FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957371100> ?p ?o ?g. }

• W2957371100 endingPage "420" @default.
• W2957371100 startingPage "411" @default.
• W2957371100 abstract "Pharmaceutical excipients in drug products are defined as pharmacologically inactive and are integral constituents of all types of oral dosage forms. However, some excipients may increase drug absorption by interacting with the mucosal membrane. If the strategy is to use an excipient with a potential to affect the processes determining the rate and/or extent of the intestinal drug absorption, it is defined as an absorption-modifying excipients (AME). These pharmaceutical excipients may act as AMEs, depending on the amounts applied, and accordingly influence bioequivalence assessment of innovative and generic drug products, as well as enable oral delivery of peptides and oligonucleotides. This review discusses the mechanisms by which AMEs increase drug absorption, and especially permeation step. The focus is on the most recent data regarding how AMEs can be evaluated in preclinical models, with an emphasis on in situ and in vivo intestinal absorption models. The in vivo predictive value of these models is reviewed for five factors of clinical relevance for the intestinal absorption performance: (a) effect and response rate of AMEs, (b) mucosal exposure time and intestinal transit of AMEs, (c) intraluminal AME dilution and prandial state, (d) mucosal recovery and safety, and (e) variability in the effects of the AMEs. We argue that any preclinical investigations of AMEs that fail to consider these processes will ultimately be of limited clinical value and add little to our understanding of how excipients affect intestinal drug absorption." @default.
• W2957371100 created "2019-07-23" @default.
• W2957371100 creator A5018759092 @default.
• W2957371100 creator A5025820069 @default.
• W2957371100 creator A5088832801 @default.
• W2957371100 date "2019-09-01" @default.
• W2957371100 modified "2023-10-01" @default.
• W2957371100 title "Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations" @default.
• W2957371100 cites W134089957 @default.
• W2957371100 cites W1498305210 @default.
• W2957371100 cites W1501546570 @default.
• W2957371100 cites W1506242946 @default.
• W2957371100 cites W1512892209 @default.
• W2957371100 cites W1529857113 @default.
• W2957371100 cites W156207140 @default.
• W2957371100 cites W1568216484 @default.
• W2957371100 cites W1588854391 @default.
• W2957371100 cites W1968154981 @default.
• W2957371100 cites W1971319971 @default.
• W2957371100 cites W1980405222 @default.
• W2957371100 cites W1981068608 @default.
• W2957371100 cites W1981367331 @default.
• W2957371100 cites W1986486038 @default.
• W2957371100 cites W1995111647 @default.
• W2957371100 cites W2000955852 @default.
• W2957371100 cites W2002200747 @default.
• W2957371100 cites W2003445994 @default.
• W2957371100 cites W2003859016 @default.
• W2957371100 cites W2007052092 @default.
• W2957371100 cites W2018815492 @default.
• W2957371100 cites W2028273867 @default.
• W2957371100 cites W2028654320 @default.
• W2957371100 cites W2031576029 @default.
• W2957371100 cites W2036181656 @default.
• W2957371100 cites W2038847837 @default.
• W2957371100 cites W2040426345 @default.
• W2957371100 cites W2050002385 @default.
• W2957371100 cites W2052157194 @default.
• W2957371100 cites W2060734180 @default.
• W2957371100 cites W2060917067 @default.
• W2957371100 cites W2062853793 @default.
• W2957371100 cites W2065226079 @default.
• W2957371100 cites W2065371215 @default.
• W2957371100 cites W2067451034 @default.
• W2957371100 cites W2070337781 @default.
• W2957371100 cites W2073430961 @default.
• W2957371100 cites W2079105723 @default.
• W2957371100 cites W2089151483 @default.
• W2957371100 cites W2091483354 @default.
• W2957371100 cites W2095179999 @default.
• W2957371100 cites W2100114021 @default.
• W2957371100 cites W2105682137 @default.
• W2957371100 cites W2111994809 @default.
• W2957371100 cites W2117939995 @default.
• W2957371100 cites W2126146585 @default.
• W2957371100 cites W2126738960 @default.
• W2957371100 cites W2140661985 @default.
• W2957371100 cites W2145189896 @default.
• W2957371100 cites W2146548337 @default.
• W2957371100 cites W2160190817 @default.
• W2957371100 cites W2165505209 @default.
• W2957371100 cites W2168866737 @default.
• W2957371100 cites W2284082872 @default.
• W2957371100 cites W2311757342 @default.
• W2957371100 cites W2313724273 @default.
• W2957371100 cites W2314903645 @default.
• W2957371100 cites W2337192313 @default.
• W2957371100 cites W2399692757 @default.
• W2957371100 cites W2433570839 @default.
• W2957371100 cites W2486949243 @default.
• W2957371100 cites W2487051368 @default.
• W2957371100 cites W2504854013 @default.
• W2957371100 cites W2515974008 @default.
• W2957371100 cites W2599428142 @default.
• W2957371100 cites W2736799665 @default.
• W2957371100 cites W2742025334 @default.
• W2957371100 cites W2755491718 @default.
• W2957371100 cites W2783888978 @default.
• W2957371100 cites W2793149067 @default.
• W2957371100 cites W2795688394 @default.
• W2957371100 cites W2802447939 @default.
• W2957371100 cites W2883284633 @default.
• W2957371100 cites W2888357119 @default.
• W2957371100 cites W2889029507 @default.
• W2957371100 cites W2893042312 @default.
• W2957371100 cites W2901306081 @default.
• W2957371100 cites W2910075131 @default.
• W2957371100 cites W320686992 @default.
• W2957371100 cites W4292328697 @default.
• W2957371100 doi "https://doi.org/10.1016/j.ejpb.2019.07.013" @default.
• W2957371100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31306749" @default.
• W2957371100 hasPublicationYear "2019" @default.
• W2957371100 type Work @default.
• W2957371100 sameAs 2957371100 @default.
• W2957371100 citedByCount "28" @default.
• W2957371100 countsByYear W29573711002020 @default.
• W2957371100 countsByYear W29573711002021 @default.
• W2957371100 countsByYear W29573711002022 @default.

• next