FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956856445> ?p ?o ?g. }

• W2956856445 endingPage "1646" @default.
• W2956856445 startingPage "1636" @default.
• W2956856445 abstract "WNT signaling is of key importance in chondrogenesis and defective WNT signaling may contribute to the pathogenesis of osteoarthritis and other cartilage diseases. Biochemical composition of articular cartilage in patients with aberrant WNT signaling has not been studied. Our objective was to assess the knee articular cartilage in WNT1 mutation-positive individuals using a 3.0T MRI unit to measure cartilage thickness, relaxation times, and texture features.Cohort comprised mutation-positive (N = 13; age 17-76 years) and mutation-negative (N = 13; 16-77 years) subjects from two Finnish families with autosomal dominant WNT1 osteoporosis due to a heterozygous missense mutation c.652T>G (p.C218G) in WNT1. All subjects were imaged with a 3.0T MRI unit and assessed for cartilage thickness, T2 and T1ρ relaxation times, and T2 texture features contrast, dissimilarity and homogeneity of T2 relaxation time maps in six regions of interest (ROIs) in the tibiofemoral cartilage.All three texture features showed opposing trends with age between the groups in the medial tibiofemoral cartilage (P = 0.020-0.085 for the difference of the regression coefficients), the mutation-positive individuals showing signs of cartilage preservation. No significant differences were observed in the lateral tibiofemoral cartilage. Cartilage thickness and means of T2 relaxation time did not differ between groups. Means of T1ρ relaxation time were significantly different in one ROI but the regression analysis displayed no differences.Our results show less age-related cartilage deterioration in the WNT1 mutation-positive than the mutation-negative subjects. This suggests, that the WNT1 mutation may alter cartilage turnover and even have a potential cartilage-preserving effect." @default.
• W2956856445 created "2019-07-23" @default.
• W2956856445 creator A5010697918 @default.
• W2956856445 creator A5011070387 @default.
• W2956856445 creator A5022305760 @default.
• W2956856445 creator A5030741041 @default.
• W2956856445 creator A5036286221 @default.
• W2956856445 creator A5051688538 @default.
• W2956856445 creator A5064764888 @default.
• W2956856445 creator A5073396315 @default.
• W2956856445 creator A5077991621 @default.
• W2956856445 creator A5088428484 @default.
• W2956856445 date "2019-11-01" @default.
• W2956856445 modified "2023-10-09" @default.
• W2956856445 title "Defective WNT signaling may protect from articular cartilage deterioration – a quantitative MRI study on subjects with a heterozygous WNT1 mutation" @default.
• W2956856445 cites W1582105160 @default.
• W2956856445 cites W1800298632 @default.
• W2956856445 cites W1968814115 @default.
• W2956856445 cites W1969108613 @default.
• W2956856445 cites W1971713712 @default.
• W2956856445 cites W1980414538 @default.
• W2956856445 cites W1986085728 @default.
• W2956856445 cites W1989724036 @default.
• W2956856445 cites W1992742436 @default.
• W2956856445 cites W1993877737 @default.
• W2956856445 cites W1995401177 @default.
• W2956856445 cites W1998470513 @default.
• W2956856445 cites W2005931143 @default.
• W2956856445 cites W2009897601 @default.
• W2956856445 cites W2015765825 @default.
• W2956856445 cites W2019055276 @default.
• W2956856445 cites W2019223535 @default.
• W2956856445 cites W2021338453 @default.
• W2956856445 cites W2031371475 @default.
• W2956856445 cites W2040975183 @default.
• W2956856445 cites W2042671010 @default.
• W2956856445 cites W2043591149 @default.
• W2956856445 cites W2044465660 @default.
• W2956856445 cites W2045660383 @default.
• W2956856445 cites W2054019716 @default.
• W2956856445 cites W2059453592 @default.
• W2956856445 cites W2060235532 @default.
• W2956856445 cites W2064101166 @default.
• W2956856445 cites W2064327730 @default.
• W2956856445 cites W2065131544 @default.
• W2956856445 cites W2066434686 @default.
• W2956856445 cites W2078095142 @default.
• W2956856445 cites W2078440118 @default.
• W2956856445 cites W2078816525 @default.
• W2956856445 cites W2092868973 @default.
• W2956856445 cites W2093588591 @default.
• W2956856445 cites W2096983207 @default.
• W2956856445 cites W2101066927 @default.
• W2956856445 cites W2101171643 @default.
• W2956856445 cites W2101679106 @default.
• W2956856445 cites W2105429489 @default.
• W2956856445 cites W2110533062 @default.
• W2956856445 cites W2112948479 @default.
• W2956856445 cites W2117410967 @default.
• W2956856445 cites W2126999941 @default.
• W2956856445 cites W2128650484 @default.
• W2956856445 cites W2134046826 @default.
• W2956856445 cites W2135495486 @default.
• W2956856445 cites W2140652765 @default.
• W2956856445 cites W2142952274 @default.
• W2956856445 cites W2155377428 @default.
• W2956856445 cites W2160211802 @default.
• W2956856445 cites W2192641655 @default.
• W2956856445 cites W2219778256 @default.
• W2956856445 cites W2289170823 @default.
• W2956856445 cites W2302958989 @default.
• W2956856445 cites W2580555116 @default.
• W2956856445 cites W2605784129 @default.
• W2956856445 cites W2740703570 @default.
• W2956856445 cites W2769705592 @default.
• W2956856445 cites W2886710821 @default.
• W2956856445 cites W2896858209 @default.
• W2956856445 cites W2942698198 @default.
• W2956856445 doi "https://doi.org/10.1016/j.joca.2019.07.001" @default.
• W2956856445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31299386" @default.
• W2956856445 hasPublicationYear "2019" @default.
• W2956856445 type Work @default.
• W2956856445 sameAs 2956856445 @default.
• W2956856445 citedByCount "6" @default.
• W2956856445 countsByYear W29568564452020 @default.
• W2956856445 countsByYear W29568564452021 @default.
• W2956856445 countsByYear W29568564452022 @default.
• W2956856445 crossrefType "journal-article" @default.
• W2956856445 hasAuthorship W2956856445A5010697918 @default.
• W2956856445 hasAuthorship W2956856445A5011070387 @default.
• W2956856445 hasAuthorship W2956856445A5022305760 @default.
• W2956856445 hasAuthorship W2956856445A5030741041 @default.
• W2956856445 hasAuthorship W2956856445A5036286221 @default.
• W2956856445 hasAuthorship W2956856445A5051688538 @default.
• W2956856445 hasAuthorship W2956856445A5064764888 @default.
• W2956856445 hasAuthorship W2956856445A5073396315 @default.
• W2956856445 hasAuthorship W2956856445A5077991621 @default.
• W2956856445 hasAuthorship W2956856445A5088428484 @default.

• next