FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2957520025> ?p ?o ?g. }

• W2957520025 abstract "Abstract Background Identifying effective candidate drug compounds in patients with neurological disorders based on gene expression data is of great importance to the neurology field. By identifying effective candidate drugs to a given neurological disorder, neurologists would (1) reduce the time searching for effective treatments; and (2) gain additional useful information that leads to a better treatment outcome. Although there are many strategies to screen drug candidate in pre-clinical stage, it is not easy to check if candidate drug compounds can be also effective to human. Objective We tried to propose a strategy to screen genes whose expression is altered in model animal experiments to be compared with gene expressed differentically with drug treatment to human cell lines. Methods Recently proposed tensor decomposition (TD) based unsupervised feature extraction (FE) is applied to single cell (sc) RNA-seq experiments of Alzheimer’s disease model animal mouse brain. Results Four hundreds and one genes are screened as those differentially expressed during A β accumulation as age progresses. These genes are significantly overlapped with those expressed differentially with the known drug treatments for three independent data sets: LINCS, DrugMatrix and GEO. Conclusion Our strategy, application of TD based unsupervised FE, is useful one to screen drug candidate compounds using scRNA-seq data set." @default.
• W2957520025 created "2019-07-23" @default.
• W2957520025 creator A5007548463 @default.
• W2957520025 creator A5045603108 @default.
• W2957520025 date "2019-07-16" @default.
• W2957520025 modified "2023-09-27" @default.
• W2957520025 title "Neurological disorder drug discovery from gene expression with tensor decomposition" @default.
• W2957520025 cites W1486176185 @default.
• W2957520025 cites W1877411992 @default.
• W2957520025 cites W1966845080 @default.
• W2957520025 cites W1985226998 @default.
• W2957520025 cites W1998173868 @default.
• W2957520025 cites W2013725205 @default.
• W2957520025 cites W2024165284 @default.
• W2957520025 cites W2024969564 @default.
• W2957520025 cites W2043435036 @default.
• W2957520025 cites W2097124604 @default.
• W2957520025 cites W2118482957 @default.
• W2957520025 cites W2143214705 @default.
• W2957520025 cites W2158215064 @default.
• W2957520025 cites W2267663640 @default.
• W2957520025 cites W2299350316 @default.
• W2957520025 cites W2345356016 @default.
• W2957520025 cites W2482092413 @default.
• W2957520025 cites W2582450548 @default.
• W2957520025 cites W2586834816 @default.
• W2957520025 cites W2634812549 @default.
• W2957520025 cites W2651764022 @default.
• W2957520025 cites W2738849193 @default.
• W2957520025 cites W2748836724 @default.
• W2957520025 cites W2763782267 @default.
• W2957520025 cites W2766118696 @default.
• W2957520025 cites W2766932388 @default.
• W2957520025 cites W2783410689 @default.
• W2957520025 cites W2805643180 @default.
• W2957520025 cites W2882992973 @default.
• W2957520025 cites W2900706096 @default.
• W2957520025 cites W2913422047 @default.
• W2957520025 cites W2941510527 @default.
• W2957520025 cites W2947369257 @default.
• W2957520025 cites W2950130101 @default.
• W2957520025 cites W2963881378 @default.
• W2957520025 cites W2963958000 @default.
• W2957520025 cites W2965805843 @default.
• W2957520025 cites W4231923902 @default.
• W2957520025 cites W4241513149 @default.
• W2957520025 doi "https://doi.org/10.1101/704163" @default.
• W2957520025 hasPublicationYear "2019" @default.
• W2957520025 type Work @default.
• W2957520025 sameAs 2957520025 @default.
• W2957520025 citedByCount "0" @default.
• W2957520025 crossrefType "posted-content" @default.
• W2957520025 hasAuthorship W2957520025A5007548463 @default.
• W2957520025 hasAuthorship W2957520025A5045603108 @default.
• W2957520025 hasBestOaLocation W29575200251 @default.
• W2957520025 hasConcept C104317684 @default.
• W2957520025 hasConcept C142724271 @default.
• W2957520025 hasConcept C150194340 @default.
• W2957520025 hasConcept C16568411 @default.
• W2957520025 hasConcept C169760540 @default.
• W2957520025 hasConcept C2779134260 @default.
• W2957520025 hasConcept C2780035454 @default.
• W2957520025 hasConcept C3019038264 @default.
• W2957520025 hasConcept C54355233 @default.
• W2957520025 hasConcept C60644358 @default.
• W2957520025 hasConcept C69991583 @default.
• W2957520025 hasConcept C70721500 @default.
• W2957520025 hasConcept C71924100 @default.
• W2957520025 hasConcept C74187038 @default.
• W2957520025 hasConcept C86803240 @default.
• W2957520025 hasConcept C98274493 @default.
• W2957520025 hasConceptScore W2957520025C104317684 @default.
• W2957520025 hasConceptScore W2957520025C142724271 @default.
• W2957520025 hasConceptScore W2957520025C150194340 @default.
• W2957520025 hasConceptScore W2957520025C16568411 @default.
• W2957520025 hasConceptScore W2957520025C169760540 @default.
• W2957520025 hasConceptScore W2957520025C2779134260 @default.
• W2957520025 hasConceptScore W2957520025C2780035454 @default.
• W2957520025 hasConceptScore W2957520025C3019038264 @default.
• W2957520025 hasConceptScore W2957520025C54355233 @default.
• W2957520025 hasConceptScore W2957520025C60644358 @default.
• W2957520025 hasConceptScore W2957520025C69991583 @default.
• W2957520025 hasConceptScore W2957520025C70721500 @default.
• W2957520025 hasConceptScore W2957520025C71924100 @default.
• W2957520025 hasConceptScore W2957520025C74187038 @default.
• W2957520025 hasConceptScore W2957520025C86803240 @default.
• W2957520025 hasConceptScore W2957520025C98274493 @default.
• W2957520025 hasLocation W29575200251 @default.
• W2957520025 hasOpenAccess W2957520025 @default.
• W2957520025 hasPrimaryLocation W29575200251 @default.
• W2957520025 hasRelatedWork W1990688647 @default.
• W2957520025 hasRelatedWork W2009966535 @default.
• W2957520025 hasRelatedWork W2094082417 @default.
• W2957520025 hasRelatedWork W2111172999 @default.
• W2957520025 hasRelatedWork W2180772869 @default.
• W2957520025 hasRelatedWork W2278639344 @default.
• W2957520025 hasRelatedWork W2386328366 @default.
• W2957520025 hasRelatedWork W2772481372 @default.
• W2957520025 hasRelatedWork W2934840264 @default.
• W2957520025 hasRelatedWork W3118459188 @default.

• next