Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957091024> ?p ?o ?g. }
- W2957091024 abstract "Plant lectins represent a major group of anti-nutritional factors that can be toxic to human and animals. However, the mechanisms by which lectins regulate cell fates are not well understood. In the present study, the cellular and molecular impacts of three common lectins, agglutinins from wheat germ [WGA (wheat germ agglutinin)], soybean [soybean agglutinin (SBA)] and peanut [peanut agglutinin (PNA)] were examined in zebrafish embryo and liver cells. WGA and SBA were found to induce cell apoptosis both in vitro and in vivo, while PNA stimulated cell proliferation. WGA and SBA reduced levels of B cell lymphoma-2 (Bcl-2), phosphorylation of Bcl-2-associated death promoter (Bad), cyclin-dependent kinase 4 (Cdk4), and phosphorylation of the retinoblastoma (Rb). WGA and SBA also inhibited the activities of cell survival pathways including protein kinase B (Akt), extracellular signal-regulated protein kinases 1 and 2 (Erk1/2), and target of rapamycin (Tor). Furthermore, WGA and SBA shifted the cellular metabolism characterized by reduced expression of glucose-6-phosphate dehydrogenase (g6pd) and increased expression of glutamine synthetase (glul) and glutamate dehydrogenase (glud). However, PNA showed the opposite effects toward these molecular markers compared to those of WGA and SBA. Therefore, our results revealed some plant lectins (WGA and SBA) were toxic while the other (PNA) was mitogenic. Further characterization of the distinct functions of individual lectins should be valuable for both nutrition and other potential applications." @default.
- W2957091024 created "2019-07-23" @default.
- W2957091024 creator A5002551083 @default.
- W2957091024 creator A5054579471 @default.
- W2957091024 creator A5056037038 @default.
- W2957091024 creator A5067213954 @default.
- W2957091024 creator A5071122162 @default.
- W2957091024 creator A5072967834 @default.
- W2957091024 creator A5090854541 @default.
- W2957091024 date "2019-06-05" @default.
- W2957091024 modified "2023-10-15" @default.
- W2957091024 title "Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish" @default.
- W2957091024 cites W102200185 @default.
- W2957091024 cites W1600051786 @default.
- W2957091024 cites W1608900606 @default.
- W2957091024 cites W1781143820 @default.
- W2957091024 cites W1804602290 @default.
- W2957091024 cites W1880804719 @default.
- W2957091024 cites W1972395581 @default.
- W2957091024 cites W1978851585 @default.
- W2957091024 cites W1980169213 @default.
- W2957091024 cites W1984865583 @default.
- W2957091024 cites W1987228708 @default.
- W2957091024 cites W1991199800 @default.
- W2957091024 cites W1998894959 @default.
- W2957091024 cites W2001708278 @default.
- W2957091024 cites W2002936220 @default.
- W2957091024 cites W2003252014 @default.
- W2957091024 cites W2007114641 @default.
- W2957091024 cites W2011265605 @default.
- W2957091024 cites W2012080407 @default.
- W2957091024 cites W2014140867 @default.
- W2957091024 cites W2016985488 @default.
- W2957091024 cites W2019896163 @default.
- W2957091024 cites W2020153062 @default.
- W2957091024 cites W2020392546 @default.
- W2957091024 cites W2020843603 @default.
- W2957091024 cites W2020987391 @default.
- W2957091024 cites W2024113857 @default.
- W2957091024 cites W2026061487 @default.
- W2957091024 cites W2033433765 @default.
- W2957091024 cites W2033981619 @default.
- W2957091024 cites W2038758713 @default.
- W2957091024 cites W2052121783 @default.
- W2957091024 cites W2056249715 @default.
- W2957091024 cites W2056389789 @default.
- W2957091024 cites W2058996003 @default.
- W2957091024 cites W2070862399 @default.
- W2957091024 cites W2073996554 @default.
- W2957091024 cites W2079260045 @default.
- W2957091024 cites W2082312713 @default.
- W2957091024 cites W2082992597 @default.
- W2957091024 cites W2087531955 @default.
- W2957091024 cites W2094755617 @default.
- W2957091024 cites W2097767970 @default.
- W2957091024 cites W2099343833 @default.
- W2957091024 cites W2103443262 @default.
- W2957091024 cites W2105073777 @default.
- W2957091024 cites W2105816476 @default.
- W2957091024 cites W2106441005 @default.
- W2957091024 cites W2107277218 @default.
- W2957091024 cites W2113938371 @default.
- W2957091024 cites W2117085811 @default.
- W2957091024 cites W2125349610 @default.
- W2957091024 cites W2127063807 @default.
- W2957091024 cites W2132629895 @default.
- W2957091024 cites W2142164571 @default.
- W2957091024 cites W2157650174 @default.
- W2957091024 cites W2158035115 @default.
- W2957091024 cites W2159882241 @default.
- W2957091024 cites W2169740379 @default.
- W2957091024 cites W2192080449 @default.
- W2957091024 cites W2311283174 @default.
- W2957091024 cites W2344695401 @default.
- W2957091024 cites W2480295750 @default.
- W2957091024 cites W2510435007 @default.
- W2957091024 cites W2591784895 @default.
- W2957091024 cites W2607815597 @default.
- W2957091024 cites W2739949590 @default.
- W2957091024 cites W2748924223 @default.
- W2957091024 cites W27614388 @default.
- W2957091024 cites W2766300799 @default.
- W2957091024 cites W2793830223 @default.
- W2957091024 doi "https://doi.org/10.3389/fendo.2019.00356" @default.
- W2957091024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6560201" @default.
- W2957091024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31231312" @default.
- W2957091024 hasPublicationYear "2019" @default.
- W2957091024 type Work @default.
- W2957091024 sameAs 2957091024 @default.
- W2957091024 citedByCount "9" @default.
- W2957091024 countsByYear W29570910242019 @default.
- W2957091024 countsByYear W29570910242020 @default.
- W2957091024 countsByYear W29570910242021 @default.
- W2957091024 countsByYear W29570910242022 @default.
- W2957091024 countsByYear W29570910242023 @default.
- W2957091024 crossrefType "journal-article" @default.
- W2957091024 hasAuthorship W2957091024A5002551083 @default.
- W2957091024 hasAuthorship W2957091024A5054579471 @default.
- W2957091024 hasAuthorship W2957091024A5056037038 @default.
- W2957091024 hasAuthorship W2957091024A5067213954 @default.