FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957095666> ?p ?o ?g. }

• W2957095666 abstract "Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone and dexamethasone, each delivered as crystalline suspensions to guinea pigs. Triamcinolone-acetonide is a widely used form of the drug with molecular properties that allow it to readily permeate biological barriers. When applied intratympanically triamcinolone-acetonide entered perilymph rapidly but was also found to be eliminated rapidly from perilymph. The rapid rate of elimination severely limits the apical distribution of the drug when applied locally, making it unsuitable for use in the ear. In contrast, triamcinolone, rather than triamcinolone-acetonide, is a more polar form of the molecule, with higher aqueous solubility but calculated to pass less-readily through biological boundaries. Perilymph concentrations generated with intratympanic applications of triamcinolone were comparable to those with triamcinolone-acetonide but elimination measurements showed that triamcinolone was retained in perilymph longer than triamcinolone-acetonide or dexamethasone. The slower elimination is projected to result in improved distribution of triamcinolone towards the cochlear apex, potentially allowing higher drug levels to reach the speech frequency regions of the human ear. These measurements show that triamcinolone could constitute an attractive additional treatment option for local therapy of auditory disorders." @default.
• W2957095666 created "2019-07-23" @default.
• W2957095666 creator A5010747298 @default.
• W2957095666 creator A5036650914 @default.
• W2957095666 creator A5074796325 @default.
• W2957095666 creator A5076918693 @default.
• W2957095666 date "2019-07-30" @default.
• W2957095666 modified "2023-10-16" @default.
• W2957095666 title "Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear" @default.
• W2957095666 cites W1490995508 @default.
• W2957095666 cites W1521361967 @default.
• W2957095666 cites W1622582222 @default.
• W2957095666 cites W1969958607 @default.
• W2957095666 cites W1970864641 @default.
• W2957095666 cites W2007331949 @default.
• W2957095666 cites W2010542741 @default.
• W2957095666 cites W2011505858 @default.
• W2957095666 cites W2019753501 @default.
• W2957095666 cites W2028808636 @default.
• W2957095666 cites W2030877917 @default.
• W2957095666 cites W2047465917 @default.
• W2957095666 cites W2053543989 @default.
• W2957095666 cites W2055217634 @default.
• W2957095666 cites W2058913110 @default.
• W2957095666 cites W2069047687 @default.
• W2957095666 cites W2076547530 @default.
• W2957095666 cites W2081453354 @default.
• W2957095666 cites W2091842142 @default.
• W2957095666 cites W2098881307 @default.
• W2957095666 cites W2102136926 @default.
• W2957095666 cites W2113453890 @default.
• W2957095666 cites W2137014027 @default.
• W2957095666 cites W2157854297 @default.
• W2957095666 cites W2165066266 @default.
• W2957095666 cites W2396930286 @default.
• W2957095666 cites W2404519752 @default.
• W2957095666 cites W2528544256 @default.
• W2957095666 cites W2535900900 @default.
• W2957095666 cites W2571152266 @default.
• W2957095666 cites W2593436234 @default.
• W2957095666 cites W2606894281 @default.
• W2957095666 cites W2776543576 @default.
• W2957095666 cites W2796717499 @default.
• W2957095666 cites W2903300664 @default.
• W2957095666 cites W2952526490 @default.
• W2957095666 doi "https://doi.org/10.3389/fncel.2019.00347" @default.
• W2957095666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6689996" @default.
• W2957095666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31427927" @default.
• W2957095666 hasPublicationYear "2019" @default.
• W2957095666 type Work @default.
• W2957095666 sameAs 2957095666 @default.
• W2957095666 citedByCount "20" @default.
• W2957095666 countsByYear W29570956662020 @default.
• W2957095666 countsByYear W29570956662021 @default.
• W2957095666 countsByYear W29570956662022 @default.
• W2957095666 countsByYear W29570956662023 @default.
• W2957095666 crossrefType "journal-article" @default.
• W2957095666 hasAuthorship W2957095666A5010747298 @default.
• W2957095666 hasAuthorship W2957095666A5036650914 @default.
• W2957095666 hasAuthorship W2957095666A5074796325 @default.
• W2957095666 hasAuthorship W2957095666A5076918693 @default.
• W2957095666 hasBestOaLocation W29570956661 @default.
• W2957095666 hasConcept C105702510 @default.
• W2957095666 hasConcept C112705442 @default.
• W2957095666 hasConcept C118487528 @default.
• W2957095666 hasConcept C126322002 @default.
• W2957095666 hasConcept C185592680 @default.
• W2957095666 hasConcept C2778317342 @default.
• W2957095666 hasConcept C2778500370 @default.
• W2957095666 hasConcept C2778903070 @default.
• W2957095666 hasConcept C2780401358 @default.
• W2957095666 hasConcept C71924100 @default.
• W2957095666 hasConcept C98274493 @default.
• W2957095666 hasConceptScore W2957095666C105702510 @default.
• W2957095666 hasConceptScore W2957095666C112705442 @default.
• W2957095666 hasConceptScore W2957095666C118487528 @default.
• W2957095666 hasConceptScore W2957095666C126322002 @default.
• W2957095666 hasConceptScore W2957095666C185592680 @default.
• W2957095666 hasConceptScore W2957095666C2778317342 @default.
• W2957095666 hasConceptScore W2957095666C2778500370 @default.
• W2957095666 hasConceptScore W2957095666C2778903070 @default.
• W2957095666 hasConceptScore W2957095666C2780401358 @default.
• W2957095666 hasConceptScore W2957095666C71924100 @default.
• W2957095666 hasConceptScore W2957095666C98274493 @default.
• W2957095666 hasLocation W29570956661 @default.
• W2957095666 hasLocation W29570956662 @default.
• W2957095666 hasLocation W29570956663 @default.
• W2957095666 hasLocation W29570956664 @default.
• W2957095666 hasLocation W29570956665 @default.
• W2957095666 hasOpenAccess W2957095666 @default.
• W2957095666 hasPrimaryLocation W29570956661 @default.
• W2957095666 hasRelatedWork W2027955909 @default.
• W2957095666 hasRelatedWork W2084293647 @default.
• W2957095666 hasRelatedWork W2095400867 @default.
• W2957095666 hasRelatedWork W2413190828 @default.
• W2957095666 hasRelatedWork W2432171985 @default.
• W2957095666 hasRelatedWork W2776543576 @default.
• W2957095666 hasRelatedWork W3202221519 @default.
• W2957095666 hasRelatedWork W4205476023 @default.
• W2957095666 hasRelatedWork W4225805713 @default.

• next