Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956833392> ?p ?o ?g. }
- W2956833392 endingPage "F622" @default.
- W2956833392 startingPage "F616" @default.
- W2956833392 abstract "Transplanted kidneys usually experience several episodes of ischemia, including cold ischemia during allograft storage in preservation solution. However, previous studies focusing on cold renal ischemia were only carried out in vitro or ex vivo. In the present study, we developed and characterized an in vivo mouse model of renal ischemia-reperfusion injury (IRI) induced exclusively by cold ischemia. C57BL/6 mice underwent right kidney nephrectomy, and the left kidney was kept cool with circulating cold saline in a kidney cup, while body temperature was maintained at 37°C. We clamped the renal pedicle and flushed out the blood inside the kidney with cold saline via an opening on the renal vein. The severity of renal IRI was examined with different ischemic durations. We found that the mice with <2 h of cold ischemia exhibited no significant changes in renal function or histopathology; animals with 3 or 4 h of cold ischemia developed into mild to moderate acute kidney injury with characteristic features, including the elevation in plasma creatinine concentration and reduction in glomerular filtration rate and tubular necrosis, followed by a subsequent recovery. However, mice with 5 h of cold ischemia died in a few days with severe acute kidney injury. In summary, we generated a mouse model of renal IRI induced exclusively by cold ischemia, which mimics graft cold storage in preservation solution, and renal function can be evaluated in vivo." @default.
- W2956833392 created "2019-07-23" @default.
- W2956833392 creator A5012014330 @default.
- W2956833392 creator A5032745814 @default.
- W2956833392 creator A5041167897 @default.
- W2956833392 creator A5045686015 @default.
- W2956833392 creator A5057082599 @default.
- W2956833392 creator A5058401524 @default.
- W2956833392 creator A5073216396 @default.
- W2956833392 creator A5073501391 @default.
- W2956833392 date "2019-09-01" @default.
- W2956833392 modified "2023-09-27" @default.
- W2956833392 title "A mouse model of renal ischemia-reperfusion injury solely induced by cold ischemia" @default.
- W2956833392 cites W14309507 @default.
- W2956833392 cites W1515316319 @default.
- W2956833392 cites W1542731846 @default.
- W2956833392 cites W1594585245 @default.
- W2956833392 cites W1744376040 @default.
- W2956833392 cites W1829133912 @default.
- W2956833392 cites W1966515341 @default.
- W2956833392 cites W1967593017 @default.
- W2956833392 cites W1971799714 @default.
- W2956833392 cites W1976259910 @default.
- W2956833392 cites W1976651797 @default.
- W2956833392 cites W1979817372 @default.
- W2956833392 cites W1990140067 @default.
- W2956833392 cites W1999085389 @default.
- W2956833392 cites W2002751122 @default.
- W2956833392 cites W2009308812 @default.
- W2956833392 cites W2012864757 @default.
- W2956833392 cites W2014894287 @default.
- W2956833392 cites W2016203818 @default.
- W2956833392 cites W2020859230 @default.
- W2956833392 cites W2026399893 @default.
- W2956833392 cites W2038015207 @default.
- W2956833392 cites W2052243907 @default.
- W2956833392 cites W2059950347 @default.
- W2956833392 cites W2060860593 @default.
- W2956833392 cites W2064058319 @default.
- W2956833392 cites W2069810173 @default.
- W2956833392 cites W2070030638 @default.
- W2956833392 cites W2073625832 @default.
- W2956833392 cites W2099632521 @default.
- W2956833392 cites W2111998129 @default.
- W2956833392 cites W2114046963 @default.
- W2956833392 cites W2127558607 @default.
- W2956833392 cites W2142944825 @default.
- W2956833392 cites W2150371282 @default.
- W2956833392 cites W2160807970 @default.
- W2956833392 cites W2241870771 @default.
- W2956833392 cites W2263588780 @default.
- W2956833392 cites W2322187697 @default.
- W2956833392 cites W2340429612 @default.
- W2956833392 cites W2342967759 @default.
- W2956833392 cites W2405183840 @default.
- W2956833392 cites W2411875797 @default.
- W2956833392 cites W2552179401 @default.
- W2956833392 cites W2615491055 @default.
- W2956833392 cites W2770581098 @default.
- W2956833392 cites W2786351196 @default.
- W2956833392 cites W2799884370 @default.
- W2956833392 cites W2805472385 @default.
- W2956833392 cites W2922268276 @default.
- W2956833392 doi "https://doi.org/10.1152/ajprenal.00533.2018" @default.
- W2956833392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6766631" @default.
- W2956833392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31291121" @default.
- W2956833392 hasPublicationYear "2019" @default.
- W2956833392 type Work @default.
- W2956833392 sameAs 2956833392 @default.
- W2956833392 citedByCount "15" @default.
- W2956833392 countsByYear W29568333922019 @default.
- W2956833392 countsByYear W29568333922020 @default.
- W2956833392 countsByYear W29568333922021 @default.
- W2956833392 countsByYear W29568333922022 @default.
- W2956833392 countsByYear W29568333922023 @default.
- W2956833392 crossrefType "journal-article" @default.
- W2956833392 hasAuthorship W2956833392A5012014330 @default.
- W2956833392 hasAuthorship W2956833392A5032745814 @default.
- W2956833392 hasAuthorship W2956833392A5041167897 @default.
- W2956833392 hasAuthorship W2956833392A5045686015 @default.
- W2956833392 hasAuthorship W2956833392A5057082599 @default.
- W2956833392 hasAuthorship W2956833392A5058401524 @default.
- W2956833392 hasAuthorship W2956833392A5073216396 @default.
- W2956833392 hasAuthorship W2956833392A5073501391 @default.
- W2956833392 hasBestOaLocation W29568333921 @default.
- W2956833392 hasConcept C126322002 @default.
- W2956833392 hasConcept C126894567 @default.
- W2956833392 hasConcept C144027150 @default.
- W2956833392 hasConcept C150903083 @default.
- W2956833392 hasConcept C159641895 @default.
- W2956833392 hasConcept C207001950 @default.
- W2956833392 hasConcept C26291073 @default.
- W2956833392 hasConcept C2777350860 @default.
- W2956833392 hasConcept C2777397205 @default.
- W2956833392 hasConcept C2780091579 @default.
- W2956833392 hasConcept C2780114680 @default.
- W2956833392 hasConcept C2780227381 @default.
- W2956833392 hasConcept C2780721119 @default.