FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957100429> ?p ?o ?g. }

• W2957100429 endingPage "290" @default.
• W2957100429 startingPage "284" @default.
• W2957100429 abstract "Discrimination between sensory stimuli associated with safety and threat is crucial for behavioral decisions. Discriminative conditioning paradigms with two acoustic conditioned stimuli (one paired with shock [CS+], the other unpaired with shock [CS−]) have been widely used as an experimental model for fear learning. However, no attention has been paid to the effect of the CS− on safety in the paradigms, because the CS− served as a neutral cue or elevated the freezing level due to fear generalization although less effectively than the CS+. By using a noise and a tone as two acoustic CSs in a discriminative auditory fear conditioning (AFC) paradigm, here we demonstrate that mice learn safety for the CS− while showing fear for the CS+ with opposing emotional behaviors. We found that after learning mice exhibited a significant suppression of context-dependent freezing during the CS−, but not during the CS+, indicating learned safety without fear generalization for the CS−. In contrast, the mice showed an enhanced level of freezing during the CS+ even in a novel spatial context, indicating cued fear for the CS+. Moreover, the CS+ also induced rapid defensive behaviors, whereas the CS− disinhibited normal exploratory behaviors. On the other hand, mice showed no significant suppression of contextual fear during the CS− in a paradigm with a pair of tone CSs at different frequencies, although they clearly discriminated the two tones. These results suggest our AFC paradigm with the noise and tone CSs as a useful experimental model for cue-dependent discriminative learning of safety and threat." @default.
• W2957100429 created "2019-07-23" @default.
• W2957100429 creator A5052661219 @default.
• W2957100429 creator A5063053004 @default.
• W2957100429 date "2019-07-15" @default.
• W2957100429 modified "2023-10-18" @default.
• W2957100429 title "Cue-dependent safety and fear learning in a discriminative auditory fear conditioning paradigm in the mouse" @default.
• W2957100429 cites W1964527618 @default.
• W2957100429 cites W1969998870 @default.
• W2957100429 cites W1977683656 @default.
• W2957100429 cites W1977988769 @default.
• W2957100429 cites W1986764547 @default.
• W2957100429 cites W1990351105 @default.
• W2957100429 cites W1995689771 @default.
• W2957100429 cites W2005835243 @default.
• W2957100429 cites W2012159547 @default.
• W2957100429 cites W2015067996 @default.
• W2957100429 cites W2020902468 @default.
• W2957100429 cites W2024365408 @default.
• W2957100429 cites W2031142338 @default.
• W2957100429 cites W2034288991 @default.
• W2957100429 cites W2034377987 @default.
• W2957100429 cites W2039641259 @default.
• W2957100429 cites W2041469451 @default.
• W2957100429 cites W2042592150 @default.
• W2957100429 cites W2044686824 @default.
• W2957100429 cites W2047702351 @default.
• W2957100429 cites W2049583465 @default.
• W2957100429 cites W2066642195 @default.
• W2957100429 cites W2082912956 @default.
• W2957100429 cites W2087082832 @default.
• W2957100429 cites W2103704610 @default.
• W2957100429 cites W2110747672 @default.
• W2957100429 cites W2128472904 @default.
• W2957100429 cites W2138006810 @default.
• W2957100429 cites W2144242982 @default.
• W2957100429 cites W2157081213 @default.
• W2957100429 cites W2517749259 @default.
• W2957100429 cites W2565268464 @default.
• W2957100429 cites W2770009543 @default.
• W2957100429 cites W2893713403 @default.
• W2957100429 doi "https://doi.org/10.1101/lm.049577.119" @default.
• W2957100429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6636544" @default.
• W2957100429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31308247" @default.
• W2957100429 hasPublicationYear "2019" @default.
• W2957100429 type Work @default.
• W2957100429 sameAs 2957100429 @default.
• W2957100429 citedByCount "7" @default.
• W2957100429 countsByYear W29571004292019 @default.
• W2957100429 countsByYear W29571004292021 @default.
• W2957100429 countsByYear W29571004292022 @default.
• W2957100429 countsByYear W29571004292023 @default.
• W2957100429 crossrefType "journal-article" @default.
• W2957100429 hasAuthorship W2957100429A5052661219 @default.
• W2957100429 hasAuthorship W2957100429A5063053004 @default.
• W2957100429 hasBestOaLocation W29571004291 @default.
• W2957100429 hasConcept C105795698 @default.
• W2957100429 hasConcept C124952713 @default.
• W2957100429 hasConcept C134306372 @default.
• W2957100429 hasConcept C142362112 @default.
• W2957100429 hasConcept C151730666 @default.
• W2957100429 hasConcept C15744967 @default.
• W2957100429 hasConcept C16837860 @default.
• W2957100429 hasConcept C169760540 @default.
• W2957100429 hasConcept C177148314 @default.
• W2957100429 hasConcept C180747234 @default.
• W2957100429 hasConcept C2779144063 @default.
• W2957100429 hasConcept C2779343474 @default.
• W2957100429 hasConcept C2780583480 @default.
• W2957100429 hasConcept C2781069985 @default.
• W2957100429 hasConcept C33923547 @default.
• W2957100429 hasConcept C45262634 @default.
• W2957100429 hasConcept C548259974 @default.
• W2957100429 hasConcept C71924100 @default.
• W2957100429 hasConcept C86803240 @default.
• W2957100429 hasConceptScore W2957100429C105795698 @default.
• W2957100429 hasConceptScore W2957100429C124952713 @default.
• W2957100429 hasConceptScore W2957100429C134306372 @default.
• W2957100429 hasConceptScore W2957100429C142362112 @default.
• W2957100429 hasConceptScore W2957100429C151730666 @default.
• W2957100429 hasConceptScore W2957100429C15744967 @default.
• W2957100429 hasConceptScore W2957100429C16837860 @default.
• W2957100429 hasConceptScore W2957100429C169760540 @default.
• W2957100429 hasConceptScore W2957100429C177148314 @default.
• W2957100429 hasConceptScore W2957100429C180747234 @default.
• W2957100429 hasConceptScore W2957100429C2779144063 @default.
• W2957100429 hasConceptScore W2957100429C2779343474 @default.
• W2957100429 hasConceptScore W2957100429C2780583480 @default.
• W2957100429 hasConceptScore W2957100429C2781069985 @default.
• W2957100429 hasConceptScore W2957100429C33923547 @default.
• W2957100429 hasConceptScore W2957100429C45262634 @default.
• W2957100429 hasConceptScore W2957100429C548259974 @default.
• W2957100429 hasConceptScore W2957100429C71924100 @default.
• W2957100429 hasConceptScore W2957100429C86803240 @default.
• W2957100429 hasFunder F4320334764 @default.
• W2957100429 hasIssue "8" @default.
• W2957100429 hasLocation W29571004291 @default.
• W2957100429 hasLocation W29571004292 @default.

• next