Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956953673> ?p ?o ?g. }
- W2956953673 abstract "The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria parasite, chorismate is postulated to be a direct precursor in the synthesis of p -aminobenzoic acid (folate biosynthesis), p -hydroxybenzoic acid (ubiquinone biosynthesis), menaquinone, and aromatic amino acids. While the potential value of the shikimate pathway as a drug target is debatable, the metabolic dependency of chorismate in P. falciparum remains unclear. Current evidence suggests that the main role of chorismate is folate biosynthesis despite ubiquinone biosynthesis being active and essential in the malaria parasite. Our goal in the present work was to expand our knowledge of the ubiquinone head group biosynthesis and its potential metabolic dependency on chorismate in P. falciparum. These data led us to further characterize the mechanism of action of MMV688345, a compound from the open-access “Pathogen Box” collection from Medicine for Malaria Venture. We systematically assessed the development of both asexual and sexual stages of P. falciparum in a defined medium in the absence of an exogenous supply of chorismate end-products and present biochemical evidence suggesting that the benzoquinone ring of ubiquinones in this parasite may be synthesized through a yet unidentified route." @default.
- W2956953673 created "2019-07-23" @default.
- W2956953673 creator A5005077886 @default.
- W2956953673 creator A5009267893 @default.
- W2956953673 creator A5023146346 @default.
- W2956953673 creator A5045399174 @default.
- W2956953673 creator A5046657466 @default.
- W2956953673 creator A5047530543 @default.
- W2956953673 creator A5056363175 @default.
- W2956953673 creator A5065525543 @default.
- W2956953673 date "2019-07-13" @default.
- W2956953673 modified "2023-10-16" @default.
- W2956953673 title "Metabolic dependency of chorismate in Plasmodium falciparum" @default.
- W2956953673 cites W1614951586 @default.
- W2956953673 cites W1668167434 @default.
- W2956953673 cites W1923619708 @default.
- W2956953673 cites W1973541179 @default.
- W2956953673 cites W1976977157 @default.
- W2956953673 cites W1977041255 @default.
- W2956953673 cites W1980479317 @default.
- W2956953673 cites W1990357087 @default.
- W2956953673 cites W1991686350 @default.
- W2956953673 cites W2002375963 @default.
- W2956953673 cites W2005926903 @default.
- W2956953673 cites W2013327815 @default.
- W2956953673 cites W2018607102 @default.
- W2956953673 cites W2019851585 @default.
- W2956953673 cites W2029301225 @default.
- W2956953673 cites W2038641359 @default.
- W2956953673 cites W2046637912 @default.
- W2956953673 cites W2048671997 @default.
- W2956953673 cites W2059257421 @default.
- W2956953673 cites W2059456698 @default.
- W2956953673 cites W2077772934 @default.
- W2956953673 cites W2083604643 @default.
- W2956953673 cites W2086460760 @default.
- W2956953673 cites W2095458479 @default.
- W2956953673 cites W2096163751 @default.
- W2956953673 cites W2099342830 @default.
- W2956953673 cites W2104277175 @default.
- W2956953673 cites W2104367752 @default.
- W2956953673 cites W2111693807 @default.
- W2956953673 cites W2114818342 @default.
- W2956953673 cites W2118736830 @default.
- W2956953673 cites W2127980504 @default.
- W2956953673 cites W2129999344 @default.
- W2956953673 cites W2133145959 @default.
- W2956953673 cites W2141026950 @default.
- W2956953673 cites W2143552714 @default.
- W2956953673 cites W2161273888 @default.
- W2956953673 cites W2163407071 @default.
- W2956953673 cites W2167315879 @default.
- W2956953673 cites W2168275452 @default.
- W2956953673 cites W2169230642 @default.
- W2956953673 cites W2170680268 @default.
- W2956953673 cites W2332788689 @default.
- W2956953673 cites W2414931125 @default.
- W2956953673 cites W2467614481 @default.
- W2956953673 cites W2488914148 @default.
- W2956953673 cites W2512605033 @default.
- W2956953673 cites W2518292292 @default.
- W2956953673 cites W2600445152 @default.
- W2956953673 cites W2736273628 @default.
- W2956953673 cites W2754373993 @default.
- W2956953673 cites W2765167818 @default.
- W2956953673 cites W2775548182 @default.
- W2956953673 cites W2800834635 @default.
- W2956953673 cites W2906906692 @default.
- W2956953673 cites W2909833902 @default.
- W2956953673 cites W2914301819 @default.
- W2956953673 cites W4241242732 @default.
- W2956953673 cites W2783648087 @default.
- W2956953673 doi "https://doi.org/10.1101/698951" @default.
- W2956953673 hasPublicationYear "2019" @default.
- W2956953673 type Work @default.
- W2956953673 sameAs 2956953673 @default.
- W2956953673 citedByCount "0" @default.
- W2956953673 crossrefType "posted-content" @default.
- W2956953673 hasAuthorship W2956953673A5005077886 @default.
- W2956953673 hasAuthorship W2956953673A5009267893 @default.
- W2956953673 hasAuthorship W2956953673A5023146346 @default.
- W2956953673 hasAuthorship W2956953673A5045399174 @default.
- W2956953673 hasAuthorship W2956953673A5046657466 @default.
- W2956953673 hasAuthorship W2956953673A5047530543 @default.
- W2956953673 hasAuthorship W2956953673A5056363175 @default.
- W2956953673 hasAuthorship W2956953673A5065525543 @default.
- W2956953673 hasBestOaLocation W29569536731 @default.
- W2956953673 hasConcept C181199279 @default.
- W2956953673 hasConcept C192989942 @default.
- W2956953673 hasConcept C203014093 @default.
- W2956953673 hasConcept C2777477808 @default.
- W2956953673 hasConcept C2778048844 @default.
- W2956953673 hasConcept C2778255928 @default.
- W2956953673 hasConcept C2778371730 @default.
- W2956953673 hasConcept C2781440633 @default.
- W2956953673 hasConcept C553450214 @default.
- W2956953673 hasConcept C55493867 @default.
- W2956953673 hasConcept C62231903 @default.
- W2956953673 hasConcept C86803240 @default.
- W2956953673 hasConceptScore W2956953673C181199279 @default.