Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957059501> ?p ?o ?g. }
- W2957059501 endingPage "1400" @default.
- W2957059501 startingPage "1391" @default.
- W2957059501 abstract "The treatment of enterococcal infections is becoming more difficult because of multidrug resistance (MDR). Lupinifolin, a prenylated flavonoid isolated from Albizia myriophylla Benth., showed a potent antimicrobial activity against enterococci. The aim of this study was to investigate antibacterial activity and action of lupinifolin against MDR enterococcal clinical isolates. Antibacterial properties of lupinifolin against 21 MDR isolates were assessed using broth microdilution method and time–kill assay. To study mode of action of lupinifolin on the isolates, propidium iodide intensity, salt tolerance assay, and electron microscopic analyses were performed. Antibiofilm formation activity of lupinifolin was conducted using crytal violet assay. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration values of lupinifolin against the isolates ranged between 0.5 and 2.0 μg/mL and between 2 and 16 μg/mL, respectively. Lupinifolin at 2MIC and 4MIC inhibited the bacterial growth >2 log colony-forming units (CFU)/mL at 2 hr incubation by time–kill analysis. The compound increased membrane permeability and caused loss of salt tolerance. SEM and TEM micrographs revealed pronounced morphological and ultrastructural changes in the treated bacteria. Crystal violet staining showed the antibiofilm-producing activity of lupinifolin against four MDR enterococci. This study suggested that lupinifolin is an essential antimicrobial agent that could be useful for the treatment of MDR enterococcal infections." @default.
- W2957059501 created "2019-07-23" @default.
- W2957059501 creator A5002959957 @default.
- W2957059501 creator A5021419958 @default.
- W2957059501 creator A5035221486 @default.
- W2957059501 creator A5058564266 @default.
- W2957059501 date "2019-12-01" @default.
- W2957059501 modified "2023-09-26" @default.
- W2957059501 title "Mechanism of Action and Biofilm Inhibitory Activity of Lupinifolin Against Multidrug-Resistant Enterococcal Clinical Isolates" @default.
- W2957059501 cites W1690368637 @default.
- W2957059501 cites W1820783321 @default.
- W2957059501 cites W1963776097 @default.
- W2957059501 cites W1976667730 @default.
- W2957059501 cites W1981548542 @default.
- W2957059501 cites W1999744191 @default.
- W2957059501 cites W2000242554 @default.
- W2957059501 cites W2010135598 @default.
- W2957059501 cites W2013082191 @default.
- W2957059501 cites W2016157118 @default.
- W2957059501 cites W2016158447 @default.
- W2957059501 cites W2025957152 @default.
- W2957059501 cites W2030769320 @default.
- W2957059501 cites W2036066012 @default.
- W2957059501 cites W2053780815 @default.
- W2957059501 cites W2065011148 @default.
- W2957059501 cites W2067477145 @default.
- W2957059501 cites W2070007526 @default.
- W2957059501 cites W2074968287 @default.
- W2957059501 cites W2082168464 @default.
- W2957059501 cites W2084585664 @default.
- W2957059501 cites W2103599303 @default.
- W2957059501 cites W2106503480 @default.
- W2957059501 cites W2106893686 @default.
- W2957059501 cites W2107213260 @default.
- W2957059501 cites W2108580921 @default.
- W2957059501 cites W2113629007 @default.
- W2957059501 cites W2125266622 @default.
- W2957059501 cites W2139700741 @default.
- W2957059501 cites W2156247972 @default.
- W2957059501 cites W2156468063 @default.
- W2957059501 cites W2162377507 @default.
- W2957059501 cites W2314290989 @default.
- W2957059501 cites W2460894723 @default.
- W2957059501 cites W2560008734 @default.
- W2957059501 cites W2567199292 @default.
- W2957059501 cites W2734765068 @default.
- W2957059501 cites W2765943493 @default.
- W2957059501 cites W2771507205 @default.
- W2957059501 cites W2793638444 @default.
- W2957059501 cites W4210969014 @default.
- W2957059501 cites W4230357700 @default.
- W2957059501 doi "https://doi.org/10.1089/mdr.2018.0391" @default.
- W2957059501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31314663" @default.
- W2957059501 hasPublicationYear "2019" @default.
- W2957059501 type Work @default.
- W2957059501 sameAs 2957059501 @default.
- W2957059501 citedByCount "9" @default.
- W2957059501 countsByYear W29570595012020 @default.
- W2957059501 countsByYear W29570595012021 @default.
- W2957059501 countsByYear W29570595012022 @default.
- W2957059501 countsByYear W29570595012023 @default.
- W2957059501 crossrefType "journal-article" @default.
- W2957059501 hasAuthorship W2957059501A5002959957 @default.
- W2957059501 hasAuthorship W2957059501A5021419958 @default.
- W2957059501 hasAuthorship W2957059501A5035221486 @default.
- W2957059501 hasAuthorship W2957059501A5058564266 @default.
- W2957059501 hasConcept C114851261 @default.
- W2957059501 hasConcept C133936738 @default.
- W2957059501 hasConcept C176947019 @default.
- W2957059501 hasConcept C190283241 @default.
- W2957059501 hasConcept C2775934118 @default.
- W2957059501 hasConcept C2776020440 @default.
- W2957059501 hasConcept C2780950330 @default.
- W2957059501 hasConcept C31573885 @default.
- W2957059501 hasConcept C4937899 @default.
- W2957059501 hasConcept C523546767 @default.
- W2957059501 hasConcept C54355233 @default.
- W2957059501 hasConcept C55493867 @default.
- W2957059501 hasConcept C58123911 @default.
- W2957059501 hasConcept C86803240 @default.
- W2957059501 hasConcept C89423630 @default.
- W2957059501 hasConceptScore W2957059501C114851261 @default.
- W2957059501 hasConceptScore W2957059501C133936738 @default.
- W2957059501 hasConceptScore W2957059501C176947019 @default.
- W2957059501 hasConceptScore W2957059501C190283241 @default.
- W2957059501 hasConceptScore W2957059501C2775934118 @default.
- W2957059501 hasConceptScore W2957059501C2776020440 @default.
- W2957059501 hasConceptScore W2957059501C2780950330 @default.
- W2957059501 hasConceptScore W2957059501C31573885 @default.
- W2957059501 hasConceptScore W2957059501C4937899 @default.
- W2957059501 hasConceptScore W2957059501C523546767 @default.
- W2957059501 hasConceptScore W2957059501C54355233 @default.
- W2957059501 hasConceptScore W2957059501C55493867 @default.
- W2957059501 hasConceptScore W2957059501C58123911 @default.
- W2957059501 hasConceptScore W2957059501C86803240 @default.
- W2957059501 hasConceptScore W2957059501C89423630 @default.
- W2957059501 hasIssue "10" @default.
- W2957059501 hasLocation W29570595011 @default.