Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956829512> ?p ?o ?g. }
- W2956829512 abstract "The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tracing established that Hey-deficient ECs are unable to maintain their unique nuclear organization and identity. To supervise cell identity, Hey determines the expression of nuclear lamins, switching from a stem-cell lamin configuration to a differentiated lamin configuration. Moreover, continued Hey expression is required to conserve large-scale nuclear organization. During aging, Hey levels decline, and EC identity and gut homeostasis are impaired, including pathological reprograming and compromised gut integrity. These phenotypes are highly similar to those observed upon acute targeting of Hey or perturbation of lamin expression in ECs in young adults. Indeed, aging phenotypes were suppressed by continued expression of Hey in ECs, suggesting that a Hey-lamin network safeguards nuclear organization and differentiated cell identity." @default.
- W2956829512 created "2019-07-23" @default.
- W2956829512 creator A5016456262 @default.
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- W2956829512 creator A5029759181 @default.
- W2956829512 creator A5044858337 @default.
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- W2956829512 creator A5058994120 @default.
- W2956829512 creator A5079767149 @default.
- W2956829512 creator A5081175102 @default.
- W2956829512 date "2019-07-16" @default.
- W2956829512 modified "2023-10-01" @default.
- W2956829512 title "The transcription factor Hey and nuclear lamins specify and maintain cell identity" @default.
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