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• W2957093500 abstract "Abstract Experimentally measured residual dipolar couplings (RDCs) are highly valuable for atomic‐resolution structural and dynamic studies of molecular systems ranging from small molecules to large proteins by solution NMR spectroscopy. Here we demonstrate the first use of magnetic‐alignment behavior of lyotropic liquid‐crystalline polymer macro‐nanodiscs (>20 nm in diameter) as a novel alignment medium for the measurement of RDCs using high‐resolution NMR. The easy preparation of macro‐nanodiscs, their high stability against pH changes and the presence of divalent metal ions, and their high homogeneity make them an efficient tool to investigate a wide range of molecular systems including natural products, proteins, and RNA." @default.
• W2957093500 created "2019-07-23" @default.
• W2957093500 creator A5006414766 @default.
• W2957093500 creator A5075684983 @default.
• W2957093500 date "2019-09-11" @default.
• W2957093500 modified "2023-10-05" @default.
• W2957093500 title "Magnetic Alignment of Polymer Macro‐Nanodiscs Enables Residual‐Dipolar‐Coupling‐Based High‐Resolution Structural Studies by NMR Spectroscopy" @default.
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• W2957093500 doi "https://doi.org/10.1002/anie.201907655" @default.
• W2957093500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7161179" @default.
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