Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957263560> ?p ?o ?g. }
- W2957263560 endingPage "794" @default.
- W2957263560 startingPage "784" @default.
- W2957263560 abstract "In this study, we prepared polydopamine-gelatin templated electrospun nanofibers, which were coated with precisely controlled amounts of biominerals in the form of simulated body fluid (SBF). We initially investigated the effects of different mineral concentrations on the in vitro osteogenic differentiation of human adipose derived stem cells (hADSCs), demonstrating the increase in osteogenic differentiation as a function of mineral concentration without any osteogenic supplements. Meanwhile, in the presence of chondrogenic medium, nanofibers with lower mineral contents showed the highest chondrogenic commitment of hADSCs, while more highly mineralized samples greatly inhibited chondrogenesis. We then generated a mineral gradient on the nanofiber surface and examined the hADSC responses under different media conditions. The hADSCs showed a gradient osteoblast phenotype on a mineral gradient of nanofibers under growth media conditions. Under chondrogenic media conditions, hADSCs favored osteogenic differentiation in the more mineralized positions, while lower mineral content induced chondrogenic differentiation of the hADSCs, consistent with the trend in nanofibers with different mineral contents. These results suggest that the controlled presentation of minerals on the material substrate in combination with soluble inducing factors could be used as a tool for stem cell-based osteochondral tissue engineering." @default.
- W2957263560 created "2019-07-23" @default.
- W2957263560 creator A5046146264 @default.
- W2957263560 creator A5050008313 @default.
- W2957263560 creator A5062317501 @default.
- W2957263560 creator A5072397615 @default.
- W2957263560 creator A5085614043 @default.
- W2957263560 date "2019-12-01" @default.
- W2957263560 modified "2023-10-15" @default.
- W2957263560 title "Effect of gradient biomineral concentrations on osteogenic and chondrogenic differentiation of adipose derived stem cells" @default.
- W2957263560 cites W1503245938 @default.
- W2957263560 cites W1929517245 @default.
- W2957263560 cites W1965312450 @default.
- W2957263560 cites W1968101546 @default.
- W2957263560 cites W1973043293 @default.
- W2957263560 cites W1978424120 @default.
- W2957263560 cites W1980881554 @default.
- W2957263560 cites W1981495500 @default.
- W2957263560 cites W1983392170 @default.
- W2957263560 cites W1983787345 @default.
- W2957263560 cites W1987422872 @default.
- W2957263560 cites W2012119502 @default.
- W2957263560 cites W2018593634 @default.
- W2957263560 cites W2018957920 @default.
- W2957263560 cites W2026571103 @default.
- W2957263560 cites W2034244937 @default.
- W2957263560 cites W2037810763 @default.
- W2957263560 cites W2038120349 @default.
- W2957263560 cites W2038641983 @default.
- W2957263560 cites W2042065329 @default.
- W2957263560 cites W2059421614 @default.
- W2957263560 cites W2063261010 @default.
- W2957263560 cites W2065008385 @default.
- W2957263560 cites W2067248665 @default.
- W2957263560 cites W2086903479 @default.
- W2957263560 cites W2092858957 @default.
- W2957263560 cites W2103011143 @default.
- W2957263560 cites W2124349212 @default.
- W2957263560 cites W2132774797 @default.
- W2957263560 cites W2134208433 @default.
- W2957263560 cites W2190386353 @default.
- W2957263560 cites W2295917582 @default.
- W2957263560 cites W2302348915 @default.
- W2957263560 cites W2332489550 @default.
- W2957263560 cites W2338603586 @default.
- W2957263560 cites W2402255418 @default.
- W2957263560 cites W2434412871 @default.
- W2957263560 cites W2563869327 @default.
- W2957263560 cites W2611648844 @default.
- W2957263560 cites W2776174326 @default.
- W2957263560 cites W2790090456 @default.
- W2957263560 cites W749367669 @default.
- W2957263560 doi "https://doi.org/10.1016/j.jiec.2019.06.037" @default.
- W2957263560 hasPublicationYear "2019" @default.
- W2957263560 type Work @default.
- W2957263560 sameAs 2957263560 @default.
- W2957263560 citedByCount "10" @default.
- W2957263560 countsByYear W29572635602020 @default.
- W2957263560 countsByYear W29572635602021 @default.
- W2957263560 countsByYear W29572635602022 @default.
- W2957263560 countsByYear W29572635602023 @default.
- W2957263560 crossrefType "journal-article" @default.
- W2957263560 hasAuthorship W2957263560A5046146264 @default.
- W2957263560 hasAuthorship W2957263560A5050008313 @default.
- W2957263560 hasAuthorship W2957263560A5062317501 @default.
- W2957263560 hasAuthorship W2957263560A5072397615 @default.
- W2957263560 hasAuthorship W2957263560A5085614043 @default.
- W2957263560 hasConcept C12554922 @default.
- W2957263560 hasConcept C136229726 @default.
- W2957263560 hasConcept C171089720 @default.
- W2957263560 hasConcept C171250308 @default.
- W2957263560 hasConcept C185592680 @default.
- W2957263560 hasConcept C192562407 @default.
- W2957263560 hasConcept C198826908 @default.
- W2957263560 hasConcept C202751555 @default.
- W2957263560 hasConcept C2778260815 @default.
- W2957263560 hasConcept C35496256 @default.
- W2957263560 hasConcept C49892992 @default.
- W2957263560 hasConcept C55493867 @default.
- W2957263560 hasConcept C71924100 @default.
- W2957263560 hasConcept C86803240 @default.
- W2957263560 hasConcept C91129048 @default.
- W2957263560 hasConcept C95444343 @default.
- W2957263560 hasConceptScore W2957263560C12554922 @default.
- W2957263560 hasConceptScore W2957263560C136229726 @default.
- W2957263560 hasConceptScore W2957263560C171089720 @default.
- W2957263560 hasConceptScore W2957263560C171250308 @default.
- W2957263560 hasConceptScore W2957263560C185592680 @default.
- W2957263560 hasConceptScore W2957263560C192562407 @default.
- W2957263560 hasConceptScore W2957263560C198826908 @default.
- W2957263560 hasConceptScore W2957263560C202751555 @default.
- W2957263560 hasConceptScore W2957263560C2778260815 @default.
- W2957263560 hasConceptScore W2957263560C35496256 @default.
- W2957263560 hasConceptScore W2957263560C49892992 @default.
- W2957263560 hasConceptScore W2957263560C55493867 @default.
- W2957263560 hasConceptScore W2957263560C71924100 @default.
- W2957263560 hasConceptScore W2957263560C86803240 @default.
- W2957263560 hasConceptScore W2957263560C91129048 @default.