Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956849062> ?p ?o ?g. }
- W2956849062 endingPage "385" @default.
- W2956849062 startingPage "365" @default.
- W2956849062 abstract "The human T cell leukemia virus persists in vivo in 103 to 106 clones of T lymphocytes that appear to survive for the lifetime of the host. The plus strand of the provirus is typically transcriptionally silent in freshly isolated lymphocytes, but the strong, persistently activated cytotoxic T lymphocyte (CTL) response to the viral antigens indicates that the virus is not constantly latent in vivo. There is now evidence that the plus strand is transcribed in intense intermittent bursts that are triggered by cellular stress, modulated by hypoxia and glycolysis, and inhibited by polycomb repressive complex 1 (PRC1). The minus-strand gene hbz is transcribed at a lower, more constant level but is silent in a proportion of infected cells at a given time. Viral genes in the sense and antisense strands of the provirus play different respective roles in latency and de novo infection: Expression of the plus-strand gene tax is essential for de novo infection, whereas hbz appears to facilitate survival of the infected T cell clone in vivo." @default.
- W2956849062 created "2019-07-23" @default.
- W2956849062 creator A5004109703 @default.
- W2956849062 creator A5019527890 @default.
- W2956849062 creator A5021361091 @default.
- W2956849062 creator A5037389725 @default.
- W2956849062 date "2019-09-29" @default.
- W2956849062 modified "2023-09-27" @default.
- W2956849062 title "Regulation of Latency in the Human T Cell Leukemia Virus, HTLV-1" @default.
- W2956849062 cites W1500263965 @default.
- W2956849062 cites W1505665725 @default.
- W2956849062 cites W1531198730 @default.
- W2956849062 cites W1586205537 @default.
- W2956849062 cites W1798326710 @default.
- W2956849062 cites W1849097877 @default.
- W2956849062 cites W1964184081 @default.
- W2956849062 cites W1966278500 @default.
- W2956849062 cites W1966430811 @default.
- W2956849062 cites W1968931043 @default.
- W2956849062 cites W1969937142 @default.
- W2956849062 cites W1971879015 @default.
- W2956849062 cites W1976713539 @default.
- W2956849062 cites W1980448649 @default.
- W2956849062 cites W1984827465 @default.
- W2956849062 cites W1984903732 @default.
- W2956849062 cites W1985471077 @default.
- W2956849062 cites W1989840044 @default.
- W2956849062 cites W1990875684 @default.
- W2956849062 cites W1992115934 @default.
- W2956849062 cites W1993340203 @default.
- W2956849062 cites W1995495460 @default.
- W2956849062 cites W1996328190 @default.
- W2956849062 cites W1996809486 @default.
- W2956849062 cites W1997923723 @default.
- W2956849062 cites W1998001924 @default.
- W2956849062 cites W2000982327 @default.
- W2956849062 cites W2004467026 @default.
- W2956849062 cites W2008383971 @default.
- W2956849062 cites W2018016807 @default.
- W2956849062 cites W2019078072 @default.
- W2956849062 cites W2020002174 @default.
- W2956849062 cites W2027392116 @default.
- W2956849062 cites W2031528009 @default.
- W2956849062 cites W2033505817 @default.
- W2956849062 cites W2033890654 @default.
- W2956849062 cites W2039910403 @default.
- W2956849062 cites W2043248836 @default.
- W2956849062 cites W2045443908 @default.
- W2956849062 cites W2045651327 @default.
- W2956849062 cites W2052700342 @default.
- W2956849062 cites W2056081718 @default.
- W2956849062 cites W2056743008 @default.
- W2956849062 cites W2060146090 @default.
- W2956849062 cites W2062989840 @default.
- W2956849062 cites W2064416623 @default.
- W2956849062 cites W2068100440 @default.
- W2956849062 cites W2071794490 @default.
- W2956849062 cites W2077509257 @default.
- W2956849062 cites W2077677492 @default.
- W2956849062 cites W2078526277 @default.
- W2956849062 cites W2080441045 @default.
- W2956849062 cites W2084037323 @default.
- W2956849062 cites W2084714153 @default.
- W2956849062 cites W2086629747 @default.
- W2956849062 cites W2087608460 @default.
- W2956849062 cites W2088727289 @default.
- W2956849062 cites W2090462024 @default.
- W2956849062 cites W2091175727 @default.
- W2956849062 cites W2092834432 @default.
- W2956849062 cites W2094201832 @default.
- W2956849062 cites W2094831592 @default.
- W2956849062 cites W2095002834 @default.
- W2956849062 cites W2095016270 @default.
- W2956849062 cites W2104358213 @default.
- W2956849062 cites W2105512180 @default.
- W2956849062 cites W2107359522 @default.
- W2956849062 cites W2110018477 @default.
- W2956849062 cites W2111169409 @default.
- W2956849062 cites W2114538357 @default.
- W2956849062 cites W2114870653 @default.
- W2956849062 cites W2115382610 @default.
- W2956849062 cites W2115580899 @default.
- W2956849062 cites W2115685806 @default.
- W2956849062 cites W2125572458 @default.
- W2956849062 cites W2127455821 @default.
- W2956849062 cites W2129629573 @default.
- W2956849062 cites W2131577457 @default.
- W2956849062 cites W2133301780 @default.
- W2956849062 cites W2134170049 @default.
- W2956849062 cites W2134594325 @default.
- W2956849062 cites W2134646503 @default.
- W2956849062 cites W2141688036 @default.
- W2956849062 cites W2146526539 @default.
- W2956849062 cites W2148445464 @default.
- W2956849062 cites W2149850078 @default.
- W2956849062 cites W2156661621 @default.
- W2956849062 cites W2157234590 @default.
- W2956849062 cites W2157527261 @default.