FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957404411> ?p ?o ?g. }

• W2957404411 abstract "Background Systemic iron status has been implicated in atherosclerosis and thrombosis. The aim of this study was to investigate the effect of genetically determined iron status on carotid intima‐media thickness, carotid plaque, and venous thromboembolism using Mendelian randomization. Methods and Results Genetic instrumental variables for iron status were selected from a genome‐wide meta‐analysis of 48 972 subjects. Genetic association estimates for carotid intima‐media thickness and carotid plaque were obtained using data from 71 128 and 48 434 participants, respectively, and estimates for venous thromboembolism were obtained using data from a study incorporating 7507 cases and 52 632 controls. Conventional 2‐sample summary data Mendelian randomization was performed for the main analysis. Higher genetically determined iron status was associated with increased risk of venous thromboembolism. Odds ratios per SD increase in biomarker levels were 1.37 (95% CI 1.14‐1.66) for serum iron, 1.25 (1.09‐1.43) for transferrin saturation, 1.92 (1.28‐2.88) for ferritin, and 0.76 (0.63‐0.92) for serum transferrin (with higher transferrin levels representing lower iron status). In contrast, higher iron status was associated with lower risk of carotid plaque. Corresponding odds ratios were 0.85 (0.73‐0.99) for serum iron and 0.89 (0.80‐1.00) for transferrin saturation, with concordant trends for serum transferrin and ferritin that did not reach statistical significance. There was no Mendelian randomization evidence of an effect of iron status on carotid intima‐media thickness. Conclusions These findings support previous work to suggest that higher genetically determined iron status is protective against some forms of atherosclerotic disease but increases the risk of thrombosis related to stasis of blood." @default.
• W2957404411 created "2019-07-23" @default.
• W2957404411 creator A5004946791 @default.
• W2957404411 creator A5029602994 @default.
• W2957404411 creator A5031686292 @default.
• W2957404411 creator A5050101545 @default.
• W2957404411 creator A5051921393 @default.
• W2957404411 creator A5054061856 @default.
• W2957404411 creator A5070950600 @default.
• W2957404411 creator A5081896930 @default.
• W2957404411 date "2019-08-06" @default.
• W2957404411 modified "2023-09-30" @default.
• W2957404411 title "Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study" @default.
• W2957404411 cites W1514292093 @default.
• W2957404411 cites W1548549814 @default.
• W2957404411 cites W1966776357 @default.
• W2957404411 cites W1969393140 @default.
• W2957404411 cites W1971506218 @default.
• W2957404411 cites W1972696558 @default.
• W2957404411 cites W1988557610 @default.
• W2957404411 cites W2002349652 @default.
• W2957404411 cites W2013710547 @default.
• W2957404411 cites W2021223658 @default.
• W2957404411 cites W2044293752 @default.
• W2957404411 cites W2047451215 @default.
• W2957404411 cites W2052622058 @default.
• W2957404411 cites W2056789496 @default.
• W2957404411 cites W2072364971 @default.
• W2957404411 cites W2096940418 @default.
• W2957404411 cites W2105391691 @default.
• W2957404411 cites W2107409683 @default.
• W2957404411 cites W2110519498 @default.
• W2957404411 cites W2113699335 @default.
• W2957404411 cites W2118008714 @default.
• W2957404411 cites W2121273469 @default.
• W2957404411 cites W2126500530 @default.
• W2957404411 cites W2127767012 @default.
• W2957404411 cites W2130376609 @default.
• W2957404411 cites W2130601361 @default.
• W2957404411 cites W2131601303 @default.
• W2957404411 cites W2133807501 @default.
• W2957404411 cites W2151034010 @default.
• W2957404411 cites W2151096860 @default.
• W2957404411 cites W2152302509 @default.
• W2957404411 cites W2153533315 @default.
• W2957404411 cites W2159509177 @default.
• W2957404411 cites W2159966247 @default.
• W2957404411 cites W2166218331 @default.
• W2957404411 cites W2196906371 @default.
• W2957404411 cites W2283881916 @default.
• W2957404411 cites W2324862792 @default.
• W2957404411 cites W2329922226 @default.
• W2957404411 cites W2344977044 @default.
• W2957404411 cites W2398025931 @default.
• W2957404411 cites W2520048741 @default.
• W2957404411 cites W2528302205 @default.
• W2957404411 cites W2604218568 @default.
• W2957404411 cites W2614566443 @default.
• W2957404411 cites W2733617698 @default.
• W2957404411 cites W2737006772 @default.
• W2957404411 cites W2766330061 @default.
• W2957404411 cites W2803072880 @default.
• W2957404411 cites W2803306216 @default.
• W2957404411 cites W2806819306 @default.
• W2957404411 cites W2818417770 @default.
• W2957404411 cites W2898507529 @default.
• W2957404411 cites W2903416893 @default.
• W2957404411 cites W2974178103 @default.
• W2957404411 cites W4255871125 @default.
• W2957404411 doi "https://doi.org/10.1161/jaha.119.012994" @default.
• W2957404411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6761644" @default.
• W2957404411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31310728" @default.
• W2957404411 hasPublicationYear "2019" @default.
• W2957404411 type Work @default.
• W2957404411 sameAs 2957404411 @default.
• W2957404411 citedByCount "34" @default.
• W2957404411 countsByYear W29574044112019 @default.
• W2957404411 countsByYear W29574044112020 @default.
• W2957404411 countsByYear W29574044112021 @default.
• W2957404411 countsByYear W29574044112022 @default.
• W2957404411 countsByYear W29574044112023 @default.
• W2957404411 crossrefType "journal-article" @default.
• W2957404411 hasAuthorship W2957404411A5004946791 @default.
• W2957404411 hasAuthorship W2957404411A5029602994 @default.
• W2957404411 hasAuthorship W2957404411A5031686292 @default.
• W2957404411 hasAuthorship W2957404411A5050101545 @default.
• W2957404411 hasAuthorship W2957404411A5051921393 @default.
• W2957404411 hasAuthorship W2957404411A5054061856 @default.
• W2957404411 hasAuthorship W2957404411A5070950600 @default.
• W2957404411 hasAuthorship W2957404411A5081896930 @default.
• W2957404411 hasBestOaLocation W29574044111 @default.
• W2957404411 hasConcept C104317684 @default.
• W2957404411 hasConcept C126322002 @default.
• W2957404411 hasConcept C135763542 @default.
• W2957404411 hasConcept C153852466 @default.
• W2957404411 hasConcept C156957248 @default.
• W2957404411 hasConcept C164705383 @default.
• W2957404411 hasConcept C168563851 @default.
• W2957404411 hasConcept C204243189 @default.
• W2957404411 hasConcept C22814914 @default.

• next