Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957343169> ?p ?o ?g. }
- W2957343169 abstract "Abstract Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expressing the multi-drug efflux transporter ABCB1. ABCB1 gene expression was observed in 4 out of 5 paediatric ependymoma cell lines and increased in stem cell enriched neurospheres. Functional inhibition of ABCB1 using vardenafil or verapamil significantly (p ≤ 0.05–0.001) potentiated the response to three chemotherapeutic drugs (vincristine, etoposide and methotrexate). Both inhibitors were also able to significantly reduce migration (p ≤ 0.001) and invasion (p ≤ 0.001). We demonstrate that ABCB1 positive patients from an infant chemotherapy-led trial (CNS9204) had a shorter mean event free survival (EFS) (2.7 versus 8.6 years; p = 0.007 log-rank analysis) and overall survival (OS) (5.4 versus 12 years; p = 0.009 log-rank analysis). ABCB1 positivity also correlated with reduced event free survival in patients with incompletely resected tumours who received chemotherapy across CNS9204 and CNS9904 (a radiotherapy-led SIOP 1999-04 trial cohort; p = 0.03). ABCB1 is a predictive marker of chemotherapy response in ependymoma patients and vardenafil, currently used to treat paediatric pulmonary hypertension in children, could be repurposed to reduce chemoresistance, migration and invasion in paediatric ependymoma patients at non-toxic concentrations." @default.
- W2957343169 created "2019-07-23" @default.
- W2957343169 creator A5008298393 @default.
- W2957343169 creator A5030304082 @default.
- W2957343169 creator A5049103395 @default.
- W2957343169 creator A5050653303 @default.
- W2957343169 creator A5060875428 @default.
- W2957343169 creator A5065438005 @default.
- W2957343169 creator A5073293416 @default.
- W2957343169 creator A5081980770 @default.
- W2957343169 date "2019-07-16" @default.
- W2957343169 modified "2023-10-13" @default.
- W2957343169 title "A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma" @default.
- W2957343169 cites W1932702231 @default.
- W2957343169 cites W1938258468 @default.
- W2957343169 cites W1941346671 @default.
- W2957343169 cites W1949037014 @default.
- W2957343169 cites W1964339879 @default.
- W2957343169 cites W1966188377 @default.
- W2957343169 cites W1971349026 @default.
- W2957343169 cites W1976979641 @default.
- W2957343169 cites W1980714336 @default.
- W2957343169 cites W1982352657 @default.
- W2957343169 cites W1995571828 @default.
- W2957343169 cites W2008123285 @default.
- W2957343169 cites W2020277292 @default.
- W2957343169 cites W2020537893 @default.
- W2957343169 cites W2027313027 @default.
- W2957343169 cites W2040006430 @default.
- W2957343169 cites W2041044820 @default.
- W2957343169 cites W2055904567 @default.
- W2957343169 cites W2061269419 @default.
- W2957343169 cites W2062069198 @default.
- W2957343169 cites W2065456444 @default.
- W2957343169 cites W2068193990 @default.
- W2957343169 cites W2086195681 @default.
- W2957343169 cites W2086737570 @default.
- W2957343169 cites W2100592123 @default.
- W2957343169 cites W2107277218 @default.
- W2957343169 cites W2112309180 @default.
- W2957343169 cites W2123759275 @default.
- W2957343169 cites W2124482905 @default.
- W2957343169 cites W2127507403 @default.
- W2957343169 cites W2136949790 @default.
- W2957343169 cites W2147051337 @default.
- W2957343169 cites W2150997246 @default.
- W2957343169 cites W2160619817 @default.
- W2957343169 cites W2162655420 @default.
- W2957343169 cites W2162695324 @default.
- W2957343169 cites W2318212267 @default.
- W2957343169 cites W2403633080 @default.
- W2957343169 cites W4245392732 @default.
- W2957343169 doi "https://doi.org/10.1038/s41598-019-46700-z" @default.
- W2957343169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6635358" @default.
- W2957343169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31311995" @default.
- W2957343169 hasPublicationYear "2019" @default.
- W2957343169 type Work @default.
- W2957343169 sameAs 2957343169 @default.
- W2957343169 citedByCount "12" @default.
- W2957343169 countsByYear W29573431692020 @default.
- W2957343169 countsByYear W29573431692021 @default.
- W2957343169 countsByYear W29573431692022 @default.
- W2957343169 countsByYear W29573431692023 @default.
- W2957343169 crossrefType "journal-article" @default.
- W2957343169 hasAuthorship W2957343169A5008298393 @default.
- W2957343169 hasAuthorship W2957343169A5030304082 @default.
- W2957343169 hasAuthorship W2957343169A5049103395 @default.
- W2957343169 hasAuthorship W2957343169A5050653303 @default.
- W2957343169 hasAuthorship W2957343169A5060875428 @default.
- W2957343169 hasAuthorship W2957343169A5065438005 @default.
- W2957343169 hasAuthorship W2957343169A5073293416 @default.
- W2957343169 hasAuthorship W2957343169A5081980770 @default.
- W2957343169 hasBestOaLocation W29573431691 @default.
- W2957343169 hasConcept C114851261 @default.
- W2957343169 hasConcept C126322002 @default.
- W2957343169 hasConcept C141071460 @default.
- W2957343169 hasConcept C143998085 @default.
- W2957343169 hasConcept C2776694085 @default.
- W2957343169 hasConcept C2776755627 @default.
- W2957343169 hasConcept C2778119113 @default.
- W2957343169 hasConcept C2779429289 @default.
- W2957343169 hasConcept C2781303535 @default.
- W2957343169 hasConcept C2781432949 @default.
- W2957343169 hasConcept C2908647359 @default.
- W2957343169 hasConcept C71924100 @default.
- W2957343169 hasConcept C86803240 @default.
- W2957343169 hasConcept C89423630 @default.
- W2957343169 hasConcept C99454951 @default.
- W2957343169 hasConceptScore W2957343169C114851261 @default.
- W2957343169 hasConceptScore W2957343169C126322002 @default.
- W2957343169 hasConceptScore W2957343169C141071460 @default.
- W2957343169 hasConceptScore W2957343169C143998085 @default.
- W2957343169 hasConceptScore W2957343169C2776694085 @default.
- W2957343169 hasConceptScore W2957343169C2776755627 @default.
- W2957343169 hasConceptScore W2957343169C2778119113 @default.
- W2957343169 hasConceptScore W2957343169C2779429289 @default.
- W2957343169 hasConceptScore W2957343169C2781303535 @default.
- W2957343169 hasConceptScore W2957343169C2781432949 @default.
- W2957343169 hasConceptScore W2957343169C2908647359 @default.
- W2957343169 hasConceptScore W2957343169C71924100 @default.