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• W2957135655 abstract "Background and aim: Loss of p53 function has been suggested to be a critical step inmultistage hepatocarcinogenesis. So, we aimed to investigate the frequency of P53codon 72 gene polymorphism and its relation to plasma P53 levels in Egyptianpatients with hepatocellular carcinoma (HCC) on top of viral and nonviral etiologies.Methods: This is a hospital-based case-control study which included 159 HCCpatients in addition to 83 healthy volunteers as controls. Patients were classified into:63 patients with HCC complicating cirrhosis due to HCV; 55 patients with HCCcomplicating cirrhosis due to HBV and 41 patients with HCC complicating cirrhosisdue to nonviral causes. Quantitative determination of plasma P53 levels wasperformed by ELISA. P53 Arg 72 Pro gene polymorphism was carried out byconventional PCR followed by restriction enzyme digestion (PCR-RFLP). Results:There were significant increases in α.fetoprotein and plasma P53 levels in all studiedgroups in relation to the control group. AA genotype and A allele were more in thecontrol group, PP genotype and P allele were more frequent in HCV related HCCgroup & HCC with non viral causes. AP genotype and P allele were more frequent inHBV related HCC group. P 53 plasma level showed significant increase in all groupsin relation to the control group in AA genotype, AP genotype and PP genotype. Therewere significant increases in AP and PP genotype in all studied groups in comparisonto AA genotype. Plasma P53 level showed significant increase in all groups in bothallele A and allele P when compared with the control group. Also, it showedsignificant increase in their levels in P allele when compared with that of A allele inall studied groups. Conclusion: plasma p53 protein level could be considered as anadditional tumor marker to AFP to increase the diagnostic potential of AFP in HCCpatients. Therefore, P53codon 72 gene polymorphism could be used as an indicatorof the genetic susceptibility for future development of HCC in Egyptian cirrhoticpatients." @default.
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• W2957135655 date "2012-12-01" @default.
• W2957135655 modified "2023-09-24" @default.
• W2957135655 title "P53 Codon 72 Gene Polymorphism in Patients with Hepatocellular Carcinoma on Top of Viral and Nonviral Etiologies" @default.
• W2957135655 cites W1486860736 @default.
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• W2957135655 doi "https://doi.org/10.21608/besps.2012.35838" @default.
• W2957135655 hasPublicationYear "2012" @default.
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