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• W2956974025 abstract "Ctn[15‐34], a downsized version of the snake venom cathelicidin‐like peptide crotalicidin (Ctn), shows an unusually high lifespan ( t 1/2 , approximately 12 h) in human serum, which significantly adds to its promise as an antimicrobial and antitumor agent. Herein we investigate the role of Ctn[15‐34] structure on serum survival. Using a set of analogs, we show that C‐terminal amidation, as well as the specific layout of the Ctn[15‐34] sequence—a helical N‐terminal domain followed by a hydrophobic domain—is crucial for slow degradation, and any change in their arrangement results in significantly lower t 1/2 . Aside from the privileged primary structure, features such as self‐aggregation can be ruled out as causes for the long serum life. Instead, studies in other protease‐rich fluids suggest a key role for certain human serum components. Finally, we demonstrate that Ctn[15‐34] is able to induce bacterial death even after 12‐hour pre‐incubation in serum, in agreement with the proteolytic data. Altogether, the results shed light on the uncommon stability of Ctn[15‐34] in human serum and confirm its potential as an anti‐infective lead." @default.
• W2956974025 created "2019-07-23" @default.
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• W2956974025 date "2019-07-17" @default.
• W2956974025 modified "2023-09-30" @default.
• W2956974025 title "Structural determinants conferring unusual long life in human serum to rattlesnake‐derived antimicrobial peptide Ctn[15‐34]" @default.
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• W2956974025 doi "https://doi.org/10.1002/psc.3195" @default.
• W2956974025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31317613" @default.
• W2956974025 hasPublicationYear "2019" @default.
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