FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956673031> ?p ?o ?g. }

• W2956673031 endingPage "81" @default.
• W2956673031 startingPage "70" @default.
• W2956673031 abstract "Background High expression of denticleless E3 ubiquitin protein ligase homologue (DTL) correlates with poor disease-free survival and overall survival in cutaneous melanoma, but the molecular features and clinical significance of this gene in acral melanoma (AM) remain unclear. Methods The expression levels of DTL were compared between AM and benign melanocytic nevi using existing Gene Expression Omnibus data and validated in fresh frozen tissues. Two candidate tag single-nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of DTL in patients with AM were sequenced and analysed for their association with survival in a discovery cohort (n = 570), and the significant SNP was subjected to a replication cohort (n = 201). The expression of DTL was evaluated by immunohistochemistry. The microRNA interacting with rs11275300:C > G was predicted using in silico target prediction tools and validated by in vitro analysis. Results DTL was overexpressed in AM compared with benign melanocytic nevi. rs11275300:C > G was found to be significantly associated with progression-free survival and overall survival of patients with AM in both cohorts and the combined cohort. Furthermore, the DTL expression level in the patients with the rs11275300:G allele was higher than that in patients with the CC genotype. In vitro analysis demonstrated that DTL was a direct target of hsa-miR-4672, and the rs11275300:G allele interfered with the binding affinity of hsa-miR-4672 with the 3′UTR of DTL and thereby increased DTL expression. Conclusion The rs11275300:G allele in the 3′UTR of DTL may lead to a poor prognosis and allele-specific increase in the expression of DTL by post-transcriptional regulation in AM." @default.
• W2956673031 created "2019-07-23" @default.
• W2956673031 creator A5005251933 @default.
• W2956673031 creator A5007562507 @default.
• W2956673031 creator A5009201250 @default.
• W2956673031 creator A5018372804 @default.
• W2956673031 creator A5024956586 @default.
• W2956673031 creator A5035685296 @default.
• W2956673031 creator A5043882241 @default.
• W2956673031 creator A5050619645 @default.
• W2956673031 creator A5055356574 @default.
• W2956673031 creator A5068116429 @default.
• W2956673031 creator A5069813415 @default.
• W2956673031 creator A5079921592 @default.
• W2956673031 creator A5084636770 @default.
• W2956673031 date "2019-09-01" @default.
• W2956673031 modified "2023-10-15" @default.
• W2956673031 title "Identification of a functional polymorphism within the 3′-untranslated region of denticleless E3 ubiquitin protein ligase homolog associated with survival in acral melanoma" @default.
• W2956673031 cites W144423133 @default.
• W2956673031 cites W1757407923 @default.
• W2956673031 cites W1846410774 @default.
• W2956673031 cites W1950829641 @default.
• W2956673031 cites W1973190617 @default.
• W2956673031 cites W1989121777 @default.
• W2956673031 cites W1995461329 @default.
• W2956673031 cites W2004563850 @default.
• W2956673031 cites W2021753885 @default.
• W2956673031 cites W2031189137 @default.
• W2956673031 cites W2058772642 @default.
• W2956673031 cites W2060913442 @default.
• W2956673031 cites W2068237418 @default.
• W2956673031 cites W2069926873 @default.
• W2956673031 cites W2074695992 @default.
• W2956673031 cites W2077327925 @default.
• W2956673031 cites W2077813812 @default.
• W2956673031 cites W2080834212 @default.
• W2956673031 cites W2088140119 @default.
• W2956673031 cites W2094253263 @default.
• W2956673031 cites W2099200814 @default.
• W2956673031 cites W2104096707 @default.
• W2956673031 cites W2107914050 @default.
• W2956673031 cites W2115346583 @default.
• W2956673031 cites W2119760558 @default.
• W2956673031 cites W2125040419 @default.
• W2956673031 cites W2125637479 @default.
• W2956673031 cites W2134629862 @default.
• W2956673031 cites W2137250828 @default.
• W2956673031 cites W2144548050 @default.
• W2956673031 cites W2148928098 @default.
• W2956673031 cites W2151025094 @default.
• W2956673031 cites W2319760433 @default.
• W2956673031 cites W2420376897 @default.
• W2956673031 cites W2537645495 @default.
• W2956673031 cites W2611187032 @default.
• W2956673031 cites W2621161007 @default.
• W2956673031 cites W2739436552 @default.
• W2956673031 cites W2785897649 @default.
• W2956673031 doi "https://doi.org/10.1016/j.ejca.2019.06.006" @default.
• W2956673031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31325875" @default.
• W2956673031 hasPublicationYear "2019" @default.
• W2956673031 type Work @default.
• W2956673031 sameAs 2956673031 @default.
• W2956673031 citedByCount "11" @default.
• W2956673031 countsByYear W29566730312020 @default.
• W2956673031 countsByYear W29566730312021 @default.
• W2956673031 countsByYear W29566730312022 @default.
• W2956673031 crossrefType "journal-article" @default.
• W2956673031 hasAuthorship W2956673031A5005251933 @default.
• W2956673031 hasAuthorship W2956673031A5007562507 @default.
• W2956673031 hasAuthorship W2956673031A5009201250 @default.
• W2956673031 hasAuthorship W2956673031A5018372804 @default.
• W2956673031 hasAuthorship W2956673031A5024956586 @default.
• W2956673031 hasAuthorship W2956673031A5035685296 @default.
• W2956673031 hasAuthorship W2956673031A5043882241 @default.
• W2956673031 hasAuthorship W2956673031A5050619645 @default.
• W2956673031 hasAuthorship W2956673031A5055356574 @default.
• W2956673031 hasAuthorship W2956673031A5068116429 @default.
• W2956673031 hasAuthorship W2956673031A5069813415 @default.
• W2956673031 hasAuthorship W2956673031A5079921592 @default.
• W2956673031 hasAuthorship W2956673031A5084636770 @default.
• W2956673031 hasConcept C104317684 @default.
• W2956673031 hasConcept C10515644 @default.
• W2956673031 hasConcept C105580179 @default.
• W2956673031 hasConcept C126322002 @default.
• W2956673031 hasConcept C134459356 @default.
• W2956673031 hasConcept C135763542 @default.
• W2956673031 hasConcept C139275648 @default.
• W2956673031 hasConcept C153209595 @default.
• W2956673031 hasConcept C153911025 @default.
• W2956673031 hasConcept C180754005 @default.
• W2956673031 hasConcept C22667442 @default.
• W2956673031 hasConcept C25602115 @default.
• W2956673031 hasConcept C2777658100 @default.
• W2956673031 hasConcept C502942594 @default.
• W2956673031 hasConcept C54355233 @default.
• W2956673031 hasConcept C71924100 @default.
• W2956673031 hasConcept C86803240 @default.
• W2956673031 hasConcept C89604277 @default.

• next