FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957411541> ?p ?o ?g. }

• W2957411541 endingPage "104360" @default.
• W2957411541 startingPage "104360" @default.
• W2957411541 abstract "Peritoneal carcinomatosis has an extremely poor overall prognosis and remains one of the greatest oncologic challenges. Prior studies in mice show that sodium selenite administered intraperitoneally is highly effective in inhibiting cancer cells implanted in the peritoneal cavity. However, the pharmacological mechanism remains unclear. The present study revisited the therapeutic effect of selenite and elucidated its mechanism of action. We found that intraperitoneal delivery of selenite to cancer cells in the peritoneal cavity of mice rapidly and robustly killed the cancer cells, with a therapeutic efficacy higher than that of cisplatin. The action of selenite was associated with the following pharmacological mechanisms. 1) Favorable drug distribution: selenite increased selenium levels in the cancer cells by 250-fold, while in normal tissues only by 7-fold. 2) Optimal selenium form: selenite was converted in the cancer cells mainly into selenium nanoparticles (SeNPs), which are more efficient than selenite in producing reactive oxygen species (ROS). 3) Persistent hijacking of two pro-survival systems to generate ROS: selenite did not impair thioredoxin- and glutaredoxin-coupled glutathione systems, which facilitate SeNPs to generate ROS and caused severe organelle injury and apoptotic response in the cancer cells. Overall, these mechanisms tend to maximize the potential of selenite in producing ROS in cancer cells and underlie selenite as a candidate therapeutic agent for peritoneal carcinomatosis." @default.
• W2957411541 created "2019-07-23" @default.
• W2957411541 creator A5021190456 @default.
• W2957411541 creator A5033115045 @default.
• W2957411541 creator A5033764099 @default.
• W2957411541 creator A5039598739 @default.
• W2957411541 creator A5060504169 @default.
• W2957411541 creator A5086188593 @default.
• W2957411541 date "2019-09-01" @default.
• W2957411541 modified "2023-10-17" @default.
• W2957411541 title "Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice" @default.
• W2957411541 cites W1533334334 @default.
• W2957411541 cites W1966203161 @default.
• W2957411541 cites W1968871067 @default.
• W2957411541 cites W1972181022 @default.
• W2957411541 cites W1980030522 @default.
• W2957411541 cites W1990050039 @default.
• W2957411541 cites W1992341652 @default.
• W2957411541 cites W1995194620 @default.
• W2957411541 cites W2011465631 @default.
• W2957411541 cites W2020420306 @default.
• W2957411541 cites W2020958483 @default.
• W2957411541 cites W2041312395 @default.
• W2957411541 cites W2047520295 @default.
• W2957411541 cites W2058891784 @default.
• W2957411541 cites W2059935488 @default.
• W2957411541 cites W2060148882 @default.
• W2957411541 cites W2063389371 @default.
• W2957411541 cites W2067686654 @default.
• W2957411541 cites W2068138378 @default.
• W2957411541 cites W2086793077 @default.
• W2957411541 cites W2132322608 @default.
• W2957411541 cites W2138115947 @default.
• W2957411541 cites W2138610774 @default.
• W2957411541 cites W2161500896 @default.
• W2957411541 cites W2163496089 @default.
• W2957411541 cites W2165898089 @default.
• W2957411541 cites W2197332903 @default.
• W2957411541 cites W2323882819 @default.
• W2957411541 cites W2342194767 @default.
• W2957411541 cites W2470177399 @default.
• W2957411541 cites W2510755418 @default.
• W2957411541 cites W2802809487 @default.
• W2957411541 cites W2884185085 @default.
• W2957411541 doi "https://doi.org/10.1016/j.phrs.2019.104360" @default.
• W2957411541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31326526" @default.
• W2957411541 hasPublicationYear "2019" @default.
• W2957411541 type Work @default.
• W2957411541 sameAs 2957411541 @default.
• W2957411541 citedByCount "17" @default.
• W2957411541 countsByYear W29574115412019 @default.
• W2957411541 countsByYear W29574115412020 @default.
• W2957411541 countsByYear W29574115412021 @default.
• W2957411541 countsByYear W29574115412022 @default.
• W2957411541 countsByYear W29574115412023 @default.
• W2957411541 crossrefType "journal-article" @default.
• W2957411541 hasAuthorship W2957411541A5021190456 @default.
• W2957411541 hasAuthorship W2957411541A5033115045 @default.
• W2957411541 hasAuthorship W2957411541A5033764099 @default.
• W2957411541 hasAuthorship W2957411541A5039598739 @default.
• W2957411541 hasAuthorship W2957411541A5060504169 @default.
• W2957411541 hasAuthorship W2957411541A5086188593 @default.
• W2957411541 hasConcept C121608353 @default.
• W2957411541 hasConcept C126322002 @default.
• W2957411541 hasConcept C141071460 @default.
• W2957411541 hasConcept C178790620 @default.
• W2957411541 hasConcept C185592680 @default.
• W2957411541 hasConcept C190283241 @default.
• W2957411541 hasConcept C202751555 @default.
• W2957411541 hasConcept C2776120743 @default.
• W2957411541 hasConcept C2778536324 @default.
• W2957411541 hasConcept C2780427987 @default.
• W2957411541 hasConcept C48349386 @default.
• W2957411541 hasConcept C502942594 @default.
• W2957411541 hasConcept C553756173 @default.
• W2957411541 hasConcept C55493867 @default.
• W2957411541 hasConcept C71924100 @default.
• W2957411541 hasConcept C96232424 @default.
• W2957411541 hasConcept C98274493 @default.
• W2957411541 hasConceptScore W2957411541C121608353 @default.
• W2957411541 hasConceptScore W2957411541C126322002 @default.
• W2957411541 hasConceptScore W2957411541C141071460 @default.
• W2957411541 hasConceptScore W2957411541C178790620 @default.
• W2957411541 hasConceptScore W2957411541C185592680 @default.
• W2957411541 hasConceptScore W2957411541C190283241 @default.
• W2957411541 hasConceptScore W2957411541C202751555 @default.
• W2957411541 hasConceptScore W2957411541C2776120743 @default.
• W2957411541 hasConceptScore W2957411541C2778536324 @default.
• W2957411541 hasConceptScore W2957411541C2780427987 @default.
• W2957411541 hasConceptScore W2957411541C48349386 @default.
• W2957411541 hasConceptScore W2957411541C502942594 @default.
• W2957411541 hasConceptScore W2957411541C553756173 @default.
• W2957411541 hasConceptScore W2957411541C55493867 @default.
• W2957411541 hasConceptScore W2957411541C71924100 @default.
• W2957411541 hasConceptScore W2957411541C96232424 @default.
• W2957411541 hasConceptScore W2957411541C98274493 @default.
• W2957411541 hasFunder F4320321001 @default.
• W2957411541 hasLocation W29574115411 @default.

• next