P < .05) as well as increased mortality after we controlled for severity of illness and cancer diagnosis (OR 2.6, 95% CI 1.1-6.3, P < .05). Conclusions Viral DNAemia was associated with hyperferritinemia and adverse outcome in pediatric severe sepsis. Prospective studies are needed to determine whether hyperferritinemia may be used to identify patients at risk of occult DNAemia. To evaluate the relationship between detection of DNA viruses, ferritin, and outcomes in children with severe sepsis. We enrolled 75 pediatric patients with severe sepsis admitted to a tertiary care children's hospital. Plasma ferritin was measured within 48 hours of diagnosis and subsequently twice weekly. Herpes simplex type 1, human herpesvirus 6, Epstein−Barr virus, cytomegalovirus, and adenovirus DNAemia were assessed by polymerase chain reaction. The incidence of DNAemia was increased significantly in patients with ferritin ≥1000 ng/mL (78% vs 28%; P < .05). Patients with ferritin ≥1000 ng/mL were more likely to have multiple DNA viruses detected in plasma (39% vs 4%; P < .001). The number of viruses detected in plasma directly correlated with the degree of hyperferritinemia and development of combined hepatobiliary and hematologic dysfunction after we controlled for bacterial and fungal coinfections (P < .05) as well as increased mortality after we controlled for severity of illness and cancer diagnosis (OR 2.6, 95% CI 1.1-6.3, P < .05). Viral DNAemia was associated with hyperferritinemia and adverse outcome in pediatric severe sepsis. Prospective studies are needed to determine whether hyperferritinemia may be used to identify patients at risk of occult DNAemia." @default.
• W2956659207 created "2019-07-23" @default.
• W2956659207 creator A5000715562 @default.
• W2956659207 creator A5008281691 @default.
• W2956659207 creator A5012028041 @default.
• W2956659207 creator A5028478129 @default.
• W2956659207 creator A5058521832 @default.
• W2956659207 creator A5062295043 @default.
• W2956659207 creator A5074292057 @default.
• W2956659207 date "2019-10-01" @default.
• W2956659207 modified "2023-10-01" @default.
• W2956659207 title "DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis" @default.
• W2956659207 cites W1505537322 @default.
• W2956659207 cites W1969296748 @default.
• W2956659207 cites W2006458045 @default.
• W2956659207 cites W2024962779 @default.
• W2956659207 cites W2025430639 @default.
• W2956659207 cites W2043693225 @default.
• W2956659207 cites W2085128602 @default.
• W2956659207 cites W2112855445 @default.
• W2956659207 cites W2119893731 @default.
• W2956659207 cites W2126286427 @default.
• W2956659207 cites W2143012846 @default.
• W2956659207 cites W2145574208 @default.
• W2956659207 cites W2145869286 @default.
• W2956659207 cites W2166395469 @default.
• W2956659207 cites W2169127097 @default.
• W2956659207 cites W2177407033 @default.
• W2956659207 cites W2328429867 @default.
• W2956659207 cites W2472029233 @default.
• W2956659207 cites W2560708839 @default.
• W2956659207 cites W2565022774 @default.
• W2956659207 cites W2585488503 @default.
• W2956659207 cites W2607227420 @default.
• W2956659207 cites W2617626520 @default.
• W2956659207 cites W2619168870 @default.
• W2956659207 cites W2746875537 @default.
• W2956659207 cites W2756170974 @default.
• W2956659207 cites W2768590152 @default.
• W2956659207 cites W2792407982 @default.
• W2956659207 cites W2794731852 @default.
• W2956659207 cites W2802085317 @default.
• W2956659207 cites W2911371912 @default.
• W2956659207 cites W2912679257 @default.
• W2956659207 doi "https://doi.org/10.1016/j.jpeds.2019.06.033" @default.
• W2956659207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765425" @default.
• W2956659207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31303335" @default.
• W2956659207 hasPublicationYear "2019" @default.
• W2956659207 type Work @default.
• W2956659207 sameAs 2956659207 @default.
• W2956659207 citedByCount "14" @default.
• W2956659207 countsByYear W29566592072020 @default.
• W2956659207 countsByYear W29566592072021 @default.
• W2956659207 countsByYear W29566592072022 @default.
• W2956659207 countsByYear W29566592072023 @default.
• W2956659207 crossrefType "journal-article" @default.
• W2956659207 hasAuthorship W2956659207A5000715562 @default.
• W2956659207 hasAuthorship W2956659207A5008281691 @default.
• W2956659207 hasAuthorship W2956659207A5012028041 @default.
• W2956659207 hasAuthorship W2956659207A5028478129 @default.
• W2956659207 hasAuthorship W2956659207A5058521832 @default.
• W2956659207 hasAuthorship W2956659207A5062295043 @default.
• W2956659207 hasAuthorship W2956659207A5074292057 @default.
• W2956659207 hasBestOaLocation W29566592072 @default.
• W2956659207 hasConcept C120665830 @default.
• W2956659207 hasConcept C121332964 @default.
• W2956659207 hasConcept C126322002 @default.
• W2956659207 hasConcept C187212893 @default.
• W2956659207 hasConcept C188816634 @default.
• W2956659207 hasConcept C203014093 @default.
• W2956659207 hasConcept C2522874641 @default.
• W2956659207 hasConcept C2776185481 @default.
• W2956659207 hasConcept C2776409557 @default.
• W2956659207 hasConcept C2777732132 @default.
• W2956659207 hasConcept C2778319317 @default.
• W2956659207 hasConcept C2778384902 @default.
• W2956659207 hasConcept C2780727368 @default.
• W2956659207 hasConcept C2781196997 @default.
• W2956659207 hasConcept C61511704 @default.
• W2956659207 hasConcept C71924100 @default.
• W2956659207 hasConcept C90924648 @default.
• W2956659207 hasConceptScore W2956659207C120665830 @default.
• W2956659207 hasConceptScore W2956659207C121332964 @default.
• W2956659207 hasConceptScore W2956659207C126322002 @default.
• W2956659207 hasConceptScore W2956659207C187212893 @default.
• W2956659207 hasConceptScore W2956659207C188816634 @default.
• W2956659207 hasConceptScore W2956659207C203014093 @default.
• W2956659207 hasConceptScore W2956659207C2522874641 @default.
• W2956659207 hasConceptScore W2956659207C2776185481 @default.
• W2956659207 hasConceptScore W2956659207C2776409557 @default.
• W2956659207 hasConceptScore W2956659207C2777732132 @default.
• W2956659207 hasConceptScore W2956659207C2778319317 @default.
• W2956659207 hasConceptScore W2956659207C2778384902 @default.
• W2956659207 hasConceptScore W2956659207C2780727368 @default.
• W2956659207 hasConceptScore W2956659207C2781196997 @default.
• W2956659207 hasConceptScore W2956659207C61511704 @default.
• W2956659207 hasConceptScore W2956659207C71924100 @default.
• W2956659207 hasConceptScore W2956659207C90924648 @default.

• next